ACSM3

ACSM3
Identifiers
Aliases	ACSM3 , SA, SAH, acyl-CoA synthetase medium-chain family member 3, acyl-CoA synthetase medium chain family member 3
External IDs	OMIM: 145505; MGI: 99538; HomoloGene: 74559; GeneCards: ACSM3; OMA:ACSM3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.3 Start 20,610,243 bp [1] End 20,797,581 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F2 Start 119,360,146 bp [2] End 119,386,736 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary right lobe of liver left uterine tube body of pancreas right uterine tube mucosa of transverse colon body of uterus human kidney body of stomach Top expressed in right kidney left colon tunica adventitia of aorta proximal tubule left lobe of liver human kidney mucous cell of stomach intercostal muscle pyloric antrum brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity catalytic activity ATP binding metal ion binding fatty-acyl-CoA synthase activity fatty acid ligase activity butyrate-CoA ligase activity molecular function Cellular component mitochondrion mitochondrial matrix cellular component Biological process regulation of blood pressure cholesterol homeostasis metabolism lipid metabolism fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6296 20216 Ensembl ENSG00000005187 ENSMUSG00000030935 UniProt Q53FZ2 Q3UNX5 RefSeq (mRNA) NM_005622 NM_202000 NM_016870 NM_212441 NM_212442 RefSeq (protein) NP_005613 NP_973729 NP_058566 NP_997606 NP_997607 Location (UCSC) Chr 16: 20.61 – 20.8 Mb Chr 7: 119.36 – 119.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acyl-CoA synthetase medium-chain family member 3 (ACSM3) is a mitochondrial enzyme that in humans is encoded by the ACSM3 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000005187 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030935 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension. 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID   7843754.
6. Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension. 23 (3): 375–80. doi: 10.1161/01.hyp.23.3.375 . PMID   7907320.
7. Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry. 276 (38): 35961–6. doi: 10.1074/jbc.M106651200 . PMID   11470804.
8. "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".

External links

• Human ACSM3 genome location and ACSM3 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Samani NJ, Whitmore SA, Kaiser MA, Harris J, See CG, Callen DF, Lodwick D (Mar 1994). "Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney". Biochemical and Biophysical Research Communications. 199 (2): 862–8. doi:10.1006/bbrc.1994.1308. PMID   8135833.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID   10493829.
• Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S (Jan 2002). "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension". Circulation. 105 (1): 41–7. doi: 10.1161/hc0102.101780 . PMID   11772874.
• Narita I, Saito N, Goto S, Shirasaki A, Morioka Y, Jin S, Omori K, Sakatsume M, Arakawa M, Gejyo F (Nov 2002). "Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy". Hypertension Research. 25 (6): 831–6. doi: 10.1291/hypres.25.831 . PMID   12484505.
• Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ (Aug 2003). "Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension". Hypertension Research. 26 (8): 591–5. doi: 10.1291/hypres.26.591 . PMID   14567496.
• Telgmann R, Brand E, Nicaud V, Hagedorn C, Beining K, Schönfelder J, Brink-Spalink V, Schmidt-Petersen K, Matanis T, Vischer P, Nofer JR, Hasenkamp S, Plouin PF, Drouet L, Cambien F, Paul M, Tiret L, Brand-Herrmann SM (Mar 2007). "SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study". Journal of Hypertension. 25 (3): 557–64. doi:10.1097/HJH.0b013e3280144779. PMID   17278971. S2CID   39465138.