| Men's singles | |
|---|---|
| 2018 Fergana Challenger | |
| Champion |  Nikola Milojević |
| Runner-up |  Enrique López Pérez |
| Final score | 6–3, 6–4 |
Ilya Ivashka was the defending champion but chose not to defend his title.
Nikola Milojević won the title after defeating Enrique López Pérez 6–3, 6–4 in the final.
Nikola Milojević (champion) Enrique López Pérez (final)
Gonçalo Oliveira (second round)
Lee Duck-hee (second round)
Ivan Nedelko (second round, withdrew)
Egor Gerasimov (semifinals)
Roberto Cid Subervi (second round)
Yosuke Watanuki (quarterfinals)| Semifinals | Final | ||||||||||||
| 1 | Nikola Milojević | 6 | 5 | 6 | |||||||||
| Q |  Saketh Myneni | 4 | 7 | 0 | |||||||||
| 1 | Nikola Milojević | 6 | 6 | ||||||||||
| 2 | Enrique López Pérez | 3 | 4 | ||||||||||
| 6 | Egor Gerasimov | 4 | 4 | ||||||||||
| 2 | Enrique López Pérez | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | N Milojević | 7 | 610 | 6 | |||||||||||||||||||||||
| Q | K Kravchuk | 5 | 712 | 4 | 1 | N Milojević | 6 | 7 | |||||||||||||||||||
| E Karlovskiy | 6 | 6 | E Karlovskiy | 3 | 5 | ||||||||||||||||||||||
 J Menezes | 2 | 2 | 1 | N Milojević | 6 | 69 | 6 | ||||||||||||||||||||
| Q |  T-l Wu | 7 | 77 | 8 | Yo Watanuki | 1 | 711 | 3 | |||||||||||||||||||
| I Gakhov | 5 | 61 | Q | T-l Wu | 77 | 2 | 3 | ||||||||||||||||||||
 A Nedovyesov | 4 | 64 | 8 | Yo Watanuki | 65 | 6 | 6 | ||||||||||||||||||||
| 8 | Yo Watanuki | 6 | 77 | 1 | N Milojević | 6 | 5 | 6 | |||||||||||||||||||
| 3 | G Oliveira | 5 | 6 | 6 | Q | S Myneni | 4 | 7 | 0 | ||||||||||||||||||
| T Gabashvili | 7 | 3 | 3 | 3 | G Oliveira | 3 | 77 | 4 | |||||||||||||||||||
 C İlkel | 6 | 6 | C İlkel | 6 | 65 | 6 | |||||||||||||||||||||
 A Bega | 2 | 2 | C İlkel | 1 | 77 | 4 | |||||||||||||||||||||
| D Zhyrmont | 4 | 0 | Q | S Myneni | 6 | 65 | 6 | ||||||||||||||||||||
| Q | S Myneni | 6 | 6 | Q | S Myneni | 6 | 6 | ||||||||||||||||||||
 M Eriksson | 4 | 3 | 7 | R Cid Subervi | 0 | 4 | |||||||||||||||||||||
| 7 | R Cid Subervi | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | E Gerasimov | 6 | 6 | ||||||||||||||||||||||||
 L Grigelis | 2 | 3 | 6 | E Gerasimov | 6 | 77 | |||||||||||||||||||||
| WC |  F Dustov | 6 | 4 | 6 | WC | F Dustov | 3 | 64 | |||||||||||||||||||
 Y Mertens | 4 | 6 | 3 | 6 | E Gerasimov | 6 | 77 | ||||||||||||||||||||
| WC | D Yevseyev | 3 | 3 |  A Šetkić | 3 | 64 | |||||||||||||||||||||
| A Šetkić | 6 | 6 | A Šetkić | 6 | 6 | ||||||||||||||||||||||
| Y Takahashi | 63 | 1 | 4 | D-h Lee | 2 | 3 | |||||||||||||||||||||
| 4 | D-h Lee | 77 | 6 | 6 | E Gerasimov | 4 | 4 | ||||||||||||||||||||
| 5 | I Nedelko | 5 | 6 | 77 | 2 | E López Pérez | 6 | 6 | |||||||||||||||||||
| WC | S Fayziev | 7 | 3 | 60 | 5 | I Nedelko | |||||||||||||||||||||
 R Statham | 6 | 65 | 2 | Q | S Sekiguchi | w/o | |||||||||||||||||||||
| Q | Shuichi Sekiguchi | 1 | 77 | 6 | Q | S Sekiguchi | 2 | 0r | |||||||||||||||||||
| R Ortega Olmedo | 66 | 3 | 2 | E López Pérez | 6 | 4 | |||||||||||||||||||||
| WC | K Sultanov | 78 | 6 | WC | K Sultanov | 5 | 63 | ||||||||||||||||||||
 D Guez | 0 | 6 | 2 | 2 | E López Pérez | 7 | 77 | ||||||||||||||||||||
| 2 | E López Pérez | 6 | 2 | 6 | |||||||||||||||||||||||
Tiago Fernandes was the defending champion, having defeated Sean Berman in the 2010 final. He chose not to defend his title.
Jiří Veselý won the title defeating Luke Saville 6–0, 6–3, in the final. The player from Czech Republic won every match in straight sets.
Filip Horanský and Jiří Veselý were the defending champions but were both ineligible to compete.
Teymuraz Gabashvili was the defending champion, but chose not to defend his title.
Dominic Thiem was the defending champion, but chose to compete in Kitzbühel instead.
Radu Albot was the defending champion but chose not to defend his title.
Adam Pavlásek was the defending champion but chose not to defend his title.
Janko Tipsarević was the defending champion but chose not to defend his title.
Timur Khabibulin and Aleksandr Nedovyesov were the defending champions but lost in the quarterfinals to Nikola Čačić and Nino Serdarušić.
Laslo Đere was the defending champion but chose not to defend his title.
Jurij Rodionov was the defending champion but chose not to defend his title.
Pablo Andújar was the defending champion and successfully defended his title.
Marco Trungelliti was the defending champion but chose not to defend his title.
Prajnesh Gunneswaran was the defending champion but lost in the final to Jay Clarke.
Quentin Halys was the defending champion but chose not to defend his title.
Andrej Martin was the defending champion but lost in the second round to Alex Molčan.
Karen Khachanov was the defending champion, but lost in the quarterfinals to Andreas Seppi.
Pablo Carreño Busta defeated Jaume Munar in the final, 6–1, 2–6, 6–4 to win the inaugural Men's Singles tennis title at the 2021 Andalucía Open. Notably, this was the first tournament in ATP history to feature 4 semifinalists from the same nation.
Tallon Griekspoor was the defending champion but chose not to defend his title.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Nikola Milojević was the defending champion but lost in the first round to Eduard Esteve Lobato.