APPBP2

APPBP2
Identifiers
Aliases	APPBP2 , APP-BP2, HS.84084, PAT1, amyloid beta precursor protein binding protein 2
External IDs	OMIM: 605324 MGI: 1914134 HomoloGene: 31378 GeneCards: APPBP2
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q23.2 Start 60,443,158 bp [1] End 60,526,242 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 85,078,088 bp [2] End 85,125,956 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 cerebellar vermis external globus pallidus internal globus pallidus inferior olivary nucleus glomerulus middle temporal gyrus subthalamic nucleus corpus callosum Top expressed in vas deferens abdominal wall belly cord ventromedial nucleus ventral tegmental area medial ganglionic eminence medullary collecting duct dorsomedial hypothalamic nucleus lateral geniculate nucleus seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity protein binding Cellular component microtubule cytoskeleton cytoplasmic vesicle membrane membrane nucleus microtubule associated complex cytoplasm Biological process protein transport intracellular transport intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10513 66884 Ensembl ENSG00000062725 ENSMUSG00000018481 UniProt Q92624 Q9DAX9 RefSeq (mRNA) NM_001282476 NM_006380 NM_025825 RefSeq (protein) NP_001269405 NP_006371 NP_080101 Location (UCSC) Chr 17: 60.44 – 60.53 Mb Chr 11: 85.08 – 85.13 Mb PubMed search [3] [4]
Wikidata
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Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene. ^{[5] [6]}

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene. ^[6]

Interactions

APPBP2 has been shown to interact with Amyloid precursor protein. ^[5] {

References

1. GRCh38: Ensembl release 89: ENSG00000062725 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018481 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zheng P, Eastman J, Vande Pol S, Pimplikar SW (Jan 1999). "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". Proc Natl Acad Sci U S A. 95 (25): 14745–50. doi: 10.1073/pnas.95.25.14745 . PMC   24520 . PMID   9843960.
6. "Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2".

External links

• Human APPBP2 genome location and APPBP2 gene details page in the UCSC Genome Browser .

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
• Bärlund M, Monni O, Kononen J, et al. (2000). "Multiple genes at 17q23 undergo amplification and overexpression in breast cancer". Cancer Res. 60 (19): 5340–4. PMID   11034067.
• Monni O, Barlund M, Mousses S, et al. (2001). "Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5711–6. Bibcode:2001PNAS...98.5711M. doi: 10.1073/pnas.091582298 . PMC   33278 . PMID   11331760.
• Gao Y, Pimplikar SW (2002). "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14979–84. doi: 10.1073/pnas.261463298 . PMC   64969 . PMID   11742091.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Benboudjema L, Mulvey M, Gao Y, et al. (2003). "Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides". J. Virol. 77 (17): 9192–203. doi:10.1128/JVI.77.17.9192-9203.2003. PMC   187382 . PMID   12915535.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.