ACBD3

ACBD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N72
Identifiers
Aliases	ACBD3 , GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3
External IDs	OMIM: 606809 MGI: 2181074 HomoloGene: 11227 GeneCards: ACBD3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	226,186,741 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,581,769 bp
RNA expression pattern
	Top expressed in
	tibia; ; amniotic fluid; ; endothelial cell; ; palpebral conjunctiva; ; secondary oocyte; ; germinal epithelium; ; visceral pleura; ; parietal pleura; ; cavity of mouth; ; Achilles tendon;
	Top expressed in
	secondary oocyte; ; medullary collecting duct; ; aortic valve; ; ascending aorta; ; left colon; ; urothelium; ; belly cord; ; parotid gland; ; calvaria; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase A regulatory subunit binding ; protein binding ; fatty-acyl-CoA binding ;
Cellular component	integral component of membrane ; Golgi apparatus ; membrane ; mitochondrion ; Golgi membrane ;
Biological process	steroid biosynthetic process ; lipid metabolism ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	64746
	170760
	ENSG00000182827
	ENSMUSG00000026499
	Q9H3P7
	Q8BMP6
	NM_022735
	NM_133225
	NP_073572 ; NP_073572.2
	NP_573488
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 25, 2024

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.^[5]

Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.^[6] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.^[5]

Interactions

ACBD3 has been shown to interact with GOLGB1.^[7]

Related Research Articles

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Golgin subfamily A member 2, also known as 130 kDa cis-Golgi matrix protein 1 (GM130) is a protein that in humans is encoded by the GOLGA2 gene.

Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.

Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.

BET1-like protein is a protein that in humans is encoded by the BET1L gene.

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.

Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.

Golgin A7 is a protein that in humans is encoded by the GOLGA7 gene. It is an acylated Golgi protein that interacts with GCP170 protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182827 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026499 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
↑ "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".
↑ Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi: 10.1074/jbc.M108961200 . PMID 11590181.

External links

Human ACBD3 genome location and ACBD3 gene details page in the UCSC Genome Browser .

Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi: 10.1074/jbc.M108961200 . PMID 11590181.
Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2002). "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein". Mol. Endocrinol. 15 (12): 2211–28. doi: 10.1210/mend.15.12.0736 . PMID 11731621. S2CID 27565320.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V (2003). "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues". FASEB J. 17 (9): 1189–91. doi: 10.1096/fj.02-1066fje . PMID 12692076. S2CID 19079882.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. doi: 10.1074/jbc.M603276200 . PMID 16870622.
Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. doi: 10.1074/jbc.M705794200 . PMID 17711851.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182827 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026499 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".

[6] "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".

[pmid11590181-7] Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi: 10.1074/jbc.M108961200 . PMID 11590181.

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