ALS2CR8

CARF
Identifiers
Aliases	CARF , ALS2CR8, NYD-SP24, calcium responsive transcription factor
External IDs	OMIM: 607586 MGI: 2182269 HomoloGene: 11689 GeneCards: CARF
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q33.2 Start 202,912,214 bp [1] End 202,988,263 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C2 Start 60,098,247 bp [2] End 60,153,953 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right uterine tube sural nerve gallbladder ganglionic eminence popliteal artery islet of Langerhans rectum left lobe of thyroid gland corpus callosum Top expressed in spermatocyte pineal gland spermatid seminiferous tubule medullary collecting duct superior frontal gyrus olfactory tubercle nucleus accumbens vas deferens Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleolus nucleoplasm nucleus Biological process cellular response to calcium ion positive regulation of transcription from RNA polymerase II promoter in response to calcium ion regulation of transcription, DNA-templated transcription, DNA-templated cellular response to potassium ion positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79800 241066 Ensembl ENSG00000138380 ENSMUSG00000026017 UniProt Q8N187 Q8VHI4 RefSeq (mRNA) NM_001104586 NM_001282910 NM_001282911 NM_001282912 NM_024744 NM_001322427 NM_001322428 NM_001322429 NM_001322430 NM_001352676 NM_001352677 NM_001352678 NM_001352679 NM_001285463 NM_001285473 NM_139150 RefSeq (protein) NP_001098056 NP_001269839 NP_001269840 NP_001269841 NP_001309356 NP_001309357 NP_001309358 NP_079020 NP_001339605 NP_001339606 NP_001339607 NP_001339608 NP_001272392 NP_001272402 NP_631889 Location (UCSC) Chr 2: 202.91 – 202.99 Mb Chr 1: 60.1 – 60.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene. ^{[5] [6]}

Knocking out the Carf (Als2cr8) gene in mice results in learning associated deficits. Furthermore, Carf has been shown to function as a transcription factor that regulates the expression of BDNF. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138380 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026017 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID   11586298. S2CID   52828189.
6. "Entrez Gene: ALS2CR8 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8".
7. Tao X, West AE, Chen WG, Corfas G, Greenberg ME (January 2002). "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF". Neuron. 33 (3): 383–95. doi: 10.1016/S0896-6273(01)00561-X . PMID   11832226. S2CID   10874584.

External links

• Human CARF genome location and CARF gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Tao X, West AE, Chen WG, et al. (2002). "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF". Neuron. 33 (3): 383–95. doi: 10.1016/S0896-6273(01)00561-X . PMID   11832226. S2CID   10874584.
• Hasan MK, Yaguchi T, Sugihara T, et al. (2002). "CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53". J. Biol. Chem. 277 (40): 37765–70. doi: 10.1074/jbc.M204177200 . PMID   12154087.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.