AP3B2

AP3B2
Identifiers
Aliases	AP3B2 , NAPTB, adaptor related protein complex 3 beta 2 subunit, EIEE48, adaptor related protein complex 3 subunit beta 2, DEE48
External IDs	OMIM: 602166 MGI: 1100869 HomoloGene: 55837 GeneCards: AP3B2
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	81,143,673 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; Brodmann area 10; ; Brodmann area 9; ; cingulate gyrus; ; ganglionic eminence; ; amygdala; ; nucleus accumbens; ; hypothalamus; ; Region I of hippocampus proper; ; superior frontal gyrus;
	Top expressed in
	visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; supraoptic nucleus; ; dorsomedial hypothalamic nucleus; ; facial motor nucleus; ; hippocampus proper; ; islet of Langerhans; ; subiculum; ; habenula;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity ;
Cellular component	AP-3 adaptor complex ; membrane coat ; cytoplasmic vesicle ; clathrin-coated vesicle membrane ; membrane ; COPI-coated vesicle ; axon cytoplasm ; Golgi apparatus ; intracellular vesicle ;
Biological process	anterograde axonal transport ; protein transport ; anterograde synaptic vesicle transport ; intracellular protein transport ; vesicle-mediated transport ; post-Golgi vesicle-mediated transport ;
	Sources:Amigo / QuickGO
Orthologs
	8120
	11775
	n/a
	ENSMUSG00000062444
	Q13367
	Q9JME5
	NM_001278511 ; NM_001278512 ; NM_004644 ; NM_001348440 ; NM_001348441 Contents References ; External links ; Further reading ;
	NM_021492 ; NM_146192
	NP_001265440 ; NP_001265441 ; NP_004635 ; NP_001335369 ; NP_001335370
	NP_067467
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene.^[4]^[5]^[6]

Related Research Articles

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Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.

AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.

Charged multivesicular body protein 2b is a protein that in humans is encoded by the CHMP2B gene. It forms part of one of the endosomal sorting complexes required for transport (ESCRT) - specifically ESCRT-III - which are a series of complexes involved in cell membrane remodelling. CHMP2B forms long chains that spiral around the neck of a budding vesicle. Along with the other components of ESCRT-III, CHMP2B constricts the neck of the vesicle just before it is cleaved away from the membrane.

AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene.

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.

AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene.

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene and is involved in clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.

AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene.

Trafficking protein particle complex subunit 3 is a protein that in humans is encoded by the TRAPPC3 gene.

AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene.

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.

Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene.

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene.

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.

AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062444 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Newman LS, McKeever MO, Okano HJ, Darnell RB (Oct 1995). "Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein". Cell. 82 (5): 773–83. doi: 10.1016/0092-8674(95)90474-3 . PMID 7671305.
↑ Darnell RB, Furneaux HM, Posner JB (Jun 1991). "Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors". J Neurosci. 11 (5): 1224–30. doi:10.1523/JNEUROSCI.11-05-01224.1991. PMC 6575333 . PMID 1851215.
↑ "Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit".

External links

Human AP3B2 genome location and AP3B2 gene details page in the UCSC Genome Browser .

Dell'Angelica EC, Ohno H, Ooi CE, et al. (1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692 . PMID 9118953.
Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". Science. 280 (5362): 431–4. doi:10.1126/science.280.5362.431. PMID 9545220.
Lim DS, Kirsch DG, Canman CE, et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. doi: 10.1073/pnas.95.17.10146 . PMC 21476 . PMID 9707615.
Faundez VV, Kelly RB (2000). "The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform". Mol. Biol. Cell. 11 (8): 2591–604. doi:10.1091/mbc.11.8.2591. PMC 14942 . PMID 10930456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem. Biophys. Res. Commun. 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Chen C, Zou X, Ji C, et al. (2007). "Characterization of AP3B2_v2, a novel splice variant of human AP3B2". DNA Seq. 18 (3): 165–8. doi:10.1080/10425170600842121. PMID 17453999. S2CID 725773.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062444 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7671305-4] Newman LS, McKeever MO, Okano HJ, Darnell RB (Oct 1995). "Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein". Cell. 82 (5): 773–83. doi: 10.1016/0092-8674(95)90474-3 . PMID 7671305.

[pmid1851215-5] Darnell RB, Furneaux HM, Posner JB (Jun 1991). "Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors". J Neurosci. 11 (5): 1224–30. doi:10.1523/JNEUROSCI.11-05-01224.1991. PMC 6575333 . PMID 1851215.

[entrez-6] "Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit".

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AP3B2

Contents

Related Research Articles

References

External links

Further reading