ARL3

ARL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FZQ, 3BH6, 3BH7, 4GOJ
Identifiers
Aliases	ARL3 , ARFL3, ADP ribosylation factor like GTPase 3, JBTS35, RP83
External IDs	OMIM: 604695 MGI: 1929699 HomoloGene: 48276 GeneCards: ARL3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,714,397 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,561,637 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; palpebral conjunctiva; ; retinal pigment epithelium; ; pons; ; tibia; ; external globus pallidus; ; orbitofrontal cortex; ; trigeminal ganglion; ; caput epididymis; ; superior vestibular nucleus;
	Top expressed in
	retinal pigment epithelium; ; motor neuron; ; medullary collecting duct; ; fossa; ; substantia nigra; ; olfactory epithelium; ; renal corpuscle; ; condyle; ; facial motor nucleus; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GDP binding ; microtubule binding ; GTP binding ; metal ion binding ; protein binding ; GTPase activity ; magnesium ion binding ; GTPase activating protein binding ;
Cellular component	cytoplasm ; centrosome ; Golgi apparatus ; cell projection ; membrane ; Golgi membrane ; spindle ; intracellular anatomical structure ; photoreceptor connecting cilium ; microtubule organizing center ; midbody ; spindle microtubule ; cytoplasmic microtubule ; extracellular exosome ; cytoskeleton ; nucleus ; cilium ; microtubule cytoskeleton ;
Biological process	cilium assembly ; kidney development ; intraciliary transport ; small GTPase mediated signal transduction ; photoreceptor cell development ; post-Golgi vesicle-mediated transport ; cell division ; protein transport ; cell cycle ; smoothened signaling pathway ; transport ; mitotic cytokinesis ; Golgi to plasma membrane transport ; protein localization to cilium ; protein localization to ciliary membrane ;
	Sources:Amigo / QuickGO
Orthologs
	403
	56350
	ENSG00000138175
	ENSMUSG00000025035
	P36405
	Q9WUL7
	NM_004311
	NM_019718 ; NM_001355233
	NP_004302
	NP_062692 ; NP_001342162
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 05, 2024

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.^[5]^[6]^[7]

Function

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.^[7]

Interactions

ARL3 has been shown to interact with Protein unc-119 homolog.^[8]^[9]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.

X-linked retinitis pigmentosa GTPase regulator is a GTPase-binding protein that in humans is encoded by the RPGR gene. The gene is located on the X-chromosome and is commonly associated with X-linked retinitis pigmentosa (XLRP). In photoreceptor cells, RPGR is localized in the connecting cilium which connects the protein-synthesizing inner segment to the photosensitive outer segment and is involved in the modulation of cargo trafficked between the two segments.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.

Uncoordinated-119 (Unc-119) is a protein that has been identified in C. elegans, humans, mice, zebrafish, rabbits, pig, calf, monkey, and protozoa. They have been classified in the GMP phosphodiesterase, delta superfamily. Unc-119 proteins are categorized into their own family but are shown to be ancestrally related to PrBP and rhoGDI. It has been given many different names: Retinal Protein 4, HRG4, POC7 Centriolar Protein Homolog A, IMD13, POC7A, and RG4.

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene. PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein that in humans is encoded by the ARL13B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138175 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025035 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA (August 1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues". J. Biol. Chem. 269 (29): 18937–42. doi: 10.1016/S0021-9258(17)32257-3 . PMID 8034651.
↑ Kim HS (1998). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 83 (3–4): 246. doi:10.1159/000015194. PMID 10072593. S2CID 35440803.
1 2 "Entrez Gene: ARL3 ADP-ribosylation factor-like 3".
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
↑ Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi: 10.1074/jbc.M102359200 . PMID 11303027.

External links

Human ARL3 genome location and ARL3 gene details page in the UCSC Genome Browser .

Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Lett. 458 (1): 55–9. doi:10.1016/S0014-5793(99)01117-5. PMID 10518933. S2CID 23460401.
Hillig RC, Hanzal-Bayer M, Linari M, Becker J, Wittinghofer A, Renault L (2000). "Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein". Structure. 8 (12): 1239–45. doi: 10.1016/S0969-2126(00)00531-1 . PMID 11188688.
Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ (2002). "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C". J. Biol. Chem. 277 (17): 14629–34. doi: 10.1074/jbc.M200128200 . PMID 11847227.
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981 . PMID 11980706.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Grayson C, Bartolini F, Chapple JP, Willison KR, Bhamidipati A, Lewis SA, Luthert PJ, Hardcastle AJ, Cowan NJ, Cheetham ME (2002). "Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3". Hum. Mol. Genet. 11 (24): 3065–74. doi: 10.1093/hmg/11.24.3065 . PMID 12417528.
Kühnel K, Veltel S, Schlichting I, Wittinghofer A (2006). "Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3". Structure. 14 (2): 367–78. doi: 10.1016/j.str.2005.11.008 . hdl: 11858/00-001M-0000-0015-8B49-9 . PMID 16472755.
Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA (2006). "Arl2 and Arl3 regulate different microtubule-dependent processes". Mol. Biol. Cell. 17 (5): 2476–87. doi:10.1091/mbc.E05-10-0929. PMC 1446103 . PMID 16525022.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138175 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025035 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8034651-5] Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA (August 1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues". J. Biol. Chem. 269 (29): 18937–42. doi: 10.1016/S0021-9258(17)32257-3 . PMID 8034651.

[pmid10072593-6] Kim HS (1998). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 83 (3–4): 246. doi:10.1159/000015194. PMID 10072593. S2CID 35440803.

[entrez-7] 1 2 "Entrez Gene: ARL3 ADP-ribosylation factor-like 3".

[pmid16169070-8] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

[pmid11303027-9] Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi: 10.1074/jbc.M102359200 . PMID 11303027.

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