ADAMTSL1

Last updated
ADAMTSL1
Identifiers
Aliases ADAMTSL1 , ADAMTSL-1, ADAMTSR1, C9orf94, PUNCTIN, ADAMTS like 1
External IDs OMIM: 609198 MGI: 1924989 HomoloGene: 64642 GeneCards: ADAMTSL1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040272
NM_052866
NM_139238
NM_139264

NM_029967
NM_172542
NM_001368621

RefSeq (protein)

NP_001035362
NP_443098

NP_084243
NP_001355550

Location (UCSC) Chr 9: 17.91 – 18.91 Mb Chr 4: 85.43 – 86.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADAMTS-like protein 1 is a protein that in humans is encoded by the ADAMTSL1 gene. [5] [6] [7]

Contents

This gene encodes a secreted protein resembling members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the propeptide region and the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [7]

Related Research Articles

<span class="mw-page-title-main">ADAMTS2</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase is an enzyme that in humans is encoded by the ADAMTS2 gene.

<span class="mw-page-title-main">ADAMTS4</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.

<span class="mw-page-title-main">ADAM15</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene.

<span class="mw-page-title-main">ADAMTS1</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

<span class="mw-page-title-main">ADAM9</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

<span class="mw-page-title-main">MMP16</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.

<span class="mw-page-title-main">ADAMTSL4</span> Protein-coding gene in the species Homo sapiens

ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.

ADAMTS is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13.

<span class="mw-page-title-main">ADAMTS8</span>

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.

<span class="mw-page-title-main">ADAMTS9</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.

<span class="mw-page-title-main">ADAMTS10</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.

<span class="mw-page-title-main">MMP23B</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23B gene.

<span class="mw-page-title-main">ADAM11</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.

<span class="mw-page-title-main">ADAMTS3</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene. The protein encoded by this gene is the major procollagen II N-propeptidase.

<span class="mw-page-title-main">CHSY1</span>

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.

<span class="mw-page-title-main">THSD1</span>

Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene.

<span class="mw-page-title-main">ADAMTS12</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.

<span class="mw-page-title-main">ADAM18</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.

<span class="mw-page-title-main">PAPLN</span>

Papilin is a protein that in humans is encoded by the PAPLN gene. Papilin is an extracellular matrix glycoprotein.

<span class="mw-page-title-main">ADAMTS17</span>

ADAM metallopeptidase with thrombospondin type 1 motif, 17 is a protein that in humans is encoded by the ADAMTS17 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000178031 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066113 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
  6. Hirohata S, Wang LW, Miyagi M, Yan L, Seldin MF, Keene DR, Crabb JW, Apte SS (Apr 2002). "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix". J Biol Chem. 277 (14): 12182–9. doi: 10.1074/jbc.M109665200 . PMID   11805097.
  7. 1 2 "Entrez Gene: ADAMTSL1 ADAMTS-like 1".

Further reading