| Singles | |
|---|---|
| 2021 Città di Como Challenger | |
| Champion |  Juan Manuel Cerúndolo |
| Runner-up |  Gian Marco Moroni |
| Score | 7–5, 7–6(9–7) |
Facundo Mena was the defending champion [1] but chose not to defend his title.
Juan Manuel Cerúndolo won the title after defeating Gian Marco Moroni 7–5, 7–6(9–7) in the final.
Daniel Altmaier (semifinals, retired)
Jozef Kovalík (quarterfinals) Andrej Martin (second round) Juan Manuel Cerúndolo (champion) Federico Gaio (second round)
Sumit Nagal (first round)
Marc-Andrea Hüsler (first round) Alessandro Giannessi (withdrew)| Semifinals | Final | ||||||||||||
| 1 | Daniel Altmaier | 4 | 0r | ||||||||||
| 4 | Juan Manuel Cerúndolo | 6 | 3 | ||||||||||
| 4 | Juan Manuel Cerúndolo | 7 | 79 | ||||||||||
| Gian Marco Moroni | 5 | 67 | |||||||||||
| Gian Marco Moroni | 6 | 3 | 4 | ||||||||||
| Q | Andrea Vavassori | 3 | 6 | 0r | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Altmaier | 6 | 6 | ||||||||||||||||||||||||
 J Domingues | 2 | 0 | 1 | D Altmaier | 6 | 7 | |||||||||||||||||||||
 J Menezes | 4 | J Menezes | 0 | 5 | |||||||||||||||||||||||
| Alt |  E Furness | 1r | 1 | D Altmaier | 77 | 6 | |||||||||||||||||||||
| WC | Federico Iannaccone | 5 | 6 | 6 | R Bonadio | 63 | 3 | ||||||||||||||||||||
| SE | C Ugo Carabelli | 7 | 3 | 4 | WC | F Iannaccone | 2 | 1 | |||||||||||||||||||
| R Bonadio | 3 | 6 | 6 | R Bonadio | 6 | 6 | |||||||||||||||||||||
| Q |  A Erler | 6 | 3 | 3 | 1 | D Altmaier | 4 | 0r | |||||||||||||||||||
| 4 | JM Cerúndolo | 6 | 77 | 4 | JM Cerúndolo | 6 | 3 | ||||||||||||||||||||
| T Lamasine | 4 | 62 | 4 | JM Cerúndolo | 5 | ||||||||||||||||||||||
| Q | L Miedler | 6 | 2 | 4 | Alt | G Zeppieri | 0r | ||||||||||||||||||||
| Alt | G Zeppieri | 4 | 6 | 6 | 4 | JM Cerúndolo | 7 | 6 | |||||||||||||||||||
| PR |  J Cagnina | 1 | 3r | SE |  N Serdarušić | 5 | 2 | ||||||||||||||||||||
| WC | F Cobolli | 6 | 3 | WC | F Cobolli | 4 | 0 | ||||||||||||||||||||
| SE | N Serdarušić | 6 | 6 | SE | N Serdarušić | 6 | 6 | ||||||||||||||||||||
| 7 | M-A Hüsler | 4 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | F Gaio | 6 | 3 | 6 | |||||||||||||||||||||||
| Q |  P Chrysochos | 1 | 6 | 3 | 5 | F Gaio | 5 | 1 | |||||||||||||||||||
| LL |  A Vatutin | 0r | GM Moroni | 7 | 6 | ||||||||||||||||||||||
| GM Moroni | 3 | GM Moroni | 6 | 4 | 6 | ||||||||||||||||||||||
| PR | A Arnaboldi | 77 | 6 | PR | A Arnaboldi | 3 | 6 | 2 | |||||||||||||||||||
| T Gabashvili | 65 | 2 | PR | A Arnaboldi | 4 | 6 | 6 | ||||||||||||||||||||
| WC | F Forti | 7 | 2 | 1 | 3 | A Martin | 6 | 4 | 3 | ||||||||||||||||||
| 3 | A Martin | 5 | 6 | 6 | GM Moroni | 6 | 3 | 4 | |||||||||||||||||||
| 6 | S Nagal | 4 | 64 | Q | A Vavassori | 3 | 6 | 0r | |||||||||||||||||||
| A Kuznetsov | 6 | 77 | A Kuznetsov | 6 | 3 | 4 | |||||||||||||||||||||
 J Draper | 4 | 6 | 3 | Q | A Vavassori | 2 | 6 | 6 | |||||||||||||||||||
| Q | A Vavassori | 6 | 2 | 6 | Q | A Vavassori | 6 | 6 | |||||||||||||||||||
| N Borges | 3 | 1 | 2 | J Kovalík | 3 | 4 | |||||||||||||||||||||
| LL | F Agamenone | 6 | 6 | LL | F Agamenone | 2 | 61 | ||||||||||||||||||||
| PR | J Lenz | 5 | 2 | 2 | J Kovalík | 6 | 77 | ||||||||||||||||||||
| 2 | J Kovalík | 7 | 6 | ||||||||||||||||||||||||
Axel Geller and Hsu Yu-hsiou were the defending champions, but both players were ineligible to participate in junior events.
Cristian Garín was the defending champion but chose not to defend his title.
Guido Andreozzi and Guillermo Durán were the defending champions but only Durán chose to defend his title, partnering Mariano Kestelboim. Durán lost in the first round to Facundo Mena and Camilo Ugo Carabelli.
Cristian Garín was the defending champion, but chose not to defend his title.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Miomir Kecmanović was the defending champion, but chose to compete at the Summer Olympics instead.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
Pedro Sousa was the defending champion but chose not to defend his title.
Tallon Griekspoor was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Sebastián Báez was the defending champion but lost in the final to Juan Pablo Varillas.
Juan Pablo Varillas was the defending champion but lost in the quarterfinals to Marcelo Tomás Barrios Vera.
Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Francisco Cerúndolo was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion but chose not to defend his title.
Francisco Cerúndolo was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion but chose not to defend his title.
Camilo Ugo Carabelli was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion and successfully defended his title, defeating Jesper de Jong 6–3, 2–6, 6–2 in the final.