ANTXR1

ANTXR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N2N
Identifiers
Aliases	ANTXR1 , ATR, GAPO, TEM8, anthrax toxin receptor 1, ANTXR cell adhesion molecule 1
External IDs	OMIM: 606410 MGI: 1916788 HomoloGene: 12976 GeneCards: ANTXR1
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.3 Start 69,013,176 bp [1] End 69,249,327 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 87,110,835 bp [2] End 87,312,803 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium palpebral conjunctiva saphenous vein vena cava right coronary artery synovial joint pericardium urethra thoracic aorta ascending aorta Top expressed in median eminence body of femur cornea condyle molar belly cord fossa internal carotid artery ciliary body calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding protein binding collagen binding transmembrane signaling receptor activity metal ion binding signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane cell projection endosome membrane lamellipodium membrane extracellular exosome membrane filopodium membrane external side of plasma membrane Biological process actin cytoskeleton reorganization reproductive process substrate adhesion-dependent cell spreading signal transduction positive regulation of metallopeptidase activity negative regulation of extracellular matrix assembly blood vessel development toxin transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84168 69538 Ensembl ENSG00000169604 ENSMUSG00000033420 UniProt Q9H6X2 Q96EC6 Q9CZ52 RefSeq (mRNA) NM_018153 NM_032208 NM_053034 NM_054041 RefSeq (protein) NP_060623 NP_115584 NP_444262 NP_060623.2 NP_473382 Location (UCSC) Chr 2: 69.01 – 69.25 Mb Chr 6: 87.11 – 87.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene. ^{[5] [6] [7]} Its molecular weight is predicted as about 63kDa.

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described. ^[7]

See also

• Anthrax toxin

References

1. GRCh38: Ensembl release 89: ENSG00000169604 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033420 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. doi:10.1126/science.289.5482.1197. PMID   10947988.
6. Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (Sep 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res. 61 (18): 6649–55. PMID   11559528.
7. "Entrez Gene: ANTXR1 anthrax toxin receptor 1".

External links

• Human ANTXR1 genome location and ANTXR1 gene details page in the UCSC Genome Browser .
• Human ATR genome location and ATR gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Schmidt DR, Schreiber SL (1999). "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry. 38 (44): 14711–7. CiteSeerX   10.1.1.559.7745 . doi:10.1021/bi991614n. PMID   10545197.
• Liu XH, Collier RJ, Youle RJ (2002). "Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein". J. Biol. Chem. 276 (49): 46326–32. doi: 10.1074/jbc.M108930200 . PMID   11574549.
• Bradley KA, Mogridge J, Mourez M, et al. (2001). "Identification of the cellular receptor for anthrax toxin". Nature. 414 (6860): 225–9. doi:10.1038/n35101999. PMID   11700562. S2CID   4373278.
• Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene. 20 (46): 6784–93. doi: 10.1038/sj.onc.1204883 . PMID   11709713.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scobie HM, Rainey GJ, Bradley KA, Young JA (2003). "Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5170–4. Bibcode:2003PNAS..100.5170S. doi: 10.1073/pnas.0431098100 . PMC   154317 . PMID   12700348.
• Bradley KA, Mogridge J, Jonah G, et al. (2004). "Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions". J. Biol. Chem. 278 (49): 49342–7. doi: 10.1074/jbc.M307900200 . PMID   14507921.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Jones GG, Reaper PM, Pettitt AR, Sherrington PD (2004). "The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes". Oncogene. 23 (10): 1911–21. doi: 10.1038/sj.onc.1207318 . PMID   14755251. S2CID   31825072.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC   395752 . PMID   14759258.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bonuccelli G, Sotgia F, Frank PG, et al. (2005). "ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection". Am. J. Physiol., Cell Physiol. 288 (6): C1402–10. doi:10.1152/ajpcell.00582.2004. PMID   15689409.
• Hotchkiss KA, Basile CM, Spring SC, et al. (2005). "TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen". Exp. Cell Res. 305 (1): 133–44. doi:10.1016/j.yexcr.2004.12.025. PMID   15777794.
• Rmali KA, Puntis MC, Jiang WG (2005). "TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains". Biochem. Biophys. Res. Commun. 334 (1): 231–8. doi:10.1016/j.bbrc.2005.06.085. PMID   15993844.
• Rainey GJ, Wigelsworth DJ, Ryan PL, et al. (2005). "Receptor-specific requirements for anthrax toxin delivery into cells". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13278–83. Bibcode:2005PNAS..10213278R. doi: 10.1073/pnas.0505865102 . PMC   1201603 . PMID   16141341.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.