40S ribosomal protein S4, Y isoform 1

RPS4Y1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AJ0, 5FLX, 4D61, 4D5L, 4UJD, 4UJE, 4UJC
Identifiers
Aliases	RPS4Y1 , RPS4Y, S4, ribosomal protein S4, Y-linked 1, ribosomal protein S4 Y-linked 1
External IDs	OMIM: 470000 MGI: 98158 HomoloGene: 133576 GeneCards: RPS4Y1
Gene location (Mouse) Chr. X chromosome (mouse) [1] Band X D|X 45.2 cM Start 101,228,547 bp [1] End 101,233,000 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis prostate human penis right lung corpus epididymis rectum trabecular bone urethra synovial joint seminal vesicula Top expressed in ganglionic eminence uterus zone of skin spleen esophagus thymus urinary bladder lens colon ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding structural constituent of ribosome RNA binding Cellular component ribosome polysome cytosol nucleus membrane intracellular anatomical structure nucleoplasm cytosolic small ribosomal subunit Biological process SRP-dependent cotranslational protein targeting to membrane viral transcription multicellular organism development nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6192 20102 Ensembl n/a ENSMUSG00000031320 UniProt P22090 P62702 RefSeq (mRNA) NM_001008 NM_009094 RefSeq (protein) NP_000999 NP_033120 Location (UCSC) n/a Chr X: 101.23 – 101.23 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S4, Y isoform 1 is a protein that in humans is encoded by the RPS4Y1 gene. ^{[4] [5] [6]}

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene, RPS4Y2 and the ribosomal protein S4, X-linked (RPS4X). The 3 isoforms encoded by these genes are not identical, but appear to be functionally equivalent. ^[7] Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. ^[4]

See also

• S4 protein domain

References

1. GRCm38: Ensembl release 89: ENSMUSG00000031320 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1".
5. Fisher EM, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Lawrence JB, Willard HF, Bieber FR, Page DC (December 1990). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome". Cell. 63 (6): 1205–18. doi:10.1016/0092-8674(90)90416-C. PMID   2124517. S2CID   16060228.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. Andrés O, Kellermann T, López-Giráldez F, Rozas J, Domingo-Roura X, Bosch M (2008). "RPS4Y gene family evolution in primates". BMC Evol. Biol. 8 (1): 142. Bibcode:2008BMCEE...8..142A. doi: 10.1186/1471-2148-8-142 . PMC   2397393 . PMID   18477388.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Fisher EM, Beer-Romero P, Brown LG, et al. (1991). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome". Cell. 63 (6): 1205–18. doi:10.1016/0092-8674(90)90416-C. PMID   2124517. S2CID   16060228.
• Weller PA, Critcher R, Goodfellow PN, et al. (1995). "The human Y chromosome homologue of XG: transcription of a naturally truncated gene". Hum. Mol. Genet. 4 (5): 859–68. doi:10.1093/hmg/4.5.859. PMID   7633446.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Zinn AR, Alagappan RK, Brown LG, et al. (1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes". Mol. Cell. Biol. 14 (4): 2485–92. doi:10.1128/mcb.14.4.2485. PMC   358616 . PMID   8139551.
• Watanabe M, Zinn AR, Page DC, Nishimoto T (1993). "Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome". Nat. Genet. 4 (3): 268–71. doi:10.1038/ng0793-268. PMID   8358435. S2CID   11495083.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Omoe K, Endo A (1996). "Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs". Genomics. 31 (1): 44–50. doi:10.1006/geno.1996.0007. PMID   8808278.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Bakay M, Zhao P, Chen J, Hoffman EP (2002). "A web-accessible complete transcriptome of normal human and DMD muscle". Neuromuscul. Disord. 12. Suppl 1: S125–41. doi:10.1016/S0960-8966(02)00093-7. PMID   12206807. S2CID   28217741.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi: 10.1038/nature01722 . PMID   12815422.
• Vawter MP, Evans S, Choudary P, et al. (2004). "Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes". Neuropsychopharmacology. 29 (2): 373–84. doi:10.1038/sj.npp.1300337. PMC   3130534 . PMID   14583743.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi: 10.1093/molbev/msh027 . PMID   14660691.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.