| Singles | |
|---|---|
| 2018 AON Open Challenger | |
| Champion |  Lorenzo Sonego |
| Runner-up |  Dustin Brown |
| Final score | 6–2, 6–1 |
Stefanos Tsitsipas was the defending champion but chose not to defend his title.
Lorenzo Sonego won the title after defeating Dustin Brown 6–2, 6–1 in the final.
Benoît Paire (withdrew)
Martin Kližan (second round, retired) Paolo Lorenzi (second round)
Hubert Hurkacz (quarterfinals)
Federico Delbonis (semifinals) Guido Andreozzi (first round)
Thiago Monteiro (first round) Lorenzo Sonego (champion)| Semifinals | Final | ||||||||||||
| 5 | Federico Delbonis | 5 | 3 | ||||||||||
| 8 | Lorenzo Sonego | 7 | 6 | ||||||||||
| 8 | Lorenzo Sonego | 6 | 6 | ||||||||||
| WC | Dustin Brown | 2 | 1 | ||||||||||
| WC | Dustin Brown | 6 | 78 | ||||||||||
| LL | Thomaz Bellucci | 3 | 66 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| LL |  JP Varillas | 6 | 5 | 3 | |||||||||||||||||||||||
| S Travaglia | 4 | 7 | 6 | S Travaglia | 6 | 6 | |||||||||||||||||||||
| G Quinzi | 6 | 4 | 3 |  V Galović | 4 | 4 | |||||||||||||||||||||
| V Galović | 4 | 6 | 6 | S Travaglia | 3 | 6 | 61 | ||||||||||||||||||||
| WC | G Fonio | 6 | 6 | 5 | F Delbonis | 6 | 3 | 77 | |||||||||||||||||||
 G Elias | 4 | 2 | WC | G Fonio | 1 | 3 | |||||||||||||||||||||
| R Dutra Silva | 6 | 4 | 3 | 5 | F Delbonis | 6 | 6 | ||||||||||||||||||||
| 5 | F Delbonis | 4 | 6 | 6 | 5 | F Delbonis | 5 | 3 | |||||||||||||||||||
| 4 | H Hurkacz | 6 | 1 | 6 | 8 | L Sonego | 7 | 6 | |||||||||||||||||||
| A Arnaboldi | 3 | 6 | 2 | 4 | H Hurkacz | 5 | 7 | 6 | |||||||||||||||||||
| Q |  Z Piros | 4 | 1r | JI Londero | 7 | 5 | 0 | ||||||||||||||||||||
| JI Londero | 6 | 4 | 4 | H Hurkacz | 6 | 3 | 61 | ||||||||||||||||||||
| Q |  A Avidzba | 6 | 4 | 1 | 8 | L Sonego | 1 | 6 | 77 | ||||||||||||||||||
| A Vatutin | 1 | 6 | 6 | A Vatutin | 4 | 6 | 5 | ||||||||||||||||||||
| S Robert | 1 | 2 | 8 | L Sonego | 6 | 4 | 7 | ||||||||||||||||||||
| 8 | L Sonego | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | G Andreozzi | 5 | 6 | 0 | |||||||||||||||||||||||
| WC | A Basso | 7 | 4 | 6 | WC | A Basso | 2 | 7 | 2 | ||||||||||||||||||
| WC | D Brown | 6 | 7 | WC | D Brown | 6 | 5 | 6 | |||||||||||||||||||
 P Andújar | 4 | 5 | WC | D Brown | 3 | 6 | 77 | ||||||||||||||||||||
| Q | A Pellegrino | 2 | 4 | Alt |  L Rosol | 6 | 4 | 65 | |||||||||||||||||||
| Alt | L Rosol | 6 | 6 | Alt | L Rosol | 77 | 6 | ||||||||||||||||||||
| S Caruso | 2 | 6 | 4 | 3 | P Lorenzi | 64 | 3 | ||||||||||||||||||||
| 3 | P Lorenzi | 6 | 3 | 6 | WC | D Brown | 6 | 78 | |||||||||||||||||||
| 7 | T Monteiro | 3 | 4 | LL | T Bellucci | 3 | 66 | ||||||||||||||||||||
 C Garín | 6 | 6 | C Garín | 3 | 6 | 6 | |||||||||||||||||||||
| S Napolitano | 4 | 2 | Q |  S Nagal | 6 | 3 | 4 | ||||||||||||||||||||
| Q | S Nagal | 6 | 6 | C Garín | 65 | 4 | |||||||||||||||||||||
| LL | T Bellucci | 78 | 6 | LL | T Bellucci | 77 | 6 | ||||||||||||||||||||
| GM Moroni | 66 | 3 | LL | T Bellucci | 3 | 7 | 4 | ||||||||||||||||||||
| WC | F Baldi | 0 | 2 | 2 | M Kližan | 6 | 5 | 0r | |||||||||||||||||||
| 2 | M Kližan | 6 | 6 | ||||||||||||||||||||||||
Jerzy Janowicz was the defending champion but chose not to defend his title.
Aljaž Bedene was the defending champion but chose not to defend his title.
Márton Fucsovics was the defending champion but chose not to defend his title.
Leonardo Mayer was the defending champion, but lost in the final to Nikoloz Basilashvili, 4–6, 6–0, 5–7. This was Basilashvili's first ATP World Tour title, as well as the first ATP title won by a Georgian player since Alexander Metreveli.
Richard Gasquet was the defending champion but chose not to defend his title.
Lorenzo Sonego was the defending champion but lost in the first round to Constant Lestienne.
Yannick Hanfmann was the defending champion but chose not to defend his title.
Dominic Thiem was the defending champion, but lost to Diego Schwartzman in the semifinals.
Pablo Andújar was the defending champion, but lost in the final to Benoît Paire, 2–6, 3–6.
Alexander Zverev was the two-time defending champion, but lost to Cristian Garín in the quarterfinals.
Márton Fucsovics was the defending champion, but lost in the second round to Federico Delbonis.
Damir Džumhur was the defending champion, but retired from his quarterfinal match against Jordan Thompson.
Matteo Berrettini was the defending champion, but withdrew with an ankle injury before the tournament began.
Lorenzo Sonego was the defending champion and successfully defended his title, defeating Alejandro Davidovich Fokina 6–2, 4–6, 7–6(8–6) in the final.
Dominic Thiem was the defending champion, but lost to Andrey Rublev in the quarterfinals.
Lorenzo Sonego was the defending champion but chose not to participate. Alex de Minaur won the title, having defeated in the final Alexander Bublik with the score 2-0 ret.
Gaël Monfils was the defending champion, but chose not to defend his title.
Lorenzo Sonego defeated defending champion Laslo Đere in the final, 2–6, 7–6(7–5), 6–4 to win the men's singles title at the 2021 Sardegna Open. With the victory, Sonego became the first Italian in 15 years to capture an ATP Tour title on home soil.
Taylor Fritz was the defending champion from when the event was last held in 2019, but withdrew before the tournament with a knee injury.
Casper Ruud defeated the defending champion Diego Schwartzman in the final, 5–7, 6–2, 6–3 to win the singles title at the 2022 Argentina Open.