ACSM3

ACSM3
Identifiers
Aliases	ACSM3 , SA, SAH, acyl-CoA synthetase medium-chain family member 3, acyl-CoA synthetase medium chain family member 3
External IDs	OMIM: 145505 MGI: 99538 HomoloGene: 74559 GeneCards: ACSM3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,797,581 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	119,386,736 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; left uterine tube; ; body of pancreas; ; right uterine tube; ; kidney; ; body of stomach; ; rectum; ; gastric mucosa; ; canal of the cervix; ; right lung;
	Top expressed in
	left colon; ; proximal tubule; ; left lobe of liver; ; kidney; ; mucous cell of stomach; ; intercostal muscle; ; pyloric antrum; ; brown adipose tissue; ; epithelium of stomach; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; ligase activity ; catalytic activity ; ATP binding ; metal ion binding ; fatty-acyl-CoA synthase activity ; fatty acid ligase activity ; butyrate-CoA ligase activity ; molecular function ;
Cellular component	mitochondrion ; mitochondrial matrix ; cellular component ;
Biological process	regulation of blood pressure ; cholesterol homeostasis ; metabolism ; lipid metabolism ; fatty acid metabolic process ; fatty acid biosynthetic process ; acyl-CoA metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	6296
	20216
	ENSG00000005187
	ENSMUSG00000030935
	Q53FZ2
	Q3UNX5
	NM_005622 ; NM_202000
	NM_016870 ; NM_212441 ; NM_212442
	NP_005613 ; NP_973729
	NP_058566 ; NP_997606 ; NP_997607
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 23, 2023

Acyl-coenzyme A synthetase ACSM3, mitochondrial is an enzyme that in humans is encoded by the ACSM3 gene.^[5]^[6]^[7]^[8]

Related Research Articles

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Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene.

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.

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Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.

Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.

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SARS and cytoplasmic seryl-tRNA synthetase are a human gene and its encoded enzyme product, respectively. SARS belongs to the class II amino-acyl tRNA family and is found in all humans; its encoded enzyme, seryl-tRNA synthetase, is involved in protein translation and is related to several bacterial and yeast counterparts.

Ankyrin repeat and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ANKFY1 gene.

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Butyrophilin subfamily 3 member A3 is a protein that in humans is encoded by the BTN3A3 gene.

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene. This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.

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(See also: List of proteins in the human body)

Long-chain-fatty-acid—CoA ligase ACSBG2 is an enzyme that in humans is encoded by the ACSBG2 gene.

Acyl-CoA synthetase family member 3 is an enzyme that in humans is encoded by the ACSF3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000005187 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030935 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension. 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID 7843754.
↑ Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension. 23 (3): 375–80. doi: 10.1161/01.hyp.23.3.375 . PMID 7907320.
↑ Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry. 276 (38): 35961–6. doi: 10.1074/jbc.M106651200 . PMID 11470804.
↑ "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".

External links

Human ACSM3 genome location and ACSM3 gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Samani NJ, Whitmore SA, Kaiser MA, Harris J, See CG, Callen DF, Lodwick D (Mar 1994). "Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney". Biochemical and Biophysical Research Communications. 199 (2): 862–8. doi:10.1006/bbrc.1994.1308. PMID 8135833.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S (Jan 2002). "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension". Circulation. 105 (1): 41–7. doi: 10.1161/hc0102.101780 . PMID 11772874.
Narita I, Saito N, Goto S, Shirasaki A, Morioka Y, Jin S, Omori K, Sakatsume M, Arakawa M, Gejyo F (Nov 2002). "Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy". Hypertension Research. 25 (6): 831–6. doi: 10.1291/hypres.25.831 . PMID 12484505.
Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ (Aug 2003). "Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension". Hypertension Research. 26 (8): 591–5. doi: 10.1291/hypres.26.591 . PMID 14567496.
Telgmann R, Brand E, Nicaud V, Hagedorn C, Beining K, Schönfelder J, Brink-Spalink V, Schmidt-Petersen K, Matanis T, Vischer P, Nofer JR, Hasenkamp S, Plouin PF, Drouet L, Cambien F, Paul M, Tiret L, Brand-Herrmann SM (Mar 2007). "SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study". Journal of Hypertension. 25 (3): 557–64. doi:10.1097/HJH.0b013e3280144779. PMID 17278971. S2CID 39465138.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000005187 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030935 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7843754-5] Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension. 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID 7843754.

[pmid7907320-6] Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension. 23 (3): 375–80. doi: 10.1161/01.hyp.23.3.375 . PMID 7907320.

[pmid11470804-7] Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry. 276 (38): 35961–6. doi: 10.1074/jbc.M106651200 . PMID 11470804.

[entrez-8] "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".

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ACSM3

Contents

Related Research Articles

References

External links

Further reading