Daniele Bracciali and Potito Starace were the defending champions, but could not defend their title due to being banned from tennis for betting offences.
Chase Buchanan and Blaž Rola were the defending champions but chose not to defend their title.
Johan Brunström and Frederik Nielsen were the defending champions but only Nielsen chose to defend his title, partnering Noah Rubin. Nielsen lost in the first round to Blaž Rola and Grega Žemlja.
Matt Reid and John-Patrick Smith were the defending champions but chose not to defend their title.
The doubles event at the 2017 Milo Open Cali was won by Marcelo Arévalo and Miguel Ángel Reyes-Varela. Nicolás Jarry and Hans Podlipnik-Castillo were the defending champions but chose not to defend their title and did not participate in the 2017 event. Arévalo and Reyes-Varela won the title after defeating Sergio Galdós and Fabrício Neis 6–3, 6–4 in the final.
Ariel Behar and Fabiano de Paula were the defending champions but chose to defend their title with different partners. Behar partnered Attila Balázs but lost in the semifinals to Marcelo Arévalo and Miguel Ángel Reyes-Varela. De Paula partnered Sergio Galdós but lost in the first round to Hugo Dellien and Federico Zeballos.
Austin Krajicek and Jackson Withrow were the defending champions but only Krajicek chose to defend his title, partnering Matt Reid. Krajicek withdrew before the tournament began due to injury.
This was the first edition of the tournament.
Aisam-ul-Haq Qureshi and Rajeev Ram were the defending champions but Ram chose not to participate and Qureshi chose to compete in Båstad instead.
Juan Sebastián Cabal and Treat Huey were the defending champions, but Huey chose not to participate and Cabal chose to compete in Washington instead.
Jonathan Erlich and Neal Skupski were the defending champions but chose to defend their title with different partners. Erlich partnered Ruan Roelofse but lost in the first round to Thanasi Kokkinakis and Matt Reid. Skupski partnered Luke Bambridge but lost in the semifinals to Kokkinakis and Reid.
Christopher Eubanks and Evan King were the defending champions but only King chose to defend his title, partnering Nathan Pasha. King lost in the first round to Thanasi Kokkinakis and Matt Reid.
Leander Paes and Purav Raja were the defending champions but only Paes chose to defend his title, partnering Miguel Ángel Reyes-Varela. Paes lost in the quarterfinals to Alex Lawson and Jackson Withrow.
Marcelo Arévalo and Jeevan Nedunchezhiyan were the defending champions but chose not to defend their title.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions and successfully defended their title, defeating Ariel Behar and Roberto Quiroz 1–6, 6–4, [12–10] in the final.
Gonzalo Escobar and Manuel Sánchez were the defending champions but only Escobar chose to defend his title, partnering Luis David Martínez. Escobar lost in the first round to Adrián Menéndez Maceiras and Federico Zeballos.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions, but lost in the first round to Hans Hach Verdugo and Dennis Novikov.
Leander Paes and Miguel Ángel Reyes-Varela were the defending champions but only Reyes-Varela chose to defend his title, partnering Marcelo Arévalo. Reyes-Varela lost in the semifinals to Orlando Luz and Luis David Martínez.
Marcelo Arévalo and Roberto Maytín were the defending champions but chose to defend their title with different partners. Arévalo partnered Miguel Ángel Reyes-Varela but lost in the first round to Ruben Gonzales and Ruan Roelofse. Maytín partnered Robert Galloway but lost in the first round to Nathan Pasha and Max Schnur.
Thanasi Kokkinakis and Nick Kyrgios defeated Matthew Ebden and Max Purcell in the final, 7–5, 6–4 to win the men's doubles title at the 2022 Australian Open. They became the first all-Australian pair to win the title since Todd Woodbridge and Mark Woodforde in 1997, and the first wildcard champions in the Open Era. The final marked the first all-Australian men's doubles final at the Australian Open since 1980.
Marcelo Arévalo 
Miguel Ángel Reyes-Varela 
Nathan Pasha 
