AHSA1

AHSA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X53
Identifiers
Aliases	AHSA1 , AHA1, C14orf3, p38, hAha1, activator of Hsp90 ATPase activity 1
External IDs	OMIM: 608466; MGI: 2387603; HomoloGene: 8106; GeneCards: AHSA1; OMA:AHSA1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.3 Start 77,457,870 bp [1] End 77,469,472 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 D2 Start 87,313,253 bp [2] End 87,320,772 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte right testis secondary oocyte left testis right uterine tube ventricular zone ganglionic eminence muscle of thigh C1 segment Brodmann area 9 Top expressed in otic vesicle saccule otic placode zygote epiblast mandibular prominence embryo maxillary prominence fetal liver hematopoietic progenitor cell dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activator activity chaperone binding protein binding cadherin binding Hsp90 protein binding Cellular component extracellular exosome endoplasmic reticulum cytoplasm cytosol Biological process response to stress positive regulation of ATP-dependent activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10598 217737 Ensembl ENSG00000100591 ENSMUSG00000021037 UniProt O95433 Q8BK64 RefSeq (mRNA) NM_012111 NM_001321441 NM_146036 RefSeq (protein) NP_001308370 NP_036243 NP_666148 Location (UCSC) Chr 14: 77.46 – 77.47 Mb Chr 12: 87.31 – 87.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Activator of 90 kDa heat shock protein ATPase homolog 1 is an enzyme that in humans is encoded by the AHSA1 gene. ^[5]

Interactions

AHSA1 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000100591 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021037 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)".
6. Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C (Dec 2002). "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1" (PDF). Mol. Cell. 10 (6): 1307–18. doi:10.1016/S1097-2765(02)00785-2. PMID   12504007.

External links

• Human AHSA1 genome location and AHSA1 gene details page in the UCSC Genome Browser .

Further reading

• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Sevier CS, Machamer CE (2001). "p38: A novel protein that associates with the vesicular stomatitis virus glycoprotein". Biochem. Biophys. Res. Commun. 287 (2): 574–82. doi:10.1006/bbrc.2001.5621. PMID   11554768.
• Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C (2002). "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1" (PDF). Mol. Cell. 10 (6): 1307–18. doi:10.1016/S1097-2765(02)00785-2. PMID   12504007.
• Lotz GP, Lin H, Harst A, Obermann WM (2003). "Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone". J. Biol. Chem. 278 (19): 17228–35. doi: 10.1074/jbc.M212761200 . PMID   12604615.
• Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j.1471-4159.2006.03836.x. PMC   2239266 . PMID   16696853.
• Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE (2006). "Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis". Cell. 127 (4): 803–15. doi: 10.1016/j.cell.2006.09.043 . PMID   17110338. S2CID   1457851.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.