ASAH2

ASAH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WGK
Identifiers
Aliases	ASAH2 , BCDase, HNAC1, LCDase, N-CDase, NCDase, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2, N-acylsphingosine amidohydrolase 2
External IDs	OMIM: 611202 MGI: 1859310 HomoloGene: 10310 GeneCards: ASAH2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	50,279,720 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	32,085,611 bp
RNA expression pattern
	Top expressed in
	duodenum; ; stromal cell of endometrium; ; islet of Langerhans; ; smooth muscle tissue; ; ganglionic eminence; ; thymus; ; skeletal muscle tissue; ; liver; ; fundus; ; Achilles tendon;
	Top expressed in
	intestinal villus; ; jejunum; ; lacrimal gland; ; duodenum; ; esophagus; ; parotid gland; ; motor neuron; ; medial vestibular nucleus; ; spinal cord; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity ; ceramidase activity ; calcium ion binding ; zinc ion binding ; N-acylsphingosine amidohydrolase activity ; metal ion binding ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; mitochondrion ; extracellular region ;
Biological process	lipid metabolism ; sphingolipid metabolic process ; apoptotic process ; sphingosine metabolic process ; ceramide metabolic process ; response to organic substance ; long-chain fatty acid biosynthetic process ; sphingosine biosynthetic process ; ceramide catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	56624
	54447
	ENSG00000188611
	ENSMUSG00000024887
	Q9NR71
	Q9JHE3
	NM_001143974 ; NM_019893
	NM_018830
	NP_001137446 ; NP_063946
	NP_061300
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 07, 2024

Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.^[5]^[6]

Related Research Articles

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Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P₂, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.

The ASAH1 gene encodes in humans the acid ceramidase enzyme.

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.

Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene.

<span class="mw-page-title-main">SGPL1</span> Protein-coding gene in the species Homo sapiens

Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.

Sphingosine-1-phosphate phosphatase 1 is an enzyme that in humans is encoded by the SGPP1 gene.

N-acylethanolamine-hydrolyzing acid amidase is an enzyme that in humans is encoded by the NAAA gene.

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.

Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is encoded by the ASAH2C gene.

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188611 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024887 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (Aug 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J Biol Chem. 275 (28): 21508–13. doi: 10.1074/jbc.M002522200 . PMID 10781606.
↑ "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2".

External links

Human ASAH2 genome location and ASAH2 gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : Q9NR71 (Neutral ceramidase; ASAH2) at the PDBe-KB .

Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Tani M, Okino N, Mori K, et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229–34. doi: 10.1074/jbc.275.15.11229 . PMID 10753931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Choi MS, Anderson MA, Zhang Z, et al. (2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Monick MM, Mallampalli RK, Bradford M, et al. (2004). "Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity". J. Immunol. 173 (1): 123–35. doi: 10.4049/jimmunol.173.1.123 . PMID 15210766.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hwang YH, Tani M, Nakagawa T, et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
Osawa Y, Uchinami H, Bielawski J, et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha". J. Biol. Chem. 280 (30): 27879–87. doi: 10.1074/jbc.M503002200 . PMID 15946935.
Tani M, Sano T, Ito M, Igarashi Y (2006). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets". J. Lipid Res. 46 (11): 2458–67. doi: 10.1194/jlr.M500268-JLR200 . PMID 16061940.
Galadari S, Wu BX, Mao C, et al. (2006). "Identification of a novel amidase motif in neutral ceramidase". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721 . PMID 16229686.
Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi: 10.1096/fj.05-5689com . PMID 16940153. S2CID 20973940.
Avramopoulos D, Wang R, Valle D, et al. (2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. S2CID 20156514.
Ohlsson L, Palmberg C, Duan RD, et al. (2007). "Purification and characterization of human intestinal neutral ceramidase". Biochimie. 89 (8): 950–60. doi:10.1016/j.biochi.2007.03.009. PMID 17475390.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188611 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024887 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10781606-5] El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (Aug 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J Biol Chem. 275 (28): 21508–13. doi: 10.1074/jbc.M002522200 . PMID 10781606.

[entrez-6] "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2".

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ASAH2

Contents

Related Research Articles

References

External links

Further reading