| Singles | |
|---|---|
| 2021 Challenger La Manche | |
| Champion |  Ruben Bemelmans |
| Runner-up |  Lukáš Rosol |
| Score | 6–4, 6–4 |
Roman Safiullin was the defending champion [1] but chose not to defend his title.
Ruben Bemelmans won the title after defeating Lukáš Rosol 6–4, 6–4 in the final.
Denis Kudla (second round)
Antoine Hoang (second round) Arthur Rinderknech (semifinals)
Jurij Rodionov (second round)
Peter Gojowczyk (second round)
Bernabé Zapata Miralles (first round) Brandon Nakashima (withdrew) Sebastian Ofner (second round)| Semifinals | Final | ||||||||||||
| Ruben Bemelmans | 6 | 3 | 7 | ||||||||||
| 3 | Arthur Rinderknech | 3 | 6 | 5 | |||||||||
| Ruben Bemelmans | 6 | 6 | |||||||||||
| Lukáš Rosol | 4 | 4 | |||||||||||
| Hugo Gaston | 5 | 6 | 3 | ||||||||||
| Lukáš Rosol | 7 | 2 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Kudla | 6 | 6 | ||||||||||||||||||||||||
| Alt |  N Serdarušić | 3 | 1 | 1 | D Kudla | 1 | 77 | 3 | |||||||||||||||||||
| Q | M Geerts | 62 | 6 | 6 | Q | M Geerts | 6 | 65 | 6 | ||||||||||||||||||
| Q | J Forejtek | 77 | 4 | 2 | Q | M Geerts | 6 | 1 | 64 | ||||||||||||||||||
| R Bemelmans | 3 | 6 | 6 | R Bemelmans | 4 | 6 | 77 | ||||||||||||||||||||
| LL | C Denolly | 6 | 1 | 4 | R Bemelmans | 6 | 77 | ||||||||||||||||||||
 D Istomin | 6 | 5 | 6 | D Istomin | 4 | 64 | |||||||||||||||||||||
| Q | N Lammons | 3 | 7 | 4 | R Bemelmans | 6 | 3 | 7 | |||||||||||||||||||
| 3 | A Rinderknech | 4 | 6 | 6 | 3 | A Rinderknech | 3 | 6 | 5 | ||||||||||||||||||
 A Vatutin | 6 | 0 | 3 | 3 | A Rinderknech | 77 | 6 | ||||||||||||||||||||
 I Sijsling | 2 | 4 | WC | E Furness | 65 | 3 | |||||||||||||||||||||
| WC | E Furness | 6 | 6 | 3 | A Rinderknech | 77 | 77 | ||||||||||||||||||||
| C Lestienne | 1 | 6 | 6 | C Lestienne | 64 | 63 | |||||||||||||||||||||
| Q | T Droguet | 6 | 1 | 2 | C Lestienne | 6 | 6 | ||||||||||||||||||||
| WC | M Martineau | 714 | 6 | WC | M Martineau | 3 | 4 | ||||||||||||||||||||
| 6 | B Zapata Miralles | 612 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | P Gojowczyk | 6 | 6 | ||||||||||||||||||||||||
 T-l Wu | 2 | 4 | 5 | P Gojowczyk | 6 | 3 | 2 | ||||||||||||||||||||
| J Lenz | 1 | 6 | 3 | H Gaston | 4 | 6 | 6 | ||||||||||||||||||||
| H Gaston | 6 | 3 | 6 | H Gaston | 6 | 6 | |||||||||||||||||||||
 G Oliveira | 1 | 4 | Alt |  L Klein | 0 | 3 | |||||||||||||||||||||
| Alt | L Klein | 6 | 6 | Alt | L Klein | 4 | 6 | 6 | |||||||||||||||||||
| WC | K de Schepper | 5 | 6 | 3 | 4 | J Rodionov | 6 | 1 | 3 | ||||||||||||||||||
| 4 | J Rodionov | 7 | 3 | 6 | H Gaston | 5 | 6 | 3 | |||||||||||||||||||
| 8 | S Ofner | 6 | 6 | L Rosol | 7 | 2 | 6 | ||||||||||||||||||||
| Y Maden | 1 | 3 | 8 | S Ofner | 3 | 2 | |||||||||||||||||||||
| M Janvier | 64 | 0r |  K Żuk | 6 | 6 | ||||||||||||||||||||||
| K Żuk | 77 | 1 | K Żuk | 62 | 6 | 62 | |||||||||||||||||||||
| L Rosol | 1 | 6 | 78 | L Rosol | 77 | 4 | 77 | ||||||||||||||||||||
| Alt | A Molčan | 6 | 3 | 66 | L Rosol | 6 | 5 | 7 | |||||||||||||||||||
 M Trungelliti | 1 | 0 | 2 | A Hoang | 3 | 7 | 5 | ||||||||||||||||||||
| 2 | A Hoang | 6 | 6 | ||||||||||||||||||||||||
Filip Peliwo was the champion the previous year, but could not defend his title as he was no longer eligible to compete in junior tennis.
Borna Ćorić won the title, defeating Thanasi Kokkinakis in the final, 3–6, 6–3, 6–1.
Borna Ćorić was the defending champion, having won the event in 2013, but elevated to Men's Singles instead as a qualifier.
Roman Safiullin defeated Hong Seong-chan in the final, 7–5, 7–6(7–2) to win the boys' singles tennis title at the 2015 Australian Open.
Yannick Hanfmann was the defending champion but chose not to defend his title.
Radu Albot was the defending champion but chose not to defend his title.
Ugo Humbert was the defending champion but chose not to defend his title.
Zizou Bergs was the defending champion but lost in the second round to Kacper Żuk.
Evgeny Donskoy was the defending champion but chose not to defend his title.
Max Purcell was the defending champion but chose not to defend his title.
Alexander Bublik defeated Alexander Zverev in the final, 6–4, 6–3 to win the singles title at the 2022 Open Sud de France. It was his maiden ATP Tour title.
Ruben Bemelmans was the defending champion but lost in the quarterfinals to Zizou Bergs.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Zizou Bergs was the defending champion but lost in the quarterfinals to Quentin Halys.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Andrey Rublev defeated Novak Djokovic in the final, 6–2, 6–7(4–7), 6–0 to win the singles tennis title at the 2022 Serbia Open.
Andrey Kuznetsov was the defending champion but chose not to defend his title.
Jason Kubler was the defending champion but chose not to defend his title.
Félix Auger-Aliassime defeated J. J. Wolf in the final, 6–4, 6–4 to win the singles tennis title at the 2022 Firenze Open. It was his second ATP Tour singles title.
Tomáš Macháč was the defending champion but chose not to defend his title.
Roman Safiullin was the defending champion but chose not to defend his title.