| Singles | |
|---|---|
| 2021 Knoxville Challenger | |
| Champion |  Christopher Eubanks |
| Runner-up |  Daniel Altmaier |
| Score | 6–3, 6–4 |
Michael Mmoh was the defending champion [1] but lost in the semifinals to Daniel Altmaier.
Christopher Eubanks won the title after defeating Altmaier 6–3, 6–4 in the final.
Tennys Sandgren (first round) Daniel Altmaier (final)
Vasek Pospisil (first round) Mitchell Krueger (second round) Jack Sock (quarterfinals) J. J. Wolf (first round)
Dmitry Popko (first round) Bjorn Fratangelo (semifinals)| Semifinals | Final | ||||||||||||
| 8 | Bjorn Fratangelo | 5 | 5 | ||||||||||
| Christopher Eubanks | 7 | 7 | |||||||||||
| Christopher Eubanks | 6 | 6 | |||||||||||
| 2 | Daniel Altmaier | 3 | 4 | ||||||||||
| Michael Mmoh | 6 | 3 | 4 | ||||||||||
| 2 | Daniel Altmaier | 3 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | T Sandgren | 6 | 63 | 64 | |||||||||||||||||||||||
| Alt | P Polansky | 3 | 77 | 77 | Alt | P Polansky | 6 | 62 | 0r | ||||||||||||||||||
| WC | Em Nava | 6 | 6 | WC | Em Nava | 2 | 77 | 0 | |||||||||||||||||||
| Q | D Young | 3 | 2 | WC | Em Nava | 4 | 4 | ||||||||||||||||||||
| Q |  G Brouwer | 5 | 6 | 7 | 8 | B Fratangelo | 6 | 6 | |||||||||||||||||||
| Q | JC Aragone | 7 | 2 | 5 | Q | G Brouwer | 3 | 6 | 3 | ||||||||||||||||||
 Yo Watanuki | 4 | 65 | 8 | B Fratangelo | 6 | 3 | 6 | ||||||||||||||||||||
| 8 | B Fratangelo | 6 | 77 | 8 | B Fratangelo | 5 | 5 | ||||||||||||||||||||
| 3 | V Pospisil | 6 | 2 | 3 | C Eubanks | 7 | 7 | ||||||||||||||||||||
| C Eubanks | 2 | 6 | 6 | C Eubanks | 6 | 2 | 77 | ||||||||||||||||||||
| G Soeda | 6 | 78 | G Soeda | 3 | 6 | 64 | |||||||||||||||||||||
| Alt |  M Jaziri | 4 | 66 | C Eubanks | 6 | 711 | |||||||||||||||||||||
 J Jung | 6 | 6 | Alt | C Harrison | 3 | 69 | |||||||||||||||||||||
 J Kubler | 4 | 1 | J Jung | 6 | 63 | 2r | |||||||||||||||||||||
| Alt | C Harrison | 6 | 6 | Alt | C Harrison | 3 | 77 | 4 | |||||||||||||||||||
| 6 | J. J. Wolf | 2 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | D Popko | 4 | 5 | ||||||||||||||||||||||||
| Q |  A McHugh | 6 | 7 | Q | A McHugh | 6 | 6 | ||||||||||||||||||||
| A Vukic | 3 | 6 | 5 | S Kozlov | 4 | 4 | |||||||||||||||||||||
| S Kozlov | 6 | 4 | 7 | Q | A McHugh | 6 | 3 | 1 | |||||||||||||||||||
| Y Uchiyama | 5 | 3 | M Mmoh | 3 | 6 | 6 | |||||||||||||||||||||
| M Mmoh | 7 | 6 | M Mmoh | 77 | 1 | 6 | |||||||||||||||||||||
| PR | T Ito | 64 | 3 | 4 | M Krueger | 64 | 6 | 2 | |||||||||||||||||||
| 4 | M Krueger | 77 | 6 | M Mmoh | 6 | 3 | 4 | ||||||||||||||||||||
| 5 | J Sock | 77 | 7 | 2 | D Altmaier | 3 | 6 | 6 | |||||||||||||||||||
| WC | A Kovacevic | 64 | 5 | 5 | J Sock | 6 | 77 | ||||||||||||||||||||
 P Gunneswaran | 6 | 77 | P Gunneswaran | 3 | 61 | ||||||||||||||||||||||
 M Torpegaard | 2 | 62 | 5 | J Sock | 6 | 5 | 62 | ||||||||||||||||||||
 B Rola | 6 | 77 | 2 | D Altmaier | 3 | 7 | 77 | ||||||||||||||||||||
| T-S Kwiatkowski | 3 | 65 | B Rola | 63 | 4 | ||||||||||||||||||||||
| WC | A Walton | 3 | 2 | 2 | D Altmaier | 77 | 6 | ||||||||||||||||||||
| 2 | D Altmaier | 6 | 6 | ||||||||||||||||||||||||
Daniel Evans was the defending champion but lost in the second round to Peter Polansky.
Stan Wawrinka was the defending champion and successfully defended his title, defeating Mischa Zverev in the final, 4–6, 6–3, 6–3.
Michael Mmoh was the defending champion but lost in the second round to Brandon Nakashima.
Botic van de Zandschulp was the defending champion but withdrew before his semifinal match against Taro Daniel.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
This was the third edition of the tournament, primarily created due to the one-week delay of the 2021 French Open.
Carlos Alcaraz defeated Richard Gasquet in the final, 6–2, 6–2 to win the singles tennis title at the 2021 Croatia Open. It was his first ATP Tour title. With the victory, Alcaraz became the youngest player to win an ATP Tour title since Kei Nishikori at the 2008 Delray Beach International Tennis Championships.
This was the first edition of the tournament.
Marcelo Arévalo was the defending champion but chose not to defend his title.
J. J. Wolf was the defending champion but lost in the semifinals to Stefan Kozlov.
Sebastian Ofner was the defending champion but chose not to defend his title.
Aslan Karatsev defeated Andy Murray in the final, 6–3, 6–3 to win the men's singles title at the 2022 Sydney Tennis Classic. This was Murray's first ATP final since he won the 2019 European Open.
João Sousa defeated Emil Ruusuvuori in the final, 7–6(11–9), 4–6, 6–1 to win the singles title at the 2022 Tata Open Maharashtra. Sousa saved three match points against Elias Ymer in the semifinals. This was his first title since 2018.
Jenson Brooksby was the defending champion but chose not to defend his title.
Bernabé Zapata Miralles was the defending champion but lost in the quarterfinals to Andrej Martin.
Daniel Altmaier was the defending champion but chose not to defend his title.
Daniel Altmaier was the defending champion but chose not to defend his title.
Nick Kyrgios defeated Yoshihito Nishioka in the final, 6–4, 6–3 to win the men's singles tennis title at the 2022 Washington Open. It was his second Washington title, following 2019. Kyrgios saved five match points en route to the title, in the quarterfinals against Frances Tiafoe. He also did not drop serve during the tournament.
Camilo Ugo Carabelli was the defending champion but lost in the second round to Giovanni Mpetshi Perricard.
Alejandro Tabilo was the defending champion but chose not to defend his title.