ARFIP1

ARFIP1
Identifiers
Aliases	ARFIP1 , HSU52521, ADP ribosylation factor interacting protein 1
External IDs	OMIM: 605928; MGI: 1277120; HomoloGene: 8692; GeneCards: ARFIP1; OMA:ARFIP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.3 Start 152,779,937 bp [1] End 152,918,463 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 84,403,400 bp [2] End 84,489,932 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte epithelium of nasopharynx visceral pleura tibia parietal pleura mucosa of sigmoid colon Achilles tendon germinal epithelium amniotic fluid endometrium Top expressed in secondary oocyte zygote primary oocyte granulocyte jejunum ileum stomach duodenum ovary placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding phosphatidylinositol-4-phosphate binding phospholipid binding Cellular component cytosol trans-Golgi network membrane Golgi membrane cytoplasm Biological process intracellular protein transport regulation of Arp2/3 complex-mediated actin nucleation regulation of protein secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27236 99889 Ensembl ENSG00000164144 ENSMUSG00000074513 UniProt P53367 G5E8V9 RefSeq (mRNA) NM_001025593 NM_001025595 NM_001287431 NM_001287432 NM_001287433 NM_014447 NM_001081093 NM_001293801 RefSeq (protein) NP_001020764 NP_001020766 NP_001274360 NP_001274361 NP_001274362 NP_055262 NP_001074562 NP_001280730 Location (UCSC) Chr 4: 152.78 – 152.92 Mb Chr 3: 84.4 – 84.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene. ^{[5] [6] [7]}

Interactions

ARFIP1 has been shown to interact with ARF3. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000164144 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074513 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kanoh H, Williger BT, Exton JH (Apr 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J Biol Chem. 272 (9): 5421–9. doi: 10.1074/jbc.272.9.5421 . PMID   9038142.
6. Williger BT, Provost JJ, Ho WT, Milstine J, Exton JH (Aug 1999). "Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D". FEBS Lett. 454 (1–2): 85–9. doi: 10.1016/S0014-5793(99)00771-1 . PMID   10413101. S2CID   40655171.
7. "Entrez Gene: ARFIP1 ADP-ribosylation factor interacting protein 1 (arfaptin 1)".

Further reading

• Tsai SC, Adamik R, Hong JX, et al. (1998). "Effects of arfaptin 1 on guanine nucleotide-dependent activation of phospholipase D and cholera toxin by ADP-ribosylation factor". J. Biol. Chem. 273 (33): 20697–701. doi: 10.1074/jbc.273.33.20697 . PMID   9694811.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC   311086 . PMID   11337467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ho WT, Exton JH, Williger BT (2003). "Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells". FEBS Lett. 537 (1–3): 91–5. doi: 10.1016/S0014-5793(03)00098-X . PMID   12606037. S2CID   44551128.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID   16396496.

External links

• Human ARFIP1 genome location and ARFIP1 gene details page in the UCSC Genome Browser .