| ANKRD26 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ANKRD26 , THC2, bA145E8.1, ankyrin repeat domain 26, ankyrin repeat domain containing 26 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610855 MGI: 1917887 HomoloGene: 45968 GeneCards: ANKRD26 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene. [5] [6] This protein has a function that is not currently understood.
Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene. [7]
ANKRD26 is found on chromosome 10, at 10q21. It has 6816 base pairs in the reference sequence mRNA transcript. [8]
LOC100289548 (PUTAETIVE UNCHARACTERIZED PROTEIN C10ORF52-LIKE) is located directly to the left (3') of ANKRD26, and is a protein coding gene located at 10p12.1. [9] It has an unknown function. On the other side of LOC100289548 is NCRNA00202 non-protein coding RNA 202. [10] On the 5' end of ANKRD26, YME1L1 can be found at 10q14.1. The protein encoded by the YME1-like 1 is an ortholog of yeast mitochondrial AAAmetalloprotease. [11] This gene is thought to play a role in mitochondrial protein metabolism. [11] On the positive strand of human chromosome ten, located next to the 5' end of ANKRD26 is MASTL, microtubule associated serine/threonine kinase-like. This particular gene encodes the microtubule associated serine/threonine kinase.1 Mutations within these gene have been expected to be associated with thrombocytopenia-2. [12]
[13] Ankyrin repeat domain-containing protein 26 has three conserved domains: ANK, SbcC, and DUF3496. ANK conserved domain is located from amino acid 74–199. Ankyrin repeats are found to mediate protein-protein interactions, and also contains two antiparallel helices, as well as a beta-hairpin. SbcC conserved domain can be found from amino acid 743–1333, and is domain associated with ATPase involved in DNA repair. There is also a domain of unknown function from amino acid 1538–1649.
In humans ANKRD26 was seen to be most highly expressed in the ear, lymph, esophagus, parathyroid, and placenta, as well as, most commonly seen in esophageal tumors and lymphoma, as well as seen in the blastocyst, fetus, juvenile, and adult developmental stages. In humans this is associated at all stages of life with lymphoma cancer as well as esophageal tumors. The association with expression in tissues and disease states doesn't show enough difference to link one another. [14]
GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.
Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.
Serine/threonine-protein kinase, Intestinal cell kinase or ICK is an enzyme that in humans is encoded by the ICK gene.
KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene.
Ankyrin repeat domain-containing protein 17 is a protein that in humans is encoded by the ANKRD17 gene.
Cysteine and tyrosine-rich protein 1 is a protein that in humans is encoded by the CYYR1 gene and is located on chromosome 21, location 21q21.2. This protein has a function that is not presently understood.
KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.
Ankyrin repeat domain-containing protein 13C is a protein that in humans is encoded by the ANKRD13C gene.
Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.
Transmembrane protein 98 is a single-pass membrane protein that in humans is encoded by the TMEM98 gene. The function of this protein is currently unknown. TMEM98 is also known as UNQ536/PRO1079.
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 is a protein that in humans is encoded by the ASZ1 gene.
TSR3, or TSR3 Ribosome Maturation Factor, is a hypothetical human protein found on chromosome 16. Its protein is 312 amino acids long and its cDNA has 1214 base pairs. It was previously designated C16orf42.
Tetratricopeptide repeat 39A is a human protein encoded by the TTC39A gene. TTC39A is also known as DEME-6, KIAA0452, and c1orf34. The function of TTC39A is currently not well understood. The main feature within tetratricopeptide repeat 39A is the domain of unknown function 3808 (DUF3808), spanning almost the entire protein. KIAA0452 can also be seen as an isoform of TTC39A because of differences in genome sequence, but overlap in DUF domain.
POTE ankyrin domain family, member B is a protein in humans that is encoded by the POTEB gene.(Prostate, Ovary, Testes Expressed ankyrin domain family member B).It is most likely involved in mediating protein-protein interaction via its 5 ankyrin domains. POTEB is most probably aids in intracellular signaling, but is not likely to be a secreted or nuclear protein. POTEB's function is likely to be regulated via 17 potential phosphorylation sites. There is currently no evidence to suggest that POTEB has nuclear localization signals.
Coiled coil domain containing protein 120 (CCDC120), also known as JM11 protein, is a protein that, in humans, is encoded by the CCDC120 gene. The function of CCDC120 has not been formally identified but structural components, conservation, and interactions can be identified computationally.
Family with Sequence Similarity 203, Member B (FAM203B) is a protein encoded by the FAM203B gene (8q24.3) in humans. While FAM203B is only found in humans and possibly non-human primates, its paralog, FAM203A, is highly conserved. The FAM203B protein contains two conserved domains of unknown function, DUF383 and DUF384, and no transmembrane domains. This protein has no known function yet, although the homolog of FAM203A in Caenorhabditis elegans (Y54H5A.2) is thought to help regulate the actin cytoskeleton.
Ankyrin repeat domain-containing protein 24 is a protein in humans that is coded for by the ANKRD24 gene. The gene is also known as KIAA1981. The protein's function in humans is currently unknown. ANKRD24 is in the protein family that contains ankyrin-repeat domains.
Transmembrane protein 255A is a protein that is encoded by the TMEM255A gene. TMEM255A is often referred to as family with sequence similarity 70, member A (FAM70A). The TMEM255A protein is transmembrane and is predicted to be located the nuclear envelope of eukaryote organisms.
WD Repeat and Coiled-coiled containing protein (WDCP) is a protein which in humans is encoded by the WDCP gene. The function of the protein is not completely understood, but WDCP has been identified in a fusion protein with anaplastic lymphoma kinase found in colorectal cancer. WDCP has also been identified in the MRN complex, which processes double-stranded breaks in DNA.
CAP-Gly Domain Containing Linker Protein Family Member 4 is a protein that in humans is encoded by the CLIP4 gene. In terms of conserved domains, the CLIP4 gene contains primarily ankyrin repeats and the eponymous CAP-Gly domains. The structure of the CLIP4 protein is largely made up of coil, with alpha helices dominating the rest of the protein. CLIP4 mRNA expression occurs largely in the adrenal cortex and atrioventricular node. The literature encompassing CLIP4's conserved domains and paralogs points toward microtubule regulation as a possible function of CLIP4.
 | This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it. |
