Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene. [5] [6] [7]
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM] [7]
ARHGEF9 has been shown to interact with GPHN [8] and SMURF1. [9]