Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene. [5] [6]
Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells. [6]
AMFR has been shown to interact with Valosin-containing protein. [7] [8]