| Men's singles | |
|---|---|
| 2021 Columbus Challenger | |
| Champion |  Stefan Kozlov |
| Runner-up |  Max Purcell |
| Score | 4–6, 6–2, 6–4 |
J. J. Wolf was the defending champion [1] but lost in the semifinals to Stefan Kozlov.
Kozlov won the title after defeating Max Purcell 4–6, 6–2, 6–4 in the final.
Tennys Sandgren (quarterfinals)
Salvatore Caruso (first round, retired) Alex Bolt (quarterfinals)
Prajnesh Gunneswaran (second round)
Jason Jung (first round) Ernesto Escobedo (first round) J. J. Wolf (semifinals) Mitchell Krueger (first round)| Semifinals | Final | ||||||||||||
| 7 | J. J. Wolf | 6 | 3 | 5 | |||||||||
| Stefan Kozlov | 2 | 6 | 7 | ||||||||||
| Stefan Kozlov | 4 | 6 | 6 | ||||||||||
| Max Purcell | 6 | 2 | 4 | ||||||||||
| Aleksandar Vukic | 63 | 66 | |||||||||||
| Max Purcell | 77 | 78 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | T Sandgren | 6 | 6 | ||||||||||||||||||||||||
| LL |  A Galarneau | 3 | 2 | 1 | T Sandgren | 6 | 6 | ||||||||||||||||||||
| Q |  G Brouwer | 77 | 6 | Q | G Brouwer | 4 | 4 | ||||||||||||||||||||
 D King | 61 | 0 | 1 | T Sandgren | 3 | 6 | 65 | ||||||||||||||||||||
| JC Aragone | 4 | 4 | 7 | J. J. Wolf | 6 | 3 | 77 | ||||||||||||||||||||
| Q | E King | 6 | 6 | Q | E King | 3 | 0 | ||||||||||||||||||||
| M Sasikumar | 3 | 2 | 7 | J. J. Wolf | 6 | 6 | |||||||||||||||||||||
| 7 | J. J. Wolf | 6 | 6 | 7 | J. J. Wolf | 6 | 3 | 5 | |||||||||||||||||||
| 4 | P Gunneswaran | 3 | 6 | 7 | S Kozlov | 2 | 6 | 7 | |||||||||||||||||||
| Q | A Kovacevic | 6 | 3 | 5 | 4 | P Gunneswaran | 1 | 4 | |||||||||||||||||||
| LL |  S Mochizuki | 3 | 77 | 65 |  M Torpegaard | 6 | 6 | ||||||||||||||||||||
| M Torpegaard | 6 | 63 | 77 | M Torpegaard | 6 | 64 | 4 | ||||||||||||||||||||
| J Kubler | 78 | 6 | S Kozlov | 2 | 77 | 6 | |||||||||||||||||||||
| P Polansky | 66 | 4 | J Kubler | 2 | 5 | ||||||||||||||||||||||
| S Kozlov | 6 | 6 | S Kozlov | 6 | 7 | ||||||||||||||||||||||
| 8 | M Krueger | 0 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | E Escobedo | 4 | 5 | ||||||||||||||||||||||||
| A Vukic | 6 | 7 | A Vukic | 77 | 7 | ||||||||||||||||||||||
| WC |  Matěj Vocel | 7 | 1 | 63 | WC | C Kingsley | 64 | 5 | |||||||||||||||||||
| WC | C Kingsley | 5 | 6 | 77 | A Vukic | 7 | 6 | ||||||||||||||||||||
| Q |  Y-s Chung | 6 | 4 | 63 | 3 | A Bolt | 5 | 4 | |||||||||||||||||||
| J-s Nam | 3 | 6 | 77 | J-s Nam | 65 | 4 | |||||||||||||||||||||
| N Rubin | 65 | 64 | 3 | A Bolt | 77 | 6 | |||||||||||||||||||||
| 3 | A Bolt | 77 | 77 | A Vukic | 63 | 66 | |||||||||||||||||||||
| 5 | J Jung | 3 | 4 | M Purcell | 77 | 78 | |||||||||||||||||||||
 R Peniston | 6 | 6 | R Peniston | 3 | 67 | ||||||||||||||||||||||
| WC | J Tracy | 3 | 2 | M Purcell | 6 | 79 | |||||||||||||||||||||
| M Purcell | 6 | 6 | M Purcell | 6 | 3 | 6 | |||||||||||||||||||||
| Alt | N Chappell | 0r |  N Mejía | 4 | 6 | 0 | |||||||||||||||||||||
| N Mejía | 5 | N Mejía | 6 | 0 | 6 | ||||||||||||||||||||||
| Alt | D Kelly | 6 | 3 | Alt | D Kelly | 4 | 6 | 2 | |||||||||||||||||||
| 2 | S Caruso | 2 | 0r | ||||||||||||||||||||||||
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