The New Reform Party of Ontario was a minor provincial political party in Ontario, Canada, that promoted a populist, fiscally conservative, socially conservative, libertarian, and localist ideology.
Muscular Dystrophy Canada (MDC) is a non-profit organization that strives to find a cure for neuromuscular disorders. Founded in 1954 as Muscular Dystrophy Association of Canada, volunteers and staff nationwide have helped to provide support and resources to those affected. Since the founding year, over $64 million has been put towards research via collaborations, fundraising events, and donations.
Primary lateral sclerosis (PLS) is a very rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. PLS belongs to a group of disorders known as motor neuron diseases. Motor neuron diseases develop when the nerve cells that control voluntary muscle movement degenerate and die, causing weakness in the muscles they control.
Progressive muscular atrophy (PMA), also called Duchenne–Aran disease and Duchenne–Aran muscular atrophy, is a disorder characterised by the degeneration of lower motor neurons, resulting in generalised, progressive loss of muscle function.
Progressive bulbar palsy (PBP) is a medical condition. It belongs to a group of disorders known as motor neuron diseases. PBP is a disease that attacks the nerves supplying the bulbar muscles. These disorders are characterized by the degeneration of motor neurons in the cerebral cortex, spinal cord, brain stem, and pyramidal tracts. This specifically involves the glossopharyngeal nerve (IX), vagus nerve (X), and hypoglossal nerve (XII).
Jo-Anna Downey was a multiple Canadian Comedy Award-nominated stand-up comedian.
Mark Robert Kirton is a Canadian former professional ice hockey player who played 266 games in the National Hockey League. He played for the Toronto Maple Leafs, Detroit Red Wings, and Vancouver Canucks. He also spent several years in the American Hockey League playing for the minor league affiliates of the NHL teams.
Eva Lucille Feldman, M.D., Ph.D., F.A.A.N., F.A.N.A. is an American physician-scientist and one of the world’s leading authorities on neurodegenerative disease. Currently, she serves as the Russell N. DeJong Professor of Neurology at the University of Michigan, as well as Director of the NeuroNetwork for Emerging Therapies and ALS Center of Excellence at Michigan Medicine.
The ALS Association is an American nonprofit organization that funds global amyotrophic lateral sclerosis (ALS) research, provides care services and programs to people affected by ALS through its nationwide network of chapters, and works with ALS advocates around the country for state and federal policies that serve people living with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The ALS Association is broken up into distinct chapters, each servicing a particular geographic area of the United States and all working under the umbrella of a national charter and administrator.
Prize4Life is a non-profit organization dedicated to the discovery of treatments and a cure for amyotrophic lateral sclerosis (ALS). The organization uses the inducement prize contest model. It was founded in 2007 by Avi Kremer, an Israeli student at Harvard Business School, who was diagnosed with ALS at the age of 29.
Augustine L. "Augie" Nieto II is the founder and retired chief executive of Life Fitness, as well as the current chairman of Augie's Quest to Cure ALS, and the ALS Therapy Development Institute. He and his wife, Lynne, live in Corona Del Mar, California, and have four children and eight grandchildren.
Orla Hardiman is an Irish consultant neurologist. She was appointed Professor of Neurology by Trinity College University of Dublin in 2014, where she heads the Academic Unit of Neurology, housed in Trinity Biomedical Sciences Institute. She is a HRB Clinician Scientist and Consultant Neurologist at the National Neuroscience Center of Ireland at Beaumont Hospital, Dublin. She leads a team of 30 researchers focussing on clinical and translational aspects of amyotrophic lateral sclerosis and related neurodegenerations. Hardiman has become a prominent advocate for neurological patients in Ireland, and for patients within the Irish health system generally. She is co-Founder of the Neurological Alliance of Ireland, and Doctors Alliance for Better Public Healthcare. In the past, she established the bi-annual Diaspora Meeting, a forum for Irish neurologists based overseas to present and discuss their research findings with neurologists working in Ireland.
Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most common type of motor neuron disease. Early symptoms of ALS include stiff muscles, muscle twitches, and gradual increasing weakness and muscle wasting. Limb-onset ALS begins with weakness in the arms or legs, while bulbar-onset ALS begins with difficulty speaking or swallowing. Half of the people with ALS develop at least mild difficulties with thinking and behavior, and about 15% develop frontotemporal dementia. Most people experience pain. The affected muscles are responsible for chewing food, speaking, and walking. Motor neuron loss continues until the ability to eat, speak, move, and finally the ability to breathe is lost. ALS eventually causes paralysis and early death, usually from respiratory failure.
The Brain Research Foundation (BRF) is a non-profit private organization in Chicago, Illinois. The foundation was established in 1953 to promote and support scientific research concerning the brain. The BRF aides scientists in their pursuits to understand, prevent, treat, and cure brain disorders. Brain tumors, multiple sclerosis, Alzheimer's and Parkinson's diseases, epilepsy, amyotrophic lateral sclerosis (ALS), learning disorders, depression and many others are disorders the BRF has helped raise awareness for.
The Canadian Spinal Research Organization (SCRO) is a nationally registered charity whose mission is to improve the physical quality of life for persons with spinal cord injuries (SCI) and related neurological deficits, as well as to reduce the number of spinal cord injuries through awareness and prevention programs.
ALS Awareness Month is a campaign to spread awareness of and raise funds for research for a cure for ALS.
The Les Turner ALS Foundation is a non-profit organization based in Chicago that provides amyotrophic lateral sclerosis (ALS) patient services; supports events, education and awareness about ALS; and funds ALS research. Since it was founded, it has raised over $64 million.
There are more than 25 genes known to be associated with amyotrophic lateral sclerosis (ALS) as of June 2018, which collectively account for about 70% of cases of familial ALS (fALS) and 10% of cases of sporadic ALS (sALS). About 5–10% of cases of ALS are directly inherited from a person's parents. Overall, first-degree relatives of an individual with ALS have a 1% risk of developing ALS. ALS has an oligogenic mode of inheritance, meaning that mutations in two or more genes are required to cause disease.
Research on amyotrophic lateral sclerosis has focused on animal models of the disease, its mechanisms, ways to diagnose and track it, and treatments.
Merit Cudkowicz is an American neurologist, neuroscientist, and studies amyotrophic lateral sclerosis (ALS). Cudkowicz is Julieanne Dorn Professor of Neurology at Harvard Medical School, director of the ALS clinic and the Neurological Clinical Research Institute at Massachusetts General Hospital (MGH) and chair of the Department of Neurology at MGH. Cudkowicz has led several large scale collaborations and clinical trials to test novel treatments for ALS and as of 2020 researches ways to detect early biomarkers of ALS to improve diagnosis.
