ARHGEF4

ARHGEF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DX1, 2PZ1, 3NMX, 3NMZ
Identifiers
Aliases	ARHGEF4 , ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDs	OMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	131,047,263 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,813,309 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; nucleus accumbens; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; putamen; ; caudate nucleus; ; Brodmann area 10;
	Top expressed in
	central gray substance of midbrain; ; pontine nuclei; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; medial vestibular nucleus; ; superior colliculus; ; hippocampus proper; ; dentate gyrus; ; facial motor nucleus; ; nucleus of stria terminalis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein domain specific binding ; guanyl-nucleotide exchange factor activity ;
Cellular component	cytoplasm ; ruffle membrane ; cytosol ; plasma membrane ; cell projection ; membrane ;
Biological process	filopodium assembly ; regulation of Rho protein signal transduction ; intracellular signal transduction ; regulation of small GTPase mediated signal transduction ; lamellipodium assembly ; positive regulation of apoptotic process ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	50649
	226970
	ENSG00000136002
	ENSMUSG00000037509
	Q9NR80
	Q7TNR9
NM_015320 ; NM_032995 ; NM_001367493 ; NM_001375900 ; NM_001375901 ;
	NM_001375902 ; NM_001375903 ; NM_001375904 ; NM_001395416 Contents Function ; Interactions ; References ; External links ; Further reading ;
	NM_183019 ; NM_001368773
NP_056135 ; NP_001354422 ; NP_001362829 ; NP_001362830 ; NP_001362831 ;
	NP_001362832 ; NP_001362833
	NP_898840 ; NP_001355702
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 08, 2024

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.^[5]^[6]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.^[6]

Interactions

ARHGEF4 has been shown to interact with APC.^[7]

Related Research Articles

Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer and desmoid tumors.

A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. This protein is also called RhoGEF1 or p115-RhoGEF.

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).

RhoG is a small monomeric GTP-binding protein, and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins and is encoded by the gene RHOG.

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

FYVE, RhoGEF and PH domain-containing protein 4 is a protein encoded in humans by the FGD4 gene.

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

Dedicator of cytokinesis protein 9 (Dock9), also known as Zizimin1, is a large protein encoded in the human by the DOCK9 gene, involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G-proteins. Dock9 activates the small G protein Cdc42.

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

Dedicator of cytokinesis protein 5 (Dock5) is a large protein encoded in the human by the DOCK5 gene, involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins. Dock5 is predicted to activate the small G protein Rac.

Dedicator of cytokinesis protein 6 (Dock6), also known as Zir1 is a large protein encoded in the human by the DOCK6 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G-proteins.

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.

Pleckstrin homology domain containing, family G member 2 (PLEKHG2) is a protein that in humans is encoded by the PLEKHG2 gene. It is sometimes written as ARHGEF42, FLJ00018.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136002 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037509 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thiesen S, Kübart S, Ropers HH, Nothwang HG (Jul 2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem Biophys Res Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
1 2 "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4".
↑ Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.

External links

Human ARHGEF4 genome location and ARHGEF4 gene details page in the UCSC Genome Browser .