AP1G2

AP1G2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9G, 2YMT, 3ZHF, 4BCX
Identifiers
Aliases	AP1G2 , G2AD, adaptor related protein complex 1 gamma 2 subunit, adaptor related protein complex 1 subunit gamma 2
External IDs	OMIM: 603534 MGI: 1328307 HomoloGene: 49141 GeneCards: AP1G2
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 23,559,565 bp [1] End 23,568,070 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C3 Start 55,098,575 bp [2] End 55,106,593 bp [2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • Golgi-associated vesicle • membrane coat • Golgi membrane • endosome • Golgi apparatus • endosome membrane • transport vesicle • membrane • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • clathrin adaptor complex • AP-1 adaptor complex Biological process • protein transport • intracellular protein transport • GO:0022415 viral process • vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8906	11766
Ensembl	ENSG00000213983	ENSMUSG00000040701
UniProt	O75843	O88512
RefSeq (mRNA)	NM_001282474 NM_001282475 NM_003917 NM_080545 NM_001354673 NM_001354674 NM_001354675 NM_001354677 NM_001354681	NM_007455 NM_001303502
RefSeq (protein)	NP_001269403 NP_001269404 NP_003908 NP_001341602 NP_001341603 NP_001341604 NP_001341606 NP_001341610	NP_001290431 NP_031481
Location (UCSC)	Chr 14: 23.56 – 23.57 Mb	Chr 14: 55.1 – 55.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. ^{[5] [6] [7]}

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein. ^[7]

Interactions

AP1G2 has been shown to interact with NEDD4. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000213983 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040701 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem. 273 (38): 24693–700. doi: 10.1074/jbc.273.38.24693 . PMID   9733768.
6. Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2–3): 263–8. doi:10.1016/S0014-5793(98)01083-7. PMID   9762922. S2CID   83518205.
7. "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit".
8. Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway". J. Biol. Chem. United States. 283 (46): 32119–30. doi: 10.1074/jbc.M802632200 . ISSN   0021-9258. PMID   18772139.

External links

• Human AP1G2 genome location and AP1G2 gene details page in the UCSC Genome Browser .

Further reading

• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC   1083955 . PMID   11463741.
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. doi: 10.1051/medsci/2003191100 . PMID   12836198.
• Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. Bibcode:1998PNAS...9511229C. doi: 10.1073/pnas.95.19.11229 . PMC   21624 . PMID   9736718.
• Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. doi: 10.1016/S0960-9822(07)00517-9 . PMID   9811606.
• Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. doi: 10.1016/S0960-9822(07)00518-0 . PMID   9811611.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC   103959 . PMID   9882340.
• Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC   2169493 . PMID   10477754.
• Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC   115924 . PMID   11222723.
• Hartmann-Stühler C, Prange R (2001). "Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein". J. Virol. 75 (11): 5343–51. doi:10.1128/JVI.75.11.5343-5351.2001. PMC   114939 . PMID   11333915.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Janvier K, Craig H, Hitchin D, et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes". J. Biol. Chem. 278 (10): 8725–32. doi: 10.1074/jbc.M210115200 . PMID   12486136.
• Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC   140067 . PMID   12505986.
• Mattera R, Ritter B, Sidhu SS, et al. (2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi: 10.1074/jbc.M311873200 . PMID   14665628.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Coleman SH, Van Damme N, Day JR, et al. (2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes". J. Virol. 79 (4): 2066–78. doi:10.1128/JVI.79.4.2066-2078.2005. PMC   546596 . PMID   15681409.