| Singles | |
|---|---|
| 2021 Internationaux de Tennis de Vendée | |
| Champion |  Jiří Veselý |
| Runner-up |  Norbert Gombos |
| Score | 6–4, 6–4 |
Mikael Ymer was the defending champion [1] but chose not to defend his title.
Jiří Veselý won the title after defeating Norbert Gombos 6–4, 6–4 in the final.
Benjamin Bonzi (first round) Jiří Veselý (champion)
Peter Gojowczyk (first round)
Andreas Seppi (semifinals) Gilles Simon (first round, withdrew) Pierre-Hugues Herbert (quarterfinals)
Ričardas Berankis (second round) Norbert Gombos (final)| Semifinals | Final | ||||||||||||
| Q | Mats Rosenkranz | 4 | 64 | ||||||||||
| 8 | Norbert Gombos | 6 | 77 | ||||||||||
| 8 | Norbert Gombos | 4 | 4 | ||||||||||
| 2 | Jiří Veselý | 6 | 6 | ||||||||||
| 4 | Andreas Seppi | 4 | 61 | ||||||||||
| 2 | Jiří Veselý | 6 | 77 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | B Bonzi | 64 | 4 | ||||||||||||||||||||||||
| Q | M Rosenkranz | 77 | 6 | Q | M Rosenkranz | 6 | 3 | ||||||||||||||||||||
 K Majchrzak | 77 | 3 | 6 | K Majchrzak | 4 | 1r | |||||||||||||||||||||
| Q |  E Karlovskiy | 65 | 6 | 3 | Q | M Rosenkranz | 62 | 6 | 77 | ||||||||||||||||||
 R Bemelmans | 3 | 6 | 5 | 6 | P-H Herbert | 77 | 3 | 64 | |||||||||||||||||||
| Alt | C Lestienne | 6 | 3 | 7 | Alt | C Lestienne | 6 | 65 | 4 | ||||||||||||||||||
| WC | K Jacquet | 1 | 3 | 6 | P-H Herbert | 3 | 77 | 6 | |||||||||||||||||||
| 6 | P-H Herbert | 6 | 6 | Q | M Rosenkranz | 4 | 64 | ||||||||||||||||||||
| 3 | P Gojowczyk | 3 | 6 | 3 | 8 | N Gombos | 6 | 77 | |||||||||||||||||||
 D Novak | 6 | 4 | 6 | D Novak | 77 | 6 | |||||||||||||||||||||
| L Pouille | 2 | 62 |  E Ymer | 61 | 4 | ||||||||||||||||||||||
| E Ymer | 6 | 77 | D Novak | 6 | 3 | 2 | |||||||||||||||||||||
| T Kamke | 2 | 63 | 8 | N Gombos | 4 | 6 | 6 | ||||||||||||||||||||
| LL | K de Schepper | 6 | 77 | LL | K de Schepper | 61 | 64 | ||||||||||||||||||||
| R Safiullin | 4 | 5 | 8 | N Gombos | 77 | 77 | |||||||||||||||||||||
| 8 | N Gombos | 6 | 7 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | R Berankis | 77 | 6 | ||||||||||||||||||||||||
| Q | T Droguet | 60 | 2 | 7 | R Berankis | 64 | 5 | ||||||||||||||||||||
| Q Halys | 7 | 77 | Q Halys | 77 | 7 | ||||||||||||||||||||||
| G Barrère | 5 | 65 | Q Halys | 6 | 66 | 3 | |||||||||||||||||||||
| T Macháč | 6 | 6 | 4 | A Seppi | 2 | 78 | 6 | ||||||||||||||||||||
 B Gojo | 2 | 4 | T Macháč | 63 | 6 | 4 | |||||||||||||||||||||
 F Verdasco | 5 | 1 | 4 | A Seppi | 77 | 4 | 6 | ||||||||||||||||||||
| 4 | A Seppi | 7 | 6 | 4 | A Seppi | 4 | 61 | ||||||||||||||||||||
| 5 | G Simon | 2 | J Veselý | 6 | 77 | ||||||||||||||||||||||
| M Moraing | w/o | M Moraing | 6 | 62 | 6 | ||||||||||||||||||||||
| WC | A Fils | 62 | 3 | Q | Z Bergs | 4 | 77 | 4 | |||||||||||||||||||
| Q | Z Bergs | 77 | 6 | M Moraing | 1r | ||||||||||||||||||||||
| A Hoang | 64 | 3 | 2 | J Veselý | 4 | ||||||||||||||||||||||
| WC | H Mayot | 77 | 6 | WC | H Mayot | 2 | 4 | ||||||||||||||||||||
 F Ferreira Silva | 6 | 3 | 2 | 2 | J Veselý | 6 | 6 | ||||||||||||||||||||
| 2 | J Veselý | 3 | 6 | 6 | |||||||||||||||||||||||
Radek Štěpánek was the defending champion, but lost in the semifinals to Jiří Veselý.
David Goffin was the defending champion, but withdrew before the tournament began.
Martin Kližan was the defending champion, but withdrew before the tournament began.
Elias Ymer was the defending champion but lost in the first round to Lukáš Rosol.
Mikhail Kukushkin was the defending champion but lost in the first round to Nicolás Jarry.
Marin Čilić was the defending champion, but lost in the second round to Malek Jaziri.
Filip Krajinović was the defending champion but chose not to defend his title.
Jiří Veselý was the defending champion but lost in the second round to Elias Ymer.
Arthur De Greef was the defending champion but lost in the third round to Tomáš Macháč.
Elias Ymer was the defending champion but chose not to defend his title.
Hubert Hurkacz was the defending champion but chose not to defend his title.
Alexander Bublik was the defending champion but chose not to defend his title.
Alexander Bublik was the defending champion but chose not to defend his title.
Alex de Minaur defeated Lorenzo Sonego in the final, 4–6, 6–4, 7–6(7–5), to win the men's singles tennis title at the 2021 Eastbourne International. It was De Minaur's fifth career ATP Tour singles title and his first on grass. Sonego was contesting in his second grass final to win his third career title.
Mikael Ymer was the defending champion but chose not to defend his title.
João Sousa defeated Emil Ruusuvuori in the final, 7–6(11–9), 4–6, 6–1 to win the singles title at the 2022 Tata Open Maharashtra. Sousa saved three match points against Elias Ymer in the semifinals. This was his first title since 2018.
Federico Coria was the defending champion but lost in the first round to Dalibor Svrčina.
Facundo Bagnis was the defending champion but lost in the semifinals to Thiago Monteiro.
Jannik Sinner defeated the defending champion Carlos Alcaraz in the final, 6–7(5–7), 6–1, 6–1 to win the singles tennis title at the 2022 Croatia Open Umag.
Jiří Veselý was the defending champion but chose not to defend his title.