AKAP7

AKAP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZP3
Identifiers
Aliases	AKAP7 , AKAP15, AKAP18, A-kinase anchoring protein 7
External IDs	OMIM: 604693; MGI: 1859150; HomoloGene: 49463; GeneCards: AKAP7; OMA:AKAP7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 131,135,467 bp [1] End 131,283,535 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A4 Start 25,044,988 bp [2] End 25,183,768 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left adrenal gland right adrenal gland left adrenal cortex right adrenal cortex duodenum mucosa of sigmoid colon pancreatic epithelial cell biceps brachii endothelial cell Top expressed in zygote lobe of cerebellum cerebellar vermis secondary oocyte neural layer of retina jejunum duodenum primary motor cortex primary oocyte epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase A binding protein binding nucleotide binding protein kinase binding protein kinase A regulatory subunit binding Cellular component plasma membrane apical plasma membrane lateral plasma membrane membrane intracellular anatomical structure cytoplasm cytosol nucleus protein-containing complex hippocampal mossy fiber to CA3 synapse Biological process action potential protein localization regulation of membrane repolarization intracellular signal transduction ion transport cellular response to cAMP positive regulation of delayed rectifier potassium channel activity positive regulation of potassium ion transmembrane transport regulation of protein kinase A signaling biological process modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9465 432442 Ensembl ENSG00000118507 ENSMUSG00000039166 UniProt O43687 Q9P0M2 O55074 Q7TN79 RefSeq (mRNA) NM_004842 NM_016377 NM_138633 NM_001376570 NM_001387860 NM_001387861 NM_001387862 NM_001387863 NM_001387864 NM_018747 NM_001347460 NM_001379238 NM_001379239 NM_001379240 RefSeq (protein) NP_004833 NP_057461 NP_619539 NP_001363499 NP_057461.2 NP_001334389 NP_061217 NP_001366167 NP_001366168 NP_001366169 NP_061217.3 Location (UCSC) Chr 6: 131.14 – 131.28 Mb Chr 10: 25.04 – 25.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene. ^{[5] [6]}

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000118507 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039166 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC   1170570 . PMID   9545239.
6. "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

External links

• Human AKAP7 genome location and AKAP7 gene details page in the UCSC Genome Browser .

Further reading

• Gold MG, Smith FD, Scott JD, Barford D (Feb 2008). "AKAP18 contains a phosphoesterase domain that binds AMP". Journal of Molecular Biology. 375 (5): 1329–1343. doi:10.1016/j.jmb.2007.11.037. PMC   3188456 . PMID   18082768.
• Bengrine A, Li J, Awayda MS (Apr 2007). "The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel". FASEB Journal. 21 (4): 1189–1201. doi: 10.1096/fj.06-6046com . PMID   17244820. S2CID   34457423.
• Brown RL, August SL, Williams CJ, Moss SB (Jun 2003). "AKAP7gamma is a nuclear RI-binding AKAP". Biochemical and Biophysical Research Communications. 306 (2): 394–401. doi:10.1016/S0006-291X(03)00982-3. PMID   12804576.
• Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4445–4450. Bibcode:2003PNAS..100.4445A. doi: 10.1073/pnas.0330734100 . PMC   153575 . PMID   12672969.
• Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL (Dec 1999). "Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms". The Journal of Cell Biology. 147 (7): 1481–1492. doi:10.1083/jcb.147.7.1481. PMC   2174236 . PMID   10613906.