ANKS1B

ANKS1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EAM, 2KE7, 2KIV, 2M38
Identifiers
Aliases	ANKS1B , AIDA, AIDA-1, ANKS2, EB-1, EB1, cajalin-2, ankyrin repeat and sterile alpha motif domain containing 1B
External IDs	OMIM: 607815; MGI: 1924781; HomoloGene: 51570; GeneCards: ANKS1B; OMA:ANKS1B - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse) [1] Band 10|10 C2 Start 89,873,509 bp [1] End 90,973,300 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in olfactory tubercle medial dorsal nucleus piriform cortex superior frontal gyrus nucleus accumbens lateral septal nucleus medial geniculate nucleus dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord lobe of cerebellum BioGPS More reference expression data
Gene ontology Molecular function ephrin receptor binding Cellular component cytoplasm cell junction Cajal body postsynaptic membrane dendritic spine cell projection synapse membrane postsynaptic density nucleus cytosol plasma membrane intracellular membrane-bounded organelle Biological process regulation of synaptic plasticity by receptor localization to synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56899 77531 Ensembl ENSG00000185046 ENSMUSG00000058589 UniProt Q7Z6G8 Q8BIZ1 RefSeq (mRNA) NM_001204065 NM_001204066 NM_001204067 NM_001204068 NM_001204069 NM_001204070 NM_001204079 NM_001204080 NM_001204081 NM_020140 NM_152788 NM_181670 NM_001128086 NM_001177396 NM_001177397 NM_001177398 NM_181398 NM_001347053 NM_001347054 NM_001359240 NM_001359241 NM_001359242 RefSeq (protein) NP_001190994 NP_001190995 NP_001190996 NP_001190997 NP_001190998 NP_001190999 NP_001191008 NP_001191009 NP_001191010 NP_064525 NP_690001 NP_858056 NP_001339114 NP_001339115 NP_001339116 NP_001339117 NP_001339118 NP_001339119 NP_001339120 NP_001339121 NP_001339122 NP_001339123 NP_001339124 NP_001339125 NP_001339126 NP_001339127 NP_001339128 NP_001339129 NP_001339130 NP_001339131 NP_001339132 NP_001339133 NP_001339134 NP_001339135 NP_001339136 NP_001339137 NP_001339138 NP_001339139 NP_001339140 NP_001339141 NP_001339142 NP_001339143 NP_001339145 NP_001339146 NP_001339147 NP_001339148 NP_001339149 NP_001339150 NP_001339151 NP_001339152 NP_001339153 NP_001339154 NP_001121558 NP_001170867 NP_001170868 NP_001170869 NP_001333982 NP_001333983 NP_852063 NP_001346169 NP_001346170 NP_001346171 Location (UCSC) n/a Chr 10: 89.87 – 90.97 Mb PubMed search [2] [3]
Wikidata
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Ankyrin repeat and sterile alpha motif domain-containing protein 1B is a protein that in humans is encoded by the ANKS1B gene. ^{[4] [5] [6]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000058589 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Fu X, McGrath S, Pasillas M, Nakazawa S, Kamps MP (Oct 1999). "EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1". Oncogene. 18 (35): 4920–9. doi: 10.1038/sj.onc.1202874 . PMID   10490826.
5. Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR (Nov 2002). "Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia". Proc Natl Acad Sci U S A. 99 (23): 15101–6. Bibcode:2002PNAS...9915101W. doi: 10.1073/pnas.222481199 . PMC   137550 . PMID   12415113.
6. "Entrez Gene: ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B".

External links

• Human AIDA genome location and AIDA gene details page in the UCSC Genome Browser .
• Human ANKS1B genome location and ANKS1B gene details page in the UCSC Genome Browser .

Further reading

• LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia". Front. Biosci. 8 (1–3): s206–22. doi: 10.2741/1030 . PMID   12700034.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi: 10.1242/jcs.00243 . PMID   12508107.
• Liu F, Su Y, Li B, Ni B (2003). "Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751". Exp. Cell Res. 287 (2): 387–96. doi:10.1016/S0014-4827(03)00152-6. PMID   12837293.
• Ghersi E, Vito P, Lopez P, et al. (2004). "The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing". J. Alzheimers Dis. 6 (1): 67–78. doi:10.3233/JAD-2004-6108. PMID   15004329.
• Ghersi E, Noviello C, D'Adamio L (2005). "Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner". J. Biol. Chem. 279 (47): 49105–12. doi: 10.1074/jbc.M405329200 . PMID   15347684.
• Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 (1): 23. doi: 10.1186/1471-2121-6-23 . PMC   1097723 . PMID   15862129.
• Meleshko AN, Belevtsev MV, Savitskaja TV, Potapnev MP (2007). "The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression". Leuk. Res. 30 (7): 795–800. doi:10.1016/j.leukres.2005.11.007. PMID   16386788.