ARHGAP26

ARHGAP26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGV
Identifiers
Aliases	ARHGAP26 , GRAF, GRAF1, OPHN1L, OPHN1L1, Rho GTPase activating protein 26
External IDs	OMIM: 605370; MGI: 1918552; HomoloGene: 36349; GeneCards: ARHGAP26; OMA:ARHGAP26 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 142,770,377 bp [1] End 143,229,011 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B3 Start 39,126,198 bp [2] End 39,509,337 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve blood epithelium of colon monocyte right uterine tube testicle granulocyte bone marrow cells Achilles tendon postcentral gyrus Top expressed in interventricular septum lobe of cerebellum cerebellar vermis zygote otolith organ utricle prefrontal cortex subiculum anterior amygdaloid area visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phospholipid binding GTPase activator activity Cellular component cytoplasm cytosol cell junction cytoskeleton focal adhesion cellular component Biological process regulation of small GTPase mediated signal transduction actin cytoskeleton organization nervous system development signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23092 71302 Ensembl ENSG00000145819 ENSMUSG00000036452 UniProt Q9UNA1 Q6ZQ82 RefSeq (mRNA) NM_001135608 NM_015071 NM_001349547 NM_175164 NM_001361073 NM_001374831 RefSeq (protein) NP_001129080 NP_055886 NP_001336476 NP_780373 NP_001348002 NP_001361760 Location (UCSC) Chr 5: 142.77 – 143.23 Mb Chr 18: 39.13 – 39.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene. ^{[5] [6] [7]}

Function

GRAF1 is a multidomain protein that is necessary for the CLIC/GEEC endocytic pathway. ^[8] By virtue of an N-terminal BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of dynamin action abrogates CLIC/GEEC endocytosis. There are several members of the GRAF family of proteins, including GRAF2, GRAF3, and oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (leukaemia and mental retardation, respectively). Recently, autoantibodies to ARHGAP26 have been implicated in autoimmune cerebellar ataxia. ^{[9] [10] [11]}

Interactions

ARHGAP26 has been shown to interact with PKN3. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000145819 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036452 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARHGAP26 Rho GTPase activating protein 26".
6. Hildebrand JD, Taylor JM, Parsons JT (June 1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Mol. Cell. Biol. 16 (6): 3169–78. doi:10.1128/MCB.16.6.3169. PMC   231310 . PMID   8649427.
7. Taylor JM, Macklem MM, Parsons JT (January 1999). "Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho" . J. Cell Sci. 112 (2): 231–42. doi:10.1242/jcs.112.2.231. PMID   9858476.
8. Lundmark R, Doherty GJ, Howes MT, Cortese K, Vallis Y, Parton RG, McMahon HT (November 2008). "The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway". Curr. Biol. 18 (22): 1802–8. doi:10.1016/j.cub.2008.10.044. PMC   2726289 . PMID   19036340.
9. Jarius S, Wandinger KP, Horn S, Heuer H, Wildemann B (2010). "A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization". J Neuroinflammation. 7 (1): 21. doi: 10.1186/1742-2094-7-21 . PMC   2848133 . PMID   20226058.
10. Jarius S, Martínez-García P, Hernandez AL, Brase JC, Borowski K, Regula JU, Meinck HM, Stöcker W, Wildemann B, Wandinger KP (Jan 2013). "Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia". J Neuroinflammation. 10 (1): 7. doi: 10.1186/1742-2094-10-7 . PMC   3549891 . PMID   23320754.
11. Doss S, Nümann A, Ziegler A, Siebert E, Borowski K, Stöcker W, Prüss H, Wildemann B, Endres M, Jarius S (15 Feb 2014). "Anti-Ca/anti-ARHGAP26 antibodies associated with cerebellar atrophy and cognitive decline". J. Neuroimmunol. 267 (1–2): 102–4. doi:10.1016/j.jneuroim.2013.10.010. PMID   24439423. S2CID   41945608.
12. Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". J. Biochem. 130 (1): 23–31. doi:10.1093/oxfordjournals.jbchem.a002958. PMID   11432776.

Further reading

• Ramakers GJ (2002). "Rho proteins, mental retardation and the cellular basis of cognition". Trends Neurosci. 25 (4): 191–9. doi:10.1016/S0166-2236(00)02118-4. PMID   11998687. S2CID   13941716.
• Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F (2000). "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9168–73. Bibcode:2000PNAS...97.9168B. doi: 10.1073/pnas.150079597 . PMC   16840 . PMID   10908648.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
• Billuart P, Bienvenu T, Ronce N, des Portes V, Vinet MC, Zemni R, Roest Crollius H, Carrié A, Fauchereau F, Cherry M, Briault S, Hamel B, Fryns JP, Beldjord C, Kahn A, Moraine C, Chelly J (1998). "Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation". Nature. 392 (6679): 923–6. Bibcode:1998Natur.392..923B. doi:10.1038/31940. PMID   9582072. S2CID   4355919.
• Taylor JM, Hildebrand JD, Mack CP, Cox ME, Parsons JT (1998). "Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase". J. Biol. Chem. 273 (14): 8063–70. doi: 10.1074/jbc.273.14.8063 . PMID   9525907.
• Pillay TS, Sasaoka T, Olefsky JM (1995). "Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase". J. Biol. Chem. 270 (3): 991–4. doi: 10.1074/jbc.270.3.991 . PMID   7836419.

External links

• ARHGAP26 Info with links in the Cell Migration Gateway
• Human ARHGAP26 genome location and ARHGAP26 gene details page in the UCSC Genome Browser .