ARPC5

ARPC5
Identifiers
Aliases	ARPC5 , ARC16, dJ127C7.3, p16-Arc, actin related protein 2/3 complex subunit 5
External IDs	OMIM: 604227 MGI: 1915021 HomoloGene: 4176 GeneCards: ARPC5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	183,635,783 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	152,775,597 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• actin filament binding ; • structural constituent of cytoskeleton ; • GO:0001948 protein binding ; • actin binding ;
Cellular component	• cytoplasm ; • cytosol ; • cell projection ; • focal adhesion ; • Arp2/3 protein complex ; • actin cytoskeleton ; • extracellular exosome ; • cytoskeleton ; • neuron projection ; • extracellular region ; • endosome ; • growth cone ; • secretory granule lumen ; • ficolin-1-rich granule lumen ; • lamellipodium ; • nucleus ; • site of double-strand break ;
Biological process	• movement of cell or subcellular component ; • Fc-gamma receptor signaling pathway involved in phagocytosis ; • ephrin receptor signaling pathway ; • regulation of actin filament polymerization ; • Arp2/3 complex-mediated actin nucleation ; • cell migration ; • actin cytoskeleton organization ; • actin filament network formation ; • orbitofrontal cortex development ; • lamellipodium organization ; • smooth muscle cell migration ; • maintenance of cell polarity ; • neutrophil degranulation ; • membrane organization ; • microtubule organizing center localization ;
	Sources:Amigo / QuickGO
Orthologs
	10092
	67771
	ENSG00000162704
	ENSMUSG00000008475
	O15511
	Q9CPW4
	NM_005717 ; NM_001270439
	NM_026369
	NP_001257368 ; NP_005708
	NP_080645
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 07, 2021

Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene.^[5]^[6]^[7]

Function

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined.^[7]

Interactions

ARPC5 has been shown to interact with ARPC4.^[8]^[9]

Related Research Articles

Cortactin is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.

Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene.

Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene.

Wiskott-Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.

Wiskott–Aldrich syndrome protein family member 1, also known as WASP-family verprolin homologous protein 1 (WAVE1), is a protein that in humans is encoded by the WASF1 gene.

Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.

Alpha-centractin (yeast) or ARP1 is a protein that in humans is encoded by the ACTR1A gene.

Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene.

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.

Wiskott-Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene. True to its name, it codes for a metastasis suppressor.

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.

Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene.

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.

The Actin assembly-inducing protein (ActA) is a protein encoded and used by Listeria monocytogenes to propel itself through a mammalian host cell. ActA is a bacterial surface protein comprising a membrane-spanning region. In a mammalian cell the bacterial ActA interacts with the Arp2/3 complex and actin monomers to induce actin polymerization on the bacterial surface generating an actin comet tail. The gene encoding ActA is named actA or prtB.

Arp2/3 complex is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most actin cytoskeleton-containing eukaryotic cells. Two of its subunits, the Actin-Related Proteins ARP2 and ARP3, closely resemble the structure of monomeric actin and serve as nucleation sites for new actin filaments. The complex binds to the sides of existing ("mother") filaments and initiates growth of a new ("daughter") filament at a distinctive 70 degree angle from the mother. Branched actin networks are created as a result of this nucleation of new filaments. The regulation of rearrangements of the actin cytoskeleton is important for processes like cell locomotion, phagocytosis, and intracellular motility of lipid vesicles.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162704 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008475 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 ( Pt 1) (1): 105–12. doi:10.1042/bj3280105. PMC 1218893 . PMID 9359840.
↑ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (August 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J. Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188 . PMID 9230079.
1 2 "Entrez Gene: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa".
↑ Millard TH, Behrendt B, Launay S, Fütterer K, Machesky LM (2003). "Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5". Cell Motil. Cytoskeleton. 54 (1): 81–90. doi:10.1002/cm.10087. PMID 12451597.
↑ Zhao X, Yang Z, Qian M, Zhu X (2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub". Biochem. Biophys. Res. Commun. 280 (2): 513–7. doi:10.1006/bbrc.2000.4151. PMID 11162547.

External links

ARPC5 human gene location in the UCSC Genome Browser .
ARPC5 human gene details in the UCSC Genome Browser .

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162704 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008475 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9359840-5] Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 ( Pt 1) (1): 105–12. doi:10.1042/bj3280105. PMC 1218893 . PMID 9359840.

[pmid9230079-6] Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (August 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J. Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188 . PMID 9230079.

[entrez-7] 1 2 "Entrez Gene: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa".

[pmid12451597-8] Millard TH, Behrendt B, Launay S, Fütterer K, Machesky LM (2003). "Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5". Cell Motil. Cytoskeleton. 54 (1): 81–90. doi:10.1002/cm.10087. PMID 12451597.

[pmid11162547-9] Zhao X, Yang Z, Qian M, Zhu X (2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub". Biochem. Biophys. Res. Commun. 280 (2): 513–7. doi:10.1006/bbrc.2000.4151. PMID 11162547.

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