| Doubles | |
|---|---|
| 2018 Empire Slovak Open | |
| Champions |  Jessica Moore  Galina Voskoboeva |
| Runners-up |  Xenia Knoll  Anna Smith |
| Score | 0–6, 6–3, [10–7] |
Naomi Broady and Heather Watson were the defending champions, however Watson chose not to participate, while Broady chose to compete at the 2018 Kurume U.S.E Cup.
Jessica Moore and Galina Voskoboeva won the title after defeating Xenia Knoll and Anna Smith 0–6, 6–3, [10–7] in the final.
Xenia Knoll / Anna Smith (final) Viktorija Golubic / 
Yanina Wickmayer (withdrew)
Darija Jurak / 
Cornelia Lister (first round)
Kaitlyn Christian / Sabrina Santamaria (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | X Knoll A Smith | 3 | 77 | [11] | |||||||||||||||||||||||
I Falconi  M Hončová | 6 | 65 | [9] | 1 | X Knoll A Smith | 5 | 78 | [10] | |||||||||||||||||||
 N Dascălu C Dinu | 0 | 5 |  D Gálfi  A Potapova | 7 | 66 | [5] | |||||||||||||||||||||
| D Gálfi A Potapova | 6 | 7 | 1 | X Knoll A Smith | 6 | 4 | [11] | ||||||||||||||||||||
| 4 | K Christian S Santamaria | 712 | 6 |  O Kalashnikova  D Kovinić | 3 | 6 | [9] | ||||||||||||||||||||
| Á Bukta V Juhászová | 610 | 1 | 4 | K Christian S Santamaria | 4 | 1 | |||||||||||||||||||||
| O Kalashnikova D Kovinić | 6 | 6 | O Kalashnikova D Kovinić | 6 | 6 | ||||||||||||||||||||||
| WC | L Maluniaková E Siska | 4 | 0 | 1 | X Knoll A Smith | 6 | 3 | [7] | |||||||||||||||||||
M Brengle  P Thombare | 1 | 1 | J Moore G Voskoboeva | 0 | 6 | [10] | |||||||||||||||||||||
| J Moore G Voskoboeva | 6 | 6 | J Moore G Voskoboeva | 4 | 6 | [10] | |||||||||||||||||||||
| WC | V Kužmová T Mihalíková | 7 | 3 | [16] | WC | V Kužmová T Mihalíková | 6 | 4 | [3] | ||||||||||||||||||
| 3 | D Jurak C Lister | 5 | 6 | [14] | J Moore G Voskoboeva | 6 | 6 | ||||||||||||||||||||
| A Fomina E Yashina | 6 | 6 | A Fomina E Yashina | 1 | 4 | ||||||||||||||||||||||
| WC | K Bekker  E Vogelsang | 2 | 3 | A Fomina E Yashina | 6 | 6 | |||||||||||||||||||||
 A Khabibulina  A Vasylyeva | w/o | A Khabibulina A Vasylyeva | 3 | 2 | |||||||||||||||||||||||
| 2 | V Golubic Y Wickmayer | ||||||||||||||||||||||||||
Tímea Babos and Kristina Mladenovic were the defending champions, but chose not to participate this year.
Xenia Knoll and Aleksandra Krunić won the title, defeating Tatjana Maria and Raluca Olaru in the final, 6–3, 6–0.
Johanna Konta and Laura Thorpe were the defending champions, but Thorpe chose not to participate, whilst Konta chose to participate in Madrid instead.
Asia Muhammad and Laura Siegemund were the defending champions, but Siegemund chose not to participate this year. Muhammad played alongside María José Martínez Sánchez, but lost in the quarterfinals to Alexandra Panova and Amra Sadiković.
Oksana Kalashnikova and Yaroslava Shvedova won the title, defeating Xenia Knoll and Aleksandra Krunić in the final, 6–1, 6–1.
Mona Barthel and Laura Siegemund were the defending champions, but Barthel chose not to participate this year. Siegemund played alongside Antonia Lottner, but lost in the first round to Annika Beck and Xenia Knoll.
Martina Hingis and Sania Mirza were the defending champions, but Mirza chose not to participate this year. Hingis played alongside Belinda Bencic, but lost in the first round to Gabriela Dabrowski and Michaëlla Krajicek.
Anna Kalinskaya and Tereza Mihalíková were the defending champions, but Kalinskaya chose to participate in Saint-Gaudens instead. Mihalíková partnered with Chantal Škamlová, but they lost in the first round to Chuang Chia-jung and Renata Voráčová.
Sanaz Marand and Melanie Oudin were the defending champions, but both players chose not to participate.
Oksana Kalashnikova and Yaroslava Shvedova were the defending champions, but chose not to participate this year.
Lara Arruabarrena and Xenia Knoll were the defending champions, but Arruabarrena chose not to participate this year. Knoll played alongside Anastasiya Komardina, but lost in the quarterfinals to Anna Kalinskaya and Evgeniya Rodina.
Andrea Hlaváčková and Lucie Hradecká were the defending champions, but decided not to compete together. Hradecká partnered with Barbora Krejčíková, but lost in the quarterfinals to Bianca Andreescu and Carson Branstine. Hlaváčková partnered with Tímea Babos and successfully defended her title, defeating Andreescu and Branstine 6–3, 6–1 in the final.
Hsieh Su-wei and Monica Niculescu were the defending champions, but chose not to participate this year.
Dalila Jakupović and Nadiia Kichenok were the defending champions, but Kichenok chose to compete in Stuttgart instead. Jakupović played alongside Irina Khromacheva, but lost in the first round to Natela Dzalamidze and Anna Kalinskaya.
Tímea Babos and Andrea Sestini Hlaváčková were the defending champions, but Babos chose not to participate and Sestini Hlaváčková chose to compete in Prague instead.
Dominika Cibulková and Kirsten Flipkens were the defending champions, but Cibulková chose not to participate this year. Flipkens played alongside Kiki Bertens, but lost in the final to Elise Mertens and Demi Schuurs when Flipkens had to retire with the score at 3–3.
Kiki Bertens and Johanna Larsson were the defending champions, but Bertens chose not to participate. Larsson played alongside Kirsten Flipkens and successfully defended the title, defeating Raquel Atawo and Anna-Lena Grönefeld in the final, 4–6, 6–4, [10–5].
Kaitlyn Christian and Sabrina Santamaria were the defending champions, but both players chose not to participate.
Jessica Moore and Galina Voskoboeva were the defending champions, but both players chose not to participate.
Kirsten Flipkens and Johanna Larsson were the defending champions. Larsson chose not to participate and Flipkens was scheduled to play alongside Alison Van Uytvanck, but withdrew due to a wrist injury.
Anna Danilina and Ekaterine Gorgodze were the defending champions but chose not to participate.
The women's doubles of the 2021 I.ČLTK Prague Open tournament was played on clay in Prague, Czech Republic.