ARHGAP27

Last updated
ARHGAP27
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARHGAP27 , CAMGAP1, PP905, SH3D20, SH3P20, Rho GTPase activating protein 27
External IDs OMIM: 610591 MGI: 1916903 HomoloGene: 45715 GeneCards: ARHGAP27
Orthologs
SpeciesHumanMouse
Entrez

201176

544817

Ensembl

ENSG00000159314
ENSG00000276836
ENSG00000276907

ENSMUSG00000034255

UniProt

Q6ZUM4
Q8N2Y9

A2AB59

RefSeq (mRNA)

NM_001159330
NM_001282290
NM_174919
NM_199282

NM_001205236
NM_133715
NM_183288

RefSeq (protein)

NP_001269219
NP_777579
NP_954976
NP_954976.1

NP_001192165
NP_598476
NP_899111

Location (UCSC) Chr 17: 45.39 – 45.43 Mb Chr 11: 103.22 – 103.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. [5]

Contents

Function

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may play a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].

Related Research Articles

<span class="mw-page-title-main">ARHGAP5</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.

<span class="mw-page-title-main">ARHGAP4</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell motility and axonal outgrowth in vitro.

<span class="mw-page-title-main">Rnd2</span> Protein-coding gene in the species Homo sapiens

Rnd2 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

<span class="mw-page-title-main">ARHGAP26</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.

<span class="mw-page-title-main">ARHGAP24</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene.

<span class="mw-page-title-main">SRGAP3</span>

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

<span class="mw-page-title-main">ARHGAP8</span>

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.

<span class="mw-page-title-main">SRGAP1</span>

SLIT-ROBO Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the SRGAP1 gene.

<span class="mw-page-title-main">ARHGAP9</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.

<span class="mw-page-title-main">ARHGAP19</span>

Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ARHGAP19 gene.

<span class="mw-page-title-main">ARHGAP31</span> Protein-coding gene in the species Homo sapiens

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.

<span class="mw-page-title-main">ARHGAP25</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as KAIA0053. ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.

<span class="mw-page-title-main">PLEKHG5</span> Protein-coding gene in the species Homo sapiens

Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.

<span class="mw-page-title-main">ARHGAP44</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 44 is a protein in humans that is encoded by the ARHGAP44 gene.

<span class="mw-page-title-main">ARHGAP11B</span>

ARHGAP11B is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ARHGAP11B in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that the gene duplication that created ARHGAP11B occurred on the human lineage after the divergence from the chimpanzee lineage but before the divergence from Neanderthals.

<span class="mw-page-title-main">ROCK2</span>

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

<span class="mw-page-title-main">Rho gtpase activating protein 21</span>

Rho GTPase activating protein 21 is a protein that in humans is encoded by the ARHGAP21 gene.

<span class="mw-page-title-main">Cdc42 effector protein 5</span> Protein-coding gene in the species Homo sapiens

CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene.

<span class="mw-page-title-main">Abr, rhogef and gtpase activating protein</span> Protein-coding gene in the species Homo sapiens

ABR, RhoGEF and GTPase activating protein is a protein that in humans is encoded by the ABR gene.

<span class="mw-page-title-main">Ras p21 protein activator 2</span>

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene.

References

  1. 1 2 3 ENSG00000276836, ENSG00000276907 GRCh38: Ensembl release 89: ENSG00000159314, ENSG00000276836, ENSG00000276907 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034255 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: Rho GTPase activating protein 27" . Retrieved 2018-05-30.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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