ARHGAP4

ARHGAP4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EPD
Identifiers
Aliases	ARHGAP4 , C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDs	OMIM: 300023; MGI: 2159577; HomoloGene: 20403; GeneCards: ARHGAP4; OMA:ARHGAP4 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 153,907,367 bp [1] End 153,934,999 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A7.3 Start 72,935,048 bp [2] End 72,965,476 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen monocyte lymph node blood right lung upper lobe of left lung appendix right hemisphere of cerebellum apex of heart Top expressed in granulocyte thymus spleen mesenteric lymph nodes blood tibiofemoral joint bone marrow subcutaneous adipose tissue otic vesicle embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity identical protein binding Cellular component cytosol Golgi apparatus growth cone microtubule cytoplasm Biological process negative regulation of fibroblast migration nervous system development positive regulation of GTPase activity negative regulation of cell migration cytoskeleton organization Rho protein signal transduction regulation of small GTPase mediated signal transduction negative regulation of axon extension signal transduction positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 393 171207 Ensembl ENSG00000089820 ENSMUSG00000031389 UniProt P98171 n/a RefSeq (mRNA) NM_001666 NM_001164741 NM_001162423 NM_001162424 NM_138630 RefSeq (protein) NP_001158213 NP_001657 n/a Location (UCSC) Chr X: 153.91 – 153.93 Mb Chr X: 72.94 – 72.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. ^{[5] [6]} It has been shown to regulate cell motility and axonal outgrowth in vitro. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000089820 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031389 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A. 93 (2): 695–9. Bibcode:1996PNAS...93..695T. doi: 10.1073/pnas.93.2.695 . PMC   40115 . PMID   8570618.
6. "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4".
7. Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth". Molecular and Cellular Neurosciences. 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC   2111057 . PMID   17804252.

External links

• Human ARHGAP4 genome location and ARHGAP4 gene details page in the UCSC Genome Browser .

Further reading

• Tribioli C, Mancini M, Plassart E, et al. (1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Hum. Mol. Genet. 3 (7): 1061–7. doi:10.1093/hmg/3.7.1061. PMID   7981673.
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi: 10.1093/dnares/2.4.167 . PMID   8590280.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID   9286695.
• Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID   10655059. S2CID   21887748.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Demura M, Takeda Y, Yoneda T, et al. (2002). "Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus". Hum. Mutat. 19 (1): 23–9. doi: 10.1002/humu.10011 . PMID   11754100. S2CID   21379792.
• Christerson LB, Gallagher E, Vanderbilt CA, et al. (2002). "p115 Rho GTPase activating protein interacts with MEKK1". J. Cell. Physiol. 192 (2): 200–8. doi:10.1002/jcp.10125. PMID   12115726. S2CID   33717402.
• Foletta VC, Brown FD, Young WS (2003). "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules". Brain Res. Mol. Brain Res. 107 (1): 65–79. doi:10.1016/S0169-328X(02)00448-5. PMID   12414125.
• Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID   12447388. S2CID   1423222.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID   12736724.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.