ABLIM3

ABLIM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UJS, 2DJ7
Identifiers
Aliases	ABLIM3 , HMFN1661, actin binding LIM protein family member 3
External IDs	OMIM: 611305; MGI: 2442582; HomoloGene: 69175; GeneCards: ABLIM3; OMA:ABLIM3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q32 Start 149,141,483 bp [1] End 149,260,542 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E1 Start 61,932,463 bp [2] End 62,044,895 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right auricle of heart cardiac muscle tissue of right atrium glutes cerebellar hemisphere right hemisphere of cerebellum left ventricle paraflocculus of cerebellum subcutaneous adipose tissue right lobe of liver Top expressed in lumbar spinal ganglion right lung lobe interventricular septum supraoptic nucleus trigeminal ganglion otolith organ cerebellum cerebellar cortex utricle myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding actin binding protein binding Cellular component cytoplasm stress fiber lamellipodium Biological process cytoskeleton organization actin cytoskeleton organization transcription, DNA-templated lamellipodium assembly positive regulation of transcription by RNA polymerase II positive regulation of protein targeting to mitochondrion cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22885 319713 Ensembl ENSG00000173210 ENSMUSG00000032735 UniProt O94929 Q69ZX8 RefSeq (mRNA) NM_001301015 NM_001301018 NM_001301027 NM_001301028 NM_014945 NM_001345858 NM_001345859 NM_001345860 NM_001345861 NM_001370417 NM_001370418 NM_001164491 NM_198649 NM_001360868 RefSeq (protein) NP_001287944 NP_001287947 NP_001287957 NP_001332787 NP_001332788 NP_001332789 NP_001332790 NP_055760 NP_001357346 NP_001357347 NP_001157963 NP_941051 NP_001347797 Location (UCSC) Chr 5: 149.14 – 149.26 Mb Chr 18: 61.93 – 62.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene. ^[5]

Function

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer. ^[6] An important paralog of this gene is LIMS1.

Clinical relevance

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

References

1. GRCh38: Ensembl release 89: ENSG00000173210 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032735 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3".
6. Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID   16328021.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (Aug 2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID   15221005. S2CID   3114318.
• Zheng B, Wen JK, Han M, Zhou AR (Sep 2004). "hhLIM protein is involved in cardiac hypertrophy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1690 (1): 1–10. doi: 10.1016/j.bbadis.2004.04.009 . PMID   15337165.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)" . International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID   16328021.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N (Mar 2007). "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin". The Journal of Biological Chemistry. 282 (11): 8393–8403. doi: 10.1074/jbc.M607549200 . PMID   17194709.

External links

• Human ABLIM3 genome location and ABLIM3 gene details page in the UCSC Genome Browser .