| Singles | |
|---|---|
| 2021 Meerbusch Challenger | |
| Champion |  Tomás Barrios Vera |
| Runner-up |  Juan Manuel Cerúndolo |
| Score | 7–6(9–7), 6–3 |
Pedro Sousa was the defending champion [1] but chose not to defend his title.
Marcelo Tomás Barrios Vera won the title after defeating Juan Manuel Cerúndolo 7–6(9–7), 6–3 in the final.
Daniel Altmaier (quarterfinals)
Damir Džumhur (second round)
Botic van de Zandschulp (semifinals) Oscar Otte (second round) Juan Manuel Cerúndolo (final)
Tomáš Macháč (first round)
Alex Molčan (withdrew)
Sumit Nagal (first round)| Semifinals | Final | ||||||||||||
| Marcelo Tomás Barrios Vera | 6 | 4 | 6 | ||||||||||
| Robin Haase | 3 | 6 | 2 | ||||||||||
| Marcelo Tomás Barrios Vera | 79 | 6 | |||||||||||
| 5 | Juan Manuel Cerúndolo | 67 | 3 | ||||||||||
| 3 | Botic van de Zandschulp | 5 | 4 | ||||||||||
| 5 | Juan Manuel Cerúndolo | 7 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Altmaier | 6 | 7 | ||||||||||||||||||||||||
| A Tabilo | 0 | 5 | 1 | D Altmaier | 77 | 3 | 6 | ||||||||||||||||||||
| V Kopřiva | 7 | 6 | V Kopřiva | 63 | 6 | 3 | |||||||||||||||||||||
| LL | N Fatić | 5 | 2 | 1 | D Altmaier | 4 | 6 | 64 | |||||||||||||||||||
 N Kuhn | 6 | 6 | MT Barrios Vera | 6 | 1 | 77 | |||||||||||||||||||||
| Q |  N Hardt | 4 | 3 | N Kuhn | |||||||||||||||||||||||
| MT Barrios Vera | 7 | 4 | 6 | MT Barrios Vera | w/o | ||||||||||||||||||||||
| 8 | S Nagal | 5 | 6 | 3 | MT Barrios Vera | 6 | 4 | 6 | |||||||||||||||||||
| 4 | O Otte | 6 | 6 | R Haase | 3 | 6 | 2 | ||||||||||||||||||||
| WC | M Rosenkranz | 4 | 4 | 4 | O Otte | 6 | 5 | 3 | |||||||||||||||||||
| Q | J de Jong | 3 | 77 | 4 | R Haase | 3 | 7 | 6 | |||||||||||||||||||
| R Haase | 6 | 65 | 6 | R Haase | 4 | 6 | 6 | ||||||||||||||||||||
| Q | N Kicker | 6 | 6 | M Moraing | 6 | 3 | 3 | ||||||||||||||||||||
| JP Ficovich | 4 | 3 | Q | N Kicker | 4 | 2 | |||||||||||||||||||||
| M Moraing | 77 | 6 | M Moraing | 6 | 6 | ||||||||||||||||||||||
| 6 | T Macháč | 60 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| Q |  D Ajduković | 6 | 63 | 7 | |||||||||||||||||||||||
| WC |  S Mochizuki | 3 | 77 | 5 | Q | D Ajduković | 4 | 6 | 4 | ||||||||||||||||||
| L Klein | 6 | 6 | L Klein | 6 | 4 | 6 | |||||||||||||||||||||
| T Kamke | 1 | 2 | L Klein | 4 | 6 | 4 | |||||||||||||||||||||
 R Safiullin | 4 | 77 | 4 | 3 | B van de Zandschulp | 6 | 3 | 6 | |||||||||||||||||||
 C Lestienne | 6 | 63 | 6 | C Lestienne | 4 | 6 | 4 | ||||||||||||||||||||
| R Cid Subervi | 6 | 4 | 64 | 3 | B van de Zandschulp | 6 | 3 | 6 | |||||||||||||||||||
| 3 | B van de Zandschulp | 3 | 6 | 77 | 3 | B van de Zandschulp | 5 | 4 | |||||||||||||||||||
| 5 | JM Cerúndolo | 2 | 6 | 6 | 5 | JM Cerúndolo | 7 | 6 | |||||||||||||||||||
 K Coppejans | 6 | 2 | 2 | 5 | JM Cerúndolo | 6 | 77 | ||||||||||||||||||||
| WC | R Molleker | 6 | 3 | 2 | M Marterer | 4 | 63 | ||||||||||||||||||||
| M Marterer | 3 | 6 | 6 | 5 | JM Cerúndolo | 3 | 6 | 7 | |||||||||||||||||||
| F Horanský | 6 | 6 | F Horanský | 6 | 1 | 5 | |||||||||||||||||||||
| A Collarini | 4 | 2 | F Horanský | 77 | 2 | 6 | |||||||||||||||||||||
| R Bemelmans | 3 | 3 | 2 | D Džumhur | 64 | 6 | 2 | ||||||||||||||||||||
| 2 | D Džumhur | 6 | 6 | ||||||||||||||||||||||||
Cristian Garín was the defending champion, but chose not to defend his title.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
Facundo Mena was the defending champion but chose not to defend his title.
Tallon Griekspoor was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Sebastián Báez was the defending champion but lost in the final to Juan Pablo Varillas.
Juan Pablo Varillas was the defending champion but lost in the quarterfinals to Marcelo Tomás Barrios Vera.
Sumit Nagal was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Francisco Cerúndolo defeated Sebastián Báez in the final, 7–6(7–4), 6–2 to win the men's singles tennis title at the 2022 Swedish Open. It was his maiden ATP Tour title.
Facundo Díaz Acosta was the defending champion but lost in the final to Juan Manuel Cerúndolo.
Camilo Ugo Carabelli was the defending champion but lost in the second round to Giovanni Mpetshi Perricard.
Alejandro Tabilo was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but chose not to defend his title.
Cameron Norrie defeated the defending champion Carlos Alcaraz in the final, 5–7, 6–4, 7–5 to win the singles tennis title at the 2023 Rio Open. It was their second final meeting in as many weeks, with Alcaraz winning the title in Buenos Aires the week prior.
Nicolás Jarry defeated Tomás Martín Etcheverry in the final, 6–7(5–7), 7–6(7–5), 6–2 to win the singles tennis title at the 2023 Chile Open. This was Jarry's first ATP title since 2019.
Kaichi Uchida was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Pedro Cachin was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion but lost in the quarterfinals to Luciano Darderi.