ACSBG1

ACSBG1
Identifiers
Aliases	ACSBG1 , BG, BG1, BGM, GR-LACS, LPD, acyl-CoA synthetase bubblegum family member 1
External IDs	OMIM: 614362 MGI: 2385656 HomoloGene: 9044 GeneCards: ACSBG1
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q25.1 Start 78,167,468 bp [1] End 78,245,688 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.3 Start 54,512,161 bp [2] End 54,569,154 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus endothelial cell internal globus pallidus putamen caudate nucleus substantia nigra nucleus accumbens external globus pallidus optic nerve amygdala Top expressed in lip cerebellar cortex adrenal gland visual cortex esophagus superior frontal gyrus medial vestibular nucleus cerebellar vermis dorsal tegmental nucleus inferior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity catalytic activity ATP binding decanoate-CoA ligase activity long-chain fatty acid-CoA ligase activity very long-chain fatty acid-CoA ligase activity Cellular component cytosol intracellular membrane-bounded organelle endoplasmic reticulum cytoplasmic vesicle cytoplasm Biological process lipid metabolism very long-chain fatty acid metabolic process response to glucocorticoid fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process myelination metabolism long-chain fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23205 94180 Ensembl ENSG00000103740 ENSMUSG00000032281 UniProt Q96GR2 Q99PU5 RefSeq (mRNA) NM_001199377 NM_015162 NM_053178 RefSeq (protein) NP_001186306 NP_055977 NP_444408 Location (UCSC) Chr 15: 78.17 – 78.25 Mb Chr 9: 54.51 – 54.57 Mb PubMed search [3] [4]
Wikidata
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Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene. ^{[5] [6] [7]}

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. ^[7] The conversion of long chain fatty acids into long chain acyl-CoAs in mice is catalysed by ACSBG1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000103740 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032281 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi: 10.1074/jbc.M006403200 . PMID   10954726.
7. "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".
8. Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID   11112418.

External links

• Human ACSBG1 genome location and ACSBG1 gene details page in the UCSC Genome Browser .

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Moriya-Sato A, Hida A, Inagawa-Ogashiwa M, et al. (2001). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem. Biophys. Res. Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID   11112418.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Pei Z, Oey NA, Zuidervaart MM, et al. (2004). "The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation." J. Biol. Chem. 278 (47): 47070–8. doi: 10.1074/jbc.M310075200 . PMID   12975357.
• Fraisl P, Forss-Petter S, Zigman M, Berger J (2004). "Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase". Biochem. J. 377 (Pt 1): 85–93. doi:10.1042/BJ20031062. PMC   1223850 . PMID   14516277.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Asheuer M, Bieche I, Laurendeau I, et al. (2005). "Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy". Hum. Mol. Genet. 14 (10): 1293–303. doi: 10.1093/hmg/ddi140 . PMID   15800013.