ACRV1

ACRV1
Identifiers
Aliases	ACRV1 , D11S4365, SP-10, SPACA2, acrosomal vesicle protein 1
External IDs	OMIM: 102525 MGI: 104590 HomoloGene: 1219 GeneCards: ACRV1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 125,671,522 bp [1] End 125,680,874 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A4|9 20.67 cM Start 36,604,516 bp [2] End 36,610,139 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm pancreatic ductal cell tibialis anterior muscle prefrontal cortex putamen caudate nucleus nucleus accumbens Brodmann area 9 ganglionic eminence cingulate gyrus Top expressed in spermatid seminiferous tubule spermatocyte seminal vesicula secondary oocyte medial ganglionic eminence islet of Langerhans hypothalamus temporal muscle Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 56 11451 Ensembl ENSG00000134940 ENSMUSG00000032110 UniProt P26436 P50289 RefSeq (mRNA) NM_020115 NM_001612 NM_020069 NM_020107 NM_020108 NM_020109 NM_020110 NM_020111 NM_020112 NM_020113 NM_020114 NM_007391 RefSeq (protein) NP_001603 NP_064454 NP_064492 NP_064493 NP_031417 Location (UCSC) Chr 11: 125.67 – 125.68 Mb Chr 9: 36.6 – 36.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene. ^{[5] [6] [7]}

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134940 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032110 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10". Biol Reprod. 42 (4): 693–701. doi: 10.1095/biolreprod42.4.693 . PMID   1693291.
6. Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9. doi:10.1006/geno.1993.1496. PMID   8288254.
7. "Entrez Gene: ACRV1 acrosomal vesicle protein 1".

External links

• Human ACRV1 genome location and ACRV1 gene details page in the UCSC Genome Browser .

Further reading

• Herr JC, Klotz K, Shannon J, et al. (1992). "Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes". Biol. Reprod. 47 (1): 11–20. doi: 10.1095/biolreprod47.1.11 . PMID   1637938.
• Homyk M, Anderson DJ, Wolff H, Herr JC (1990). "Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10". Fertil. Steril. 53 (2): 323–30. doi: 10.1016/s0015-0282(16)53289-0 . PMID   2298314.
• Freemerman AJ, Flickinger CJ, Herr JC (1995). "Characterization of alternatively spliced human SP-10 mRNAs". Mol. Reprod. Dev. 41 (1): 100–8. doi:10.1002/mrd.1080410115. PMID   7619499. S2CID   22411156.
• Foster JA, Klotz KL, Flickinger CJ, et al. (1995). "Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction". Biol. Reprod. 51 (6): 1222–31. doi: 10.1095/biolreprod51.6.1222 . PMID   7888499.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Wright RM, Suri AK, Kornreich B, et al. (1993). "Cloning and characterization of the gene coding for the human acrosomal protein SP-10". Biol. Reprod. 49 (2): 316–25. doi: 10.1095/biolreprod49.2.316 . PMID   8373955.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Reddi PP, Shore AN, Acharya KK, Herr JC (2002). "Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10". J. Reprod. Immunol. 53 (1–2): 25–36. doi:10.1016/S0165-0378(01)00104-8. PMID   11730901.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.