APBB1IP

APBB1IP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MWN, 3ZDL
Identifiers
Aliases	APBB1IP , amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein, INAG1, PREL1, RARP1, RIAM, amyloid beta precursor protein binding family B member 1 interacting protein
External IDs	OMIM: 609036 MGI: 1861354 HomoloGene: 32434 GeneCards: APBB1IP
Gene location (Human)
Chr.	Chromosome 10 (human)
End	26,567,803 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	22,765,665 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; inferior ganglion of vagus nerve; ; cancellous bone; ; spleen; ; synovial joint; ; lactiferous duct; ; lymph node; ; superficial temporal artery; ; subthalamic nucleus;
	Top expressed in
	thymus; ; Ankle joint; ; spleen; ; bone marrow; ; blood; ; molar; ; pharynx; ; sciatic nerve; ; anterior pituitary; ; extensor digitorum longus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; cell junction ; cell projection ; T cell receptor complex ; cytoskeleton ; membrane ; focal adhesion ; lamellipodium ; cytosol ; plasma membrane ;
Biological process	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ; signal transduction ; positive regulation of cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	54518
	54519
	ENSG00000077420
	ENSMUSG00000026786
	Q7Z5R6
	Q8R5A3
	NM_019043
	NM_019456
	NP_061916
	NP_062329
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.^[5]^[6]^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077420 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026786 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: amyloid beta (A4) precursor protein-binding".
↑ Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi: 10.1074/jbc.M308016200 . PMID 14530287.
↑ Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl: 1721.1/83508 . PMID 15469846.

External links

Human APBB1IP genome location and APBB1IP gene details page in the UCSC Genome Browser .

Lee HS, Lim CJ, Puzon-McLaughlin W, et al. (2009). "RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences". J. Biol. Chem. 284 (8): 5119–27. doi: 10.1074/jbc.M807117200 . PMC 2643525 . PMID 19098287.
Ermekova KS, Zambrano N, Linn H, et al. (1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J. Biol. Chem. 272 (52): 32869–77. doi: 10.1074/jbc.272.52.32869 . PMID 9407065.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Morgan AR, Turic D, Jehu L, et al. (2007). "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6): 762–70. doi:10.1002/ajmg.b.30509. PMID 17373700. S2CID 26081707.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins". FEBS Lett. 579 (2): 455–63. doi: 10.1016/j.febslet.2004.10.110 . PMID 15642358. S2CID 25677449.
Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225 . PMID 16385451.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Patsoukis N, Lafuente EM, Meraner P, et al. (2009). "RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells". Sci Signal. 2 (99): ra79. doi:10.1126/scisignal.2000409. PMC 2908902 . PMID 19952372.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Linkermann A, Gelhaus C, Lettau M, et al. (2009). "Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes". Biochim. Biophys. Acta. 1794 (2): 168–76. doi:10.1016/j.bbapap.2008.10.013. PMID 19041431.
Defilippi P, Di Stefano P, Cabodi S (2006). "p130Cas: a versatile scaffold in signaling networks". Trends Cell Biol. 16 (5): 257–63. doi:10.1016/j.tcb.2006.03.003. PMID 16581250.
Shattil SJ (2005). "Integrins and Src: dynamic duo of adhesion signaling". Trends Cell Biol. 15 (8): 399–403. doi:10.1016/j.tcb.2005.06.005. PMID 16005629.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077420 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026786 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: amyloid beta (A4) precursor protein-binding".

[pmid14530287-6] Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi: 10.1074/jbc.M308016200 . PMID 14530287.

[pmid15469846-7] Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl: 1721.1/83508 . PMID 15469846.

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APBB1IP

Contents

Related Research Articles

References

External links

Further reading