| Singles | |
|---|---|
| 2019 Brasil Open | |
| Champion |  Guido Pella |
| Runner-up |  Cristian Garín |
| Final score | 7–5, 6–3 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
 |
Fabio Fognini was the defending champion, [1] but chose not to defend his title.
Guido Pella won his first ATP title, defeating Cristian Garín 7–5, 6–3 in the final.
The top four seeds received a bye into the second round.
João Sousa (second round)
Malek Jaziri (second round) Guido Pella (champion) Leonardo Mayer (quarterfinals)
Pablo Cuevas (first round)
Jaume Munar (second round) Juan Ignacio Londero (second round)
Taro Daniel (first round)| Semifinals | Final | ||||||||||||
 Casper Ruud | 4 | 4 | |||||||||||
| Cristian Garín | 6 | 6 | |||||||||||
| Cristian Garín | 5 | 3 | |||||||||||
| 3 | Guido Pella | 7 | 6 | ||||||||||
| 3 | Guido Pella | 712 | 77 | ||||||||||
 Laslo Đere | 610 | 61 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | J Sousa | 3 | 4 | ||||||||||||||||||||||||
| C Ruud | 6 | 6 | C Ruud | 6 | 6 | ||||||||||||||||||||||
| WC |  T Monteiro | 3 | 4 | C Ruud | 6 | 6 | |||||||||||||||||||||
| Q | P Martínez | 1 | 2 |  H Dellien | 1 | 1 | |||||||||||||||||||||
| H Dellien | 6 | 6 | H Dellien | 6 | 77 | ||||||||||||||||||||||
 P Lorenzi | 63 | 1 | 7 | JI Londero | 4 | 63 | |||||||||||||||||||||
| 7 | JI Londero | 77 | 6 | C Ruud | 4 | 4 | |||||||||||||||||||||
| C Garín | 6 | 6 | |||||||||||||||||||||||||
| 4 | L Mayer | 6 | 3 | 6 | |||||||||||||||||||||||
| L Sonego | 6 | 6 | L Sonego | 1 | 6 | 3 | |||||||||||||||||||||
| F Delbonis | 4 | 4 | 4 | L Mayer | 6 | 4 | 4 | ||||||||||||||||||||
| P Sousa | 63 | 2 | C Garín | 4 | 6 | 6 | |||||||||||||||||||||
| C Garín | 77 | 6 | C Garín | 77 | 64 | 77 | |||||||||||||||||||||
| Q | P Sakamoto | 3 | 2 | 6 | J Munar | 65 | 77 | 62 | |||||||||||||||||||
| 6 | J Munar | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | T Daniel | 4 | 6 | 65 | |||||||||||||||||||||||
| M Trungelliti | 6 | 3 | 77 | M Trungelliti | 6 | 7 | |||||||||||||||||||||
| WC | T Seyboth Wild | 6 | 4 | 6 | WC | T Seyboth Wild | 4 | 5 | |||||||||||||||||||
 E Ymer | 3 | 6 | 2 | M Trungelliti | 0 | 3 | |||||||||||||||||||||
| R Carballés Baena | 3 | 6 | 6 | 3 | G Pella | 6 | 6 | ||||||||||||||||||||
 M Marterer | 6 | 1 | 2 | R Carballés Baena | 2 | 4 | |||||||||||||||||||||
| 3 | G Pella | 6 | 6 | ||||||||||||||||||||||||
| 3 | G Pella | 712 | 77 | ||||||||||||||||||||||||
| 5/WC | P Cuevas | 7 | 3 | 3 | L Đere | 610 | 61 | ||||||||||||||||||||
 F Auger-Aliassime | 5 | 6 | 6 | F Auger-Aliassime | 77 | 77 | |||||||||||||||||||||
| Q | F Bagnis | 1 | 3 | A Ramos Viñolas | 62 | 65 | |||||||||||||||||||||
| A Ramos Viñolas | 6 | 6 | F Auger-Aliassime | 2 | 6 | 3 | |||||||||||||||||||||
| Q | A Giannessi | 65 | 6 | 4 | L Đere | 6 | 3 | 6 | |||||||||||||||||||
| L Đere | 77 | 4 | 6 | L Đere | 6 | 3 | 77 | ||||||||||||||||||||
| 2 | M Jaziri | 3 | 6 | 62 | |||||||||||||||||||||||
Carlos Berlocq (qualifying competition) Facundo Bagnis (qualified) Alessandro Giannessi (qualified) Pedro Martínez (qualified) Daniel Gimeno Traver (first round) Facundo Argüello (first round)
Kimmer Coppejans (qualifying competition) Matteo Donati (first round)| First round | Qualifying competition | ||||||||||||
| 1 | Carlos Berlocq | 1 | 6 | 6 | |||||||||
| Gian Marco Moroni | 6 | 3 | 4 | ||||||||||
| 1 | Carlos Berlocq | 64 | 4 | ||||||||||
| Pedro Sakamoto | 77 | 6 | |||||||||||
| Pedro Sakamoto | 6 | 6 | |||||||||||
| 8 | Matteo Donati | 1 | 4 | ||||||||||
| First round | Qualifying competition | ||||||||||||
| 2 | Facundo Bagnis | 6 | 6 | ||||||||||
 Alen Avidzba | 1 | 4 | |||||||||||
| 2 | Facundo Bagnis | 77 | 6 | ||||||||||
 Andrej Martin | 64 | 2 | |||||||||||
| Andrej Martin | 6 | 6 | |||||||||||
| 5 | Daniel Gimeno Traver | 3 | 1 | ||||||||||
| First round | Qualifying competition | ||||||||||||
| 3 | Alessandro Giannessi | 77 | 6 | ||||||||||
| WC | João Souza | 65 | 3 | ||||||||||
| 3 | Alessandro Giannessi | 6 | 6 | ||||||||||
| 7 | Kimmer Coppejans | 4 | 2 | ||||||||||
| João Domingues | 6 | 0 | 3 | ||||||||||
| 7 | Kimmer Coppejans | 4 | 6 | 6 | |||||||||
| First round | Qualifying competition | ||||||||||||
| 4 | Pedro Martínez | 77 | 6 | ||||||||||
| WC | João Menezes | 64 | 1 | ||||||||||
| 4 | Pedro Martínez | 6 | 6 | ||||||||||
| Federico Coria | 1 | 1 | |||||||||||
| Federico Coria | 6 | 6 | |||||||||||
| 6 | Facundo Argüello | 1 | 4 | ||||||||||
David Ferrer is the defending champion. He successfully defended his title by defeating 8th seed Fernando Verdasco, 6–1, 6–2 in the final.
Horacio Zeballos was the defending champion, but lost in the second round to Daniel Gimeno Traver.
Fabio Fognini won the title, defeating Leonardo Mayer in the final 6–2, 6–4.
Federico Delbonis was the defending champion, but lost to Facundo Bagnis in the first round.
Pablo Cuevas won the title, defeating Luca Vanni in the final, 6–4, 3–6, 7–6(7–4).
Rafael Nadal was the defending champion, but lost in the semifinals to Fabio Fognini.
David Ferrer was the three-time defending champion, but he chose to compete in Acapulco instead.
Rafael Nadal won the title, defeating Juan Mónaco in the final, 6–4, 6–1.
David Ferrer was the defending champion, but lost in the quarterfinals to Dominic Thiem.
Dominic Thiem was the defending champion, but chose to compete in Rotterdam instead.
Pablo Cuevas was the two-time defending champion and successfully defended his title, defeating Albert Ramos Viñolas in the final, 6–7(3–7), 6–4, 6–4.
Paolo Lorenzi was the defending champion, but lost in the second round to João Sousa.
Víctor Estrella Burgos was the three-time defending champion and the tournament's only champion to date, but lost in the second round to Gerald Melzer.
Alexandr Dolgopolov was the defending champion, but withdrew before the tournament began.
This was the first edition of the tournament.
Marco Cecchinato was the defending champion but chose not to defend his title.
Tommy Robredo was the defending champion but retired in the first round against Maxime Janvier.
Cristian Garín was the defending champion but chose not to defend his title.
Juan Ignacio Londero was the defending champion, but lost to Laslo Đere in the quarterfinals.
Marco Cecchinato was the defending champion, but lost in the first round to Roberto Carballés Baena.
Laslo Đere was the defending champion, but withdrew with an abdominal injury before the tournament began.
Cristian Garín was the defending champion, but chose not to defend his title.
Pedro Martínez defeated Sebastián Báez in the final, 4–6, 6–4, 6–4 to win the singles title at the 2022 Chile Open. It was his first ATP Tour title.