APBB3

APBB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DYQ, 2YSC
Identifiers
Aliases	APBB3 , FE65L2, SRA, amyloid beta precursor protein binding family B member 3
External IDs	OMIM: 602711; MGI: 108404; HomoloGene: 21221; GeneCards: APBB3; OMA:APBB3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 140,558,268 bp [1] End 140,564,781 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B2 Start 36,804,207 bp [2] End 36,812,419 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum left ovary right ovary right adrenal gland right testis right adrenal cortex left adrenal cortex left testis right lobe of thyroid gland pituitary gland Top expressed in neural layer of retina superior frontal gyrus primary visual cortex facial motor nucleus spermatocyte muscle of thigh dentate gyrus of hippocampal formation granule cell cerebellar cortex lumbar spinal ganglion granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function transcription factor binding amyloid-beta binding protein binding Cellular component nucleus actin cytoskeleton cytosol cytoplasm Biological process regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10307 225372 Ensembl ENSG00000113108 ENSMUSG00000117679 UniProt O95704 Q96DX9 Q8R1C9 RefSeq (mRNA) NM_133176 NM_006051 NM_133172 NM_133173 NM_133174 NM_133175 NM_146085 NM_001357512 RefSeq (protein) NP_006042 NP_573418 NP_573419 NP_573420 NP_006042.3 NP_573418.2 NP_573419.2 NP_573420.2 NP_666197 NP_001344441 Location (UCSC) Chr 5: 140.56 – 140.56 Mb Chr 18: 36.8 – 36.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113108 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000117679 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (Jan 1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J Biol Chem. 272 (52): 32869–77. doi: 10.1074/jbc.272.52.32869 . PMID   9407065.
6. "Entrez Gene: APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3".

Further reading

• Tanahashi H, Tabira T (1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID   10081969. S2CID   54307954.
• Tanahashi H, Tabira T (1999). "Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein". Biochem. Biophys. Res. Commun. 258 (2): 385–9. doi:10.1006/bbrc.1999.0639. PMID   10329396.
• Tanahashi H, Tabira T (2002). "Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains". Biochem. J. 367 (Pt 3): 687–95. doi:10.1042/BJ20020562. PMC   1222940 . PMID   12153398.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem. 278 (51): 51100–7. doi: 10.1074/jbc.M309561200 . PMID   14527950.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• APBB3 human gene location in the UCSC Genome Browser .
• APBB3 human gene details in the UCSC Genome Browser .