| Singles | |
|---|---|
| 2021 Amex-Istanbul Challenger II | |
| Champion |  James Duckworth |
| Runner-up |  Wu Tung-lin |
| Score | 6–4, 6–2 |
Arthur Rinderknech was the defending champion [1] but chose not to defend his title.
James Duckworth won the title after defeating Wu Tung-lin 6–4, 6–2 in the final.
James Duckworth (champion)
Radu Albot (second round)
Daniel Elahi Galán (first round)
Yasutaka Uchiyama (quarterfinals) Marc Polmans (second round)
Evgeny Donskoy (second round)
Illya Marchenko (second round)
Mohamed Safwat (withdrew)| Semifinals | Final | ||||||||||||
| 1 | James Duckworth | 69 | 6 | 6 | |||||||||
 Quentin Halys | 711 | 3 | 4 | ||||||||||
| 1 | James Duckworth | 6 | 6 | ||||||||||
| Wu Tung-lin | 4 | 2 | |||||||||||
 Borna Gojo | 4 | 6 | 4 | ||||||||||
| Wu Tung-lin | 6 | 3 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | J Duckworth | 7 | 6 | ||||||||||||||||||||||||
 L Giustino | 5 | 1 | 1 | J Duckworth | 6 | 6 | |||||||||||||||||||||
| A Müller | 6 | 6 | A Müller | 3 | 2 | ||||||||||||||||||||||
| Q |  N Chappell | 4 | 2 | 1 | J Duckworth | 6 | 6 | ||||||||||||||||||||
| WC |  S Ağabigün | 4 | 6 | 4 | H Grenier | 3 | 3 | ||||||||||||||||||||
| H Grenier | 6 | 3 | 6 | H Grenier | 6 | 6 | |||||||||||||||||||||
| A Kuznetsov | 64 | 1 | 6 | E Donskoy | 4 | 4 | |||||||||||||||||||||
| 6 | E Donskoy | 77 | 6 | 1 | J Duckworth | 69 | 6 | 6 | |||||||||||||||||||
| 4 | Y Uchiyama | 6 | 3 | 6 | Q Halys | 711 | 3 | 4 | |||||||||||||||||||
| H Moriya | 3 | 6 | 3 | 4 | Y Uchiyama | 3 | 6 | 6 | |||||||||||||||||||
| Q |  Christopher Heyman | 3 | 6 | 6 | Q | C Heyman | 6 | 3 | 4 | ||||||||||||||||||
| A Arnaboldi | 6 | 2 | 4 | 4 | Y Uchiyama | 5 | 2 | ||||||||||||||||||||
| B Tomic | 0 | 1 | Q Halys | 7 | 6 | ||||||||||||||||||||||
| Q Halys | 6 | 6 | Q Halys | 3 | 6 | 6 | |||||||||||||||||||||
| T Fabbiano | 5 | 2 | 7 | I Marchenko | 6 | 2 | 2 | ||||||||||||||||||||
| 7 | I Marchenko | 7 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| LL | G Blancaneaux | 4 | 77 | 6 | |||||||||||||||||||||||
| Q | L Lokoli | 6 | 65 | 1 | LL | G Blancaneaux | 6 | 7 | |||||||||||||||||||
| C-h Tseng | 6 | 2 | 6 | C-h Tseng | 3 | 5 | |||||||||||||||||||||
| R Marcora | 1 | 6 | 4 | LL | G Blancaneaux | 66 | 4 | ||||||||||||||||||||
| E Tiurnev | 5 | 6 | 0 | B Gojo | 78 | 6 | |||||||||||||||||||||
| E Karlovskiy | 7 | 4 | 6 | E Karlovskiy | 1 | 77 | 65 | ||||||||||||||||||||
| B Gojo | 6 | 3 | 6 | B Gojo | 6 | 64 | 77 | ||||||||||||||||||||
| 3 | DE Galán | 4 | 6 | 2 | B Gojo | 4 | 6 | 4 | |||||||||||||||||||
| 5 | M Polmans | 6 | 6 | T-l Wu | 6 | 3 | 6 | ||||||||||||||||||||
| WC | K Kırcı | 3 | 2 | 5 | M Polmans | 2 | 6 | 1 | |||||||||||||||||||
| T Ito | 3 | 2 | T-l Wu | 6 | 3 | 6 | |||||||||||||||||||||
| T-l Wu | 6 | 6 | T-l Wu | 6 | 6 | ||||||||||||||||||||||
| Q |  A Šetkić | 6 | 6 | Q | A Šetkić | 3 | 2 | ||||||||||||||||||||
| WC |  VV Cornea | 4 | 2 | Q | A Šetkić | 4 | 6 | 7 | |||||||||||||||||||
| M Ebden | 4 | 6 | 1 | 2 | R Albot | 6 | 3 | 5 | |||||||||||||||||||
| 2 | R Albot | 6 | 1 | 6 | |||||||||||||||||||||||
James Ward was the defending champion, but lost the re-match of the 2013 final to James Duckworth with the Australian winning the title this year, 6–3, 6–4.
Kei Nishikori was the defending champion, but chose not to participate this year.
Second-seeded Gaël Monfils won the title, defeating Ivo Karlović in the final: 5–7, 7–6(8–6), 6–4.
Kevin Anderson was the defending champion, but lost in the second round to Jiří Veselý.
Yoshihito Nishioka was the defending champion but lost in the quarterfinals to James Duckworth.
Rogério Dutra Silva was the defending champion but chose not to defend his title.
Ričardas Berankis was the defending champion but chose not to defend his title.
Ričardas Berankis was the defending champion but chose not to defend his title.
Scott Clayton and Adil Shamasdin were the defending champions but only Clayton chose to defend his title, partnering Liam Broady. Clayton lost in the quarterfinals to Manuel Guinard and Arthur Rinderknech.
Gaël Monfils was the defending champion, but chose not to defend his title.
Daniil Medvedev defeated Pierre-Hugues Herbert in the final, 6–4, 6–7(4–7), 6–4 to capture the men's singles tennis title at the 2021 Open 13 Provence.
Benoît Paire was the defending champion from when the event was last held in 2019, but chose to participate in Geneva instead.
Ugo Humbert defeated Andrey Rublev in the final 6–3, 7–6(7–4), to win the singles tennis title at the 2021 Halle Open. Humbert's win earned him his third career ATP Tour singles title and his first ATP 500 victory, and also made him the first French player to win the tournament since Henri Leconte won the inaugural edition in 1993. Both Humbert and Rublev were contesting their first career final on grass.
Nicolás Jarry was the reigning champion from when the tournament was last held in 2019, but chose to not defend his title.
Arthur Rinderknech was the defending champion but lost in the semifinals to Benjamin Bonzi.
John Millman was the defending champion, but lost in the quarterfinals to James Duckworth.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
Taylor Fritz defeated Maxime Cressy in the final, 6–2, 6–7(4–7), 7–6(7–4) to win the men's singles tennis title at the 2022 Eastbourne International.
Pablo Carreño Busta defeated Hubert Hurkacz in the final, 3–6, 6–3, 6–3 to win the men's singles tennis title at the 2022 Canadian Open. It was his maiden Masters 1000 title.
Ričardas Berankis was the defending champion but lost in the quarterfinals to Arthur Rinderknech.
Arthur Rinderknech was the defending champion but chose not to defend his title.