| Singles | |
|---|---|
| 2020 Prosperita Open | |
| Champion |  Aslan Karatsev |
| Runner-up |  Oscar Otte |
| Score | 6–4, 6–2 |
Kamil Majchrzak was the defending champion [1] but chose not to defend his title.
Aslan Karatsev won the title after defeating Oscar Otte 6–4, 6–2 in the final.
Henri Laaksonen (second round)
Ilya Ivashka (quarterfinals)
Chung Hyeon (first round)
Ernests Gulbis (second round)
Martin Kližan (first round)
Arthur Rinderknech (withdrew)
Steven Diez (second round)
Sergiy Stakhovsky (second round, retired)| Semifinals | Final | ||||||||||||
 Botic van de Zandschulp | 3 | 3 | |||||||||||
| SE | Aslan Karatsev | 6 | 6 | ||||||||||
| SE | Aslan Karatsev | 6 | 6 | ||||||||||
| Oscar Otte | 4 | 2 | |||||||||||
| Oscar Otte | 6 | 6 | |||||||||||
| SE | Tallon Griekspoor | 2 | 4 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | H Laaksonen | 7 | 6 | ||||||||||||||||||||||||
| B Schnur | 5 | 1 | 1 | H Laaksonen | 3 | 2 | |||||||||||||||||||||
| WC |  O Virtanen | 5 | 4 | B van de Zandschulp | 6 | 6 | |||||||||||||||||||||
| B van de Zandschulp | 7 | 6 | B van de Zandschulp | 5 | 6 | 6 | |||||||||||||||||||||
| L Lacko | 78 | 6 | L Lacko | 7 | 3 | 1 | |||||||||||||||||||||
| F Horanský | 66 | 2 | L Lacko | 6 | 7 | ||||||||||||||||||||||
 F Ferreira Silva | 77 | 6 | F Ferreira Silva | 4 | 5 | ||||||||||||||||||||||
| 5 | M Kližan | 64 | 2 | B van de Zandschulp | 3 | 3 | |||||||||||||||||||||
| 4 | E Gulbis | 6 | 6 | SE | A Karatsev | 6 | 6 | ||||||||||||||||||||
| WC |  D Svrčina | 4 | 1 | 4 | E Gulbis | 1 | 4 | ||||||||||||||||||||
| SE | A Karatsev | 6 | 6 | SE | A Karatsev | 6 | 6 | ||||||||||||||||||||
| WC | T Macháč | 4 | 4 | SE | A Karatsev | 6 | 6 | ||||||||||||||||||||
| Q | M Moraing | 7 | 6 | Q | M Moraing | 3 | 3 | ||||||||||||||||||||
 R Olivo | 5 | 0 | Q | M Moraing | 6 | 64 | 4 | ||||||||||||||||||||
| P Polansky | 6 | 4 | 3 | 8 | S Stakhovsky | 1 | 77 | 0r | |||||||||||||||||||
| 8 | S Stakhovsky | 4 | 6 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| LL |  M Jaziri | 3 | 5 | ||||||||||||||||||||||||
| Q | Z Kolář | 6 | 7 | Q | Z Kolář | 5 | 6 | 7 | |||||||||||||||||||
| R Safiullin | 3 | 6 | 3 |  D Popko | 7 | 4 | 5 | ||||||||||||||||||||
| D Popko | 6 | 1 | 6 | Q | Z Kolář | 1 | 1 | ||||||||||||||||||||
 A Vukic | 6 | 4 | 3 | O Otte | 6 | 6 | |||||||||||||||||||||
| O Otte | 3 | 6 | 6 | O Otte | 6 | 6 | |||||||||||||||||||||
| L Rosol | 2 | 6 | 6 | L Rosol | 2 | 0 | |||||||||||||||||||||
| 3 | Hy Chung | 6 | 4 | 0 | O Otte | 6 | 6 | ||||||||||||||||||||
| 7 | S Diez | 6 | 6 | SE | T Griekspoor | 2 | 4 | ||||||||||||||||||||
| R Molleker | 1 | 2 | 7 | S Diez | 6 | 2 | 4 | ||||||||||||||||||||
| SE | T Griekspoor | 4 | 6 | 77 | SE | T Griekspoor | 4 | 6 | 6 | ||||||||||||||||||
| R Haase | 6 | 4 | 63 | SE | T Griekspoor | 77 | 6 | ||||||||||||||||||||
| Q | M-A Hüsler | 6 | 4 | 5 | 2 | I Ivashka | 63 | 3 | |||||||||||||||||||
 V Troicki | 3 | 6 | 7 | V Troicki | 3 | 5 | |||||||||||||||||||||
| Q | V Kopřiva | 4 | 64 | 2 | I Ivashka | 6 | 7 | ||||||||||||||||||||
| 2 | I Ivashka | 6 | 77 | ||||||||||||||||||||||||
Kyle Edmund and Frederico Ferreira Silva were the defending champions, but were not eligible to compete this year.
Gianluigi Quinzi was the defending champion, but was no longer eligible to compete in junior tennis, and thus could not defend his title.
Thanasi Kokkinakis and Nick Kyrgios were the defending champions, but were no longer eligible to compete in junior tennis.
Guillermo García López was the defending champion but chose not to defend his title.
Mirza Bašić was the defending champion but lost in the first round to Martin Kližan.
Ričardas Berankis was the defending champion but lost in the semifinals to Kamil Majchrzak.
John Isner was the two-time defending champion and had won the title five times in the last six years, but he lost in the second round to Reilly Opelka. This was only the second time out of ten in the Atlanta Open's history that Isner failed to reach the singles final.
Bernard Tomic was the defending champion, but retired in the first round of the qualifying tournament against Denis Istomin.
Kyle Edmund was the defending champion, but lost in the first round of qualifying to Norbert Gombos.
Pablo Andújar was the defending champion but lost in the final to Kamil Majchrzak.
Dennis Novak was the defending champion but chose not to defend his title.
Gaël Monfils was the defending champion, but chose not to defend his title.
Benoît Paire was the defending champion from when the event was last held in 2019, but chose to participate in Geneva instead.
Marcos Baghdatis was the defending champion but retired from professional tennis in 2019.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Jozef Kovalík was the defending champion but chose not to defend his title.
Jannik Sinner was the defending champion and successfully defended his title, defeating Gaël Monfils in the final, 6–3, 6–4.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Marc-Andrea Hüsler defeated Holger Rune in the final, 6–4, 7–6(10–8) to win the singles tennis title at the 2022 Sofia Open. It was his maiden ATP Tour title, and he saved two match points en route, in his quarterfinal match against Kamil Majchrzak. Hüsler became the fourth Swiss man, after Roger Federer, Stan Wawrinka and Marc Rosset, to win an ATP Tour title in the 21st century.
Ričardas Berankis was the defending champion but chose not to defend his title.