Michaëlla Krajicek and Maria Sanchez were the defending champions, but Krajicek chose not to participate. Sanchez chose to partner Jovana Jakšić, but they lost in the first round to Sabrina Santamaria and Carol Zhao.
Catherine Bellis was the defending champion, but decided not to participate this year.
Elena Bogdan and Mihaela Buzărnescu were the defending champions, but decided not to participate this year.
Gabriela Dabrowski and Michaëlla Krajicek were the defending champions, but decided not to participate this year.
Xenia Knoll and Amra Sadiković were the defending champions, but both players chose not to participate.
Asia Muhammad and Maria Sanchez were the defending champions, but chose not to participate.
Sophie Chang and Alexandra Mueller were the defending champions, but lost in the semifinals to Vladica Babić and Caitlin Whoriskey.
Katherine Sebov was the defending champion, but chose not to participate.
This was the first edition of the tournament.
This was the first edition of the tournament.
Samantha Stosur and Zhang Shuai defeated Coco Gauff and Caty McNally in the final, 6–3, 3–6, 6–3 to win the women's doubles title at the 2021 US Open. It was Stosur's fourth major title in women's doubles and eighth major overall, as well as Zhang's second major title; this was the team's second major title, following the 2019 Australian Open. This was the first major final for Gauff and for McNally.
Mayo Hibi was the defending champion but chose to compete at the 2021 BNP Paribas Open instead.
Olga Govortsova and Mandy Minella were the defending champions but chose not to participate.
Akgul Amanmuradova and Ekaterine Gorgodze were the defending champions but chose not to participate.
Cara Black and Arina Rodionova were the defending champions, having won the previous edition in 2012. However Black retired from professional tennis in 2015 and Rodionova chose to compete at the 2022 Melbourne Summer Set instead.
Emina Bektas and Tara Moore were the defending champions but chose not to participate.
Emina Bektas and Tara Moore were the defending champions but were defeated by Sophie Chang and Angela Kulikov in the final, 6–3, 6–7(2–7), [10–7].
Quinn Gleason and Ingrid Neel were the defending champions but Gleason chose not to participate. Neel partnered alongside Alycia Parks but lost in the first round to Irina Bara and Lucrezia Stefanini.
Erin Routliffe and Aldila Sutjiadi were the defending champions, but both players chose not to participate.
Caroline Garcia and Kristina Mladenovic defeated Coco Gauff and Jessica Pegula in the final, 2–6, 6–3, 6–2 to win the women's doubles tennis title at the 2022 French Open. It was their second French Open title as a team. Mladenovic extended her winning streak at the Roland Garros doubles event to 18-consecutive match wins and three titles, having last lost in the quarterfinals of the 2018 tournament.
Mélodie Collard 
Samantha Murray 
Bibiane Schoofs 
