AP3S1

AP3S1
Identifiers
Aliases	AP3S1 , CLAPS3, Sigma3A, adaptor related protein complex 3 sigma 1 subunit, adaptor related protein complex 3 subunit sigma 1
External IDs	OMIM: 601507; MGI: 1337062; HomoloGene: 4254; GeneCards: AP3S1; OMA:AP3S1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q22.3-q23.1 Start 115,841,481 bp [1] End 115,914,081 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 C Start 46,874,943 bp [2] End 46,923,893 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon hippocampus proper superior frontal gyrus anterior cingulate cortex amygdala dorsolateral prefrontal cortex nucleus accumbens ascending aorta right coronary artery tibial arteries Top expressed in ganglionic eminence thymus white adipose tissue granulocyte neural tube ileum mesencephalon ventricular zone jejunum ovary More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding transporter activity Cellular component AP-3 adaptor complex membrane coat Golgi apparatus AP-type membrane coat adaptor complex transport vesicle cytoplasmic vesicle membrane intracellular membrane-bounded organelle membrane cytoplasmic vesicle axon cytoplasm Biological process anterograde axonal transport protein transport insulin receptor signaling pathway anterograde synaptic vesicle transport intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1176 11777 Ensembl ENSG00000177879 ENSMUSG00000024480 UniProt Q92572 Q9DCR2 RefSeq (mRNA) NM_001002924 NM_001284 NM_001318090 NM_001318091 NM_001318093 NM_001318094 NM_009681 NM_001303015 RefSeq (protein) NP_001002924 NP_001275 NP_001305019 NP_001305020 NP_001305022 NP_001305023 NP_001351048 NP_001351049 NP_001351051 NP_001289944 NP_033811 Location (UCSC) Chr 5: 115.84 – 115.91 Mb Chr 18: 46.87 – 46.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000177879 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024480 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe TK, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Sep 1996). "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain". Cytogenetics and Cell Genetics. 73 (3): 214–7. doi:10.1159/000134341. PMID   8697810.
6. Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". The EMBO Journal. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC   1169692 . PMID   9118953.
7. "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit".

External links

• Human AP3S1 genome location and AP3S1 gene details page in the UCSC Genome Browser .

Further reading

• Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC   2139840 . PMID   9151686.
• VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA (November 1998). "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". The Journal of Biological Chemistry. 273 (45): 29942–9. doi: 10.1074/jbc.273.45.29942 . PMID   9792713.
• Rodionov DG, Höning S, Silye A, Kongsvik TL, von Figura K, Bakke O (December 2002). "Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3". The Journal of Biological Chemistry. 277 (49): 47436–43. doi: 10.1074/jbc.M207149200 . PMID   12370188.
• Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (September 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Developmental Cell. 5 (3): 513–21. doi: 10.1016/S1534-5807(03)00234-X . PMID   12967569.
• Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V (February 2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation". Molecular Biology of the Cell. 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC   329249 . PMID   14657250.
• Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS (October 2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes". Developmental Cell. 7 (4): 619–25. doi: 10.1016/j.devcel.2004.08.009 . PMID   15469849.