ASB13

ASB13
Identifiers
Aliases	ASB13 , ankyrin repeat and SOCS box containing 13
External IDs	OMIM: 615055 MGI: 2145525 HomoloGene: 11666 GeneCards: ASB13
Gene location (Mouse) Chr. Chromosome 13 (mouse) [1] Band 13|13 A1 Start 3,684,032 bp [1] End 3,703,822 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium right lobe of liver kidney tubule gastric mucosa kidney tibia duodenum metanephric glomerulus Brodmann area 9 prefrontal cortex Top expressed in medial vestibular nucleus pontine nuclei dorsal tegmental nucleus medial geniculate nucleus lateral geniculate nucleus inferior colliculus globus pallidus medial dorsal nucleus superior colliculus motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol Biological process protein ubiquitination intracellular signal transduction post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79754 142688 Ensembl n/a ENSMUSG00000033781 UniProt Q8WXK3 Q8VBX0 RefSeq (mRNA) NM_024701 NM_001267724 NM_178283 RefSeq (protein) NP_078977 NP_001254653 NP_840068 Location (UCSC) n/a Chr 13: 3.68 – 3.7 Mb PubMed search [2] [3]
Wikidata
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Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene. ^{[4] [5]}

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length sequences are not known. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000033781 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID   12076535.
5. "Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13".

External links

• Human ASB13 genome location and ASB13 gene details page in the UCSC Genome Browser .

Further reading

• Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi: 10.1016/j.febslet.2005.11.016 . PMID   16325183. S2CID   7196353.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.