AP3S2

AP3S2
Identifiers
Aliases	AP3S2 , AP3S3, sigma3b, adaptor related protein complex 3 sigma 2 subunit, adaptor related protein complex 3 subunit sigma 2
External IDs	OMIM: 602416 MGI: 1337060 HomoloGene: 100592 GeneCards: AP3S2
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.1 Start 89,830,599 bp [1] End 89,894,638 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D2 Start 79,525,073 bp [2] End 79,570,397 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum islet of Langerhans monocyte muscle of leg gastrocnemius muscle Achilles tendon ganglionic eminence smooth muscle tissue gallbladder corpus callosum Top expressed in neural tube external carotid artery facial motor nucleus internal carotid artery ganglionic eminence retinal pigment epithelium superior frontal gyrus cerebellar cortex proximal tubule spermatocyte More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10239 11778 Ensembl ENSG00000157823 ENSMUSG00000063801 UniProt P59780 Q8BSZ2 RefSeq (mRNA) NM_005829 NM_009682 RefSeq (protein) NP_005820 NP_033812 Location (UCSC) Chr 15: 89.83 – 89.89 Mb Chr 7: 79.53 – 79.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. ^{[5] [6]}

Interactions

AP3S2 has been shown to interact with AP3B1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000157823 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063801 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC   1169692 . PMID   9118953.
6. "Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit".
7. Dell'Angelica, E C; Ooi C E; Bonifacino J S (Jun 1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. UNITED STATES. 272 (24): 15078–84. doi: 10.1074/jbc.272.24.15078 . ISSN   0021-9258. PMID   9182526.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Dell'Angelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. 272 (24): 15078–84. doi: 10.1074/jbc.272.24.15078 . PMID   9182526.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Rous BA, Reaves BJ, Ihrke G, et al. (2002). "Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes". Mol. Biol. Cell. 13 (3): 1071–82. doi:10.1091/mbc.01-08-0409. PMC   99620 . PMID   11907283.
• Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC (2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules". J. Biol. Chem. 277 (31): 28191–9. doi: 10.1074/jbc.M204011200 . PMID   12019270.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nie Z, Boehm M, Boja ES, et al. (2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Dev. Cell. 5 (3): 513–21. doi: 10.1016/S1534-5807(03)00234-X . PMID   12967569.
• Salazar G, Love R, Werner E, et al. (2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation". Mol. Biol. Cell. 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC   329249 . PMID   14657250.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lefrançois S, Janvier K, Boehm M, et al. (2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes". Dev. Cell. 7 (4): 619–25. doi: 10.1016/j.devcel.2004.08.009 . PMID   15469849.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• AP3S2 human gene location in the UCSC Genome Browser .
• AP3S2 human gene details in the UCSC Genome Browser .