APIP

APIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6R
Identifiers
Aliases	APIP , APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDs	OMIM: 612491; MGI: 1926788; HomoloGene: 6277; GeneCards: APIP; OMA:APIP - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p13 Start 34,853,094 bp [1] End 34,916,379 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E2 Start 102,904,020 bp [2] End 102,922,989 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment muscle of thigh right adrenal gland corpus callosum right adrenal cortex monocyte skeletal muscle tissue left adrenal gland left adrenal cortex gastrocnemius muscle Top expressed in right ventricle interventricular septum zygote cardiac muscle tissue of left ventricle muscle of thigh secondary oocyte right kidney digastric muscle temporal muscle brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding lyase activity identical protein binding methylthioribulose 1-phosphate dehydratase activity zinc ion binding Cellular component cytoplasm cytosol Biological process methionine biosynthetic process negative regulation of apoptotic process cellular amino acid biosynthetic process regulation of ERK1 and ERK2 cascade apoptotic process pyroptosis protein homotetramerization L-methionine salvage from methylthioadenosine L-methionine salvage from S-adenosylmethionine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51074 56369 Ensembl ENSG00000149089 ENSMUSG00000010911 UniProt Q96GX9 Q9WVQ5 RefSeq (mRNA) NM_015957 NM_019735 NM_001355473 NM_001355474 RefSeq (protein) NP_057041 NP_062709 NP_001342402 NP_001342403 Location (UCSC) Chr 11: 34.85 – 34.92 Mb Chr 2: 102.9 – 102.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene. ^{[5] [6] [7]} It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity ^{[8] [9]} which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death ^[10] and cancer.

Interactions

APIP has been shown to interact with APAF1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000149089 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010911 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
6. Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi: 10.1074/jbc.M405747200 . PMID   15262985.
7. "Entrez Gene: APIP APAF1 interacting protein".
8. Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F (ed.). "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLOS ONE. 7 (12): e52877. Bibcode:2012PLoSO...752877M. doi: 10.1371/journal.pone.0052877 . PMC   3532061 . PMID   23285211.
9. Kang W, Hong SH, Lee HM, Kim NY, Lim YC, Le Le TM, Lim B, Kim HC, Kim TY, Ashida H, Yokota A, Hah SS, Chun KH, Jung YK, Yang JK (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54-61. Bibcode:2014PNAS..111E..54K. doi: 10.1073/pnas.1308768111 . PMC   3890807 . PMID   24367089.
10. Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343 –E2352. doi: 10.1073/pnas.1206701109 . PMC   3435171 . PMID   22837397.

External links

• Human APIP genome location and APIP gene details page in the UCSC Genome Browser .

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.