This was the first edition of the tournament since 1991.
Thomaz Bellucci won the title, defeating João Sousa in the final, 7–6(7–4), 6–4.
Pablo Carreño Busta was the defending champion, but lost in the second round to Julien Benneteau.
Pablo Carreño Busta was the defending champion, but lost to Daniil Medvedev in the second round.
Borna Ćorić was the defending champion, but withdrew before the tournament began.
Two-time defending champion Rafael Nadal successfully defended his title, defeating Stefanos Tsitsipas in the final, 6–2, 6–1. By winning the title, Nadal retained the ATP no. 1 singles ranking. It was Nadal's record-extending eleventh Barcelona Open title and his 20th ATP 500 title overall, equaling Roger Federer's record. It was Tsitsipas' maiden ATP final.
Damir Džumhur was the defending champion, but lost in the quarterfinals to Stan Wawrinka.
Damir Džumhur was the defending champion, but lost to Egor Gerasimov in the first round.
Karen Khachanov was the defending champion, but withdrew before the tournament began.
Roberto Bautista Agut was the defending champion, but lost in the second round to Nikoloz Basilashvili.
Marco Cecchinato was the defending champion, but withdrew due to illness.
Alexander Zverev was the two-time defending champion but chose not to defend his title.
Defending champion Rafael Nadal successfully defended his title, defeating Daniil Medvedev in the final, 6–3, 6–0, to win the men's singles title at the 2019 Canadian Open. This was the first time Nadal defended a hardcourt title.
The 2019 St. Petersburg Open was a tennis tournament played on indoor hard courts. It was the 24th edition of the St. Petersburg Open, and part of the ATP Tour 250 Series of the 2019 ATP Tour. It took place at the Sibur Arena in Saint Petersburg, Russia, from September 16 through 22, 2019.
Novak Djokovic was the defending champion, but lost to Stefanos Tsitsipas in the quarterfinals.
Karen Khachanov was the defending champion, but lost in the quarterfinals to Andreas Seppi.
Stefanos Tsitsipas was the defending champion and successfully defended his title, defeating Félix Auger-Aliassime in the final, 6–3, 6–4.
The tournament was played on a hard surface. Due to the ongoing COVID-19 pandemic and many ATP tournaments having been cancelled, this year's event was upgraded to ATP 500 level.
Roger Federer was the defending champion from when the event was last held in 2019, but lost in the second round to Félix Auger-Aliassime.
Andrey Rublev was the reigning champion from when the tournament was last held in 2019, but lost to Adrian Mannarino in the second round in a rematch of the 2019 final.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Daniil Medvedev 
Borna Ćorić 
