APBB1IP

APBB1IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MWN, 3ZDL
Identifiers
Aliases	APBB1IP , amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein, INAG1, PREL1, RARP1, RIAM, amyloid beta precursor protein binding family B member 1 interacting protein
External IDs	OMIM: 609036; MGI: 1861354; HomoloGene: 32434; GeneCards: APBB1IP; OMA:APBB1IP - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p12.1 Start 26,438,341 bp [1] End 26,567,803 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 22,664,106 bp [2] End 22,765,665 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte inferior ganglion of vagus nerve trabecular bone spleen synovial joint lactiferous duct lymph node superficial temporal artery Top expressed in granulocyte thymus ankle joint lactiferous gland spleen mesenteric lymph nodes bone marrow blood molar pharynx More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm cell junction cell projection T cell receptor complex cytoskeleton membrane focal adhesion lamellipodium cytosol plasma membrane Biological process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell signal transduction positive regulation of cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54518 54519 Ensembl ENSG00000077420 ENSMUSG00000026786 UniProt Q7Z5R6 Q8R5A3 RefSeq (mRNA) NM_019043 NM_019456 RefSeq (protein) NP_061916 NP_062329 Location (UCSC) Chr 10: 26.44 – 26.57 Mb Chr 2: 22.66 – 22.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000077420 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026786 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: amyloid beta (A4) precursor protein-binding".
6. Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi: 10.1074/jbc.M308016200 . PMID   14530287.
7. Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl: 1721.1/83508 . PMID   15469846.

External links

• Human APBB1IP genome location and APBB1IP gene details page in the UCSC Genome Browser .

Further reading

• Lee HS, Lim CJ, Puzon-McLaughlin W, et al. (2009). "RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences". J. Biol. Chem. 284 (8): 5119–27. doi: 10.1074/jbc.M807117200 . PMC   2643525 . PMID   19098287.
• Ermekova KS, Zambrano N, Linn H, et al. (1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J. Biol. Chem. 272 (52): 32869–77. doi: 10.1074/jbc.272.52.32869 . PMID   9407065.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.
• Morgan AR, Turic D, Jehu L, et al. (2007). "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6): 762–70. doi:10.1002/ajmg.b.30509. PMID   17373700. S2CID   26081707.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins". FEBS Lett. 579 (2): 455–63. doi: 10.1016/j.febslet.2004.10.110 . PMID   15642358. S2CID   25677449.
• Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC   1380225 . PMID   16385451.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Patsoukis N, Lafuente EM, Meraner P, et al. (2009). "RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells". Sci Signal. 2 (99): ra79. doi:10.1126/scisignal.2000409. PMC   2908902 . PMID   19952372.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Linkermann A, Gelhaus C, Lettau M, et al. (2009). "Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes". Biochim. Biophys. Acta. 1794 (2): 168–76. doi:10.1016/j.bbapap.2008.10.013. PMID   19041431.
• Defilippi P, Di Stefano P, Cabodi S (2006). "p130Cas: a versatile scaffold in signaling networks". Trends Cell Biol. 16 (5): 257–63. doi:10.1016/j.tcb.2006.03.003. PMID   16581250.
• Shattil SJ (2005). "Integrins and Src: dynamic duo of adhesion signaling". Trends Cell Biol. 15 (8): 399–403. doi:10.1016/j.tcb.2005.06.005. PMID   16005629.