ARHGEF4

ARHGEF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DX1, 2PZ1, 3NMX, 3NMZ
Identifiers
Aliases	ARHGEF4 , ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDs	OMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q21.1 Start 130,836,914 bp [1] End 131,047,263 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 34,678,188 bp [2] End 34,813,309 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe nucleus accumbens prefrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex amygdala putamen caudate nucleus Brodmann area 10 Top expressed in central gray substance of midbrain pontine nuclei dorsal tegmental nucleus anterior horn of spinal cord medial vestibular nucleus superior colliculus hippocampus proper dentate gyrus facial motor nucleus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm ruffle membrane cytosol plasma membrane cell projection membrane Biological process filopodium assembly regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction lamellipodium assembly positive regulation of apoptotic process G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50649 226970 Ensembl ENSG00000136002 ENSMUSG00000037509 UniProt Q9NR80 Q7TNR9 RefSeq (mRNA) NM_015320 NM_032995 NM_001367493 NM_001375900 NM_001375901 NM_001375902 NM_001375903 NM_001375904 NM_001395416 NM_183019 NM_001368773 RefSeq (protein) NP_056135 NP_001354422 NP_001362829 NP_001362830 NP_001362831 NP_001362832 NP_001362833 NP_898840 NP_001355702 Location (UCSC) Chr 2: 130.84 – 131.05 Mb Chr 1: 34.68 – 34.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene. ^{[5] [6]}

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene. ^[6]

Interactions

ARHGEF4 has been shown to interact with APC. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136002 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037509 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thiesen S, Kübart S, Ropers HH, Nothwang HG (Jul 2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem Biophys Res Commun. 273 (1): 364–9. Bibcode:2000BBRC..273..364T. doi:10.1006/bbrc.2000.2925. PMID   10873612.
6. "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4".
7. Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID   10947987.

External links

• Human ARHGEF4 genome location and ARHGEF4 gene details page in the UCSC Genome Browser .

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, et al. (2006). "Adenomatous polyposis coli (APC) is required for normal development of skin and thymus". PLOS Genet. 2 (9): e146. doi: 10.1371/journal.pgen.0020146 . PMC   1564426 . PMID   17002498.
• Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, et al. (2005). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Dev. Cell. 7 (6): 871–83. doi: 10.1016/j.devcel.2004.10.017 . PMID   15572129.
• Kawasaki Y, Sato R, Akiyama T (2003). "Mutated APC and Asef are involved in the migration of colorectal tumour cells". Nat. Cell Biol. 5 (3): 211–5. doi:10.1038/ncb937. PMID   12598901. S2CID   22276128.
• Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID   10947987.