ASTL

ASTL
Identifiers
Aliases	ASTL , SAS1B, astacin-like metallo-endopeptidase (M12 family), astacin like metalloendopeptidase, OOMD11
External IDs	OMIM: 608860 MGI: 3046414 HomoloGene: 128191 GeneCards: ASTL
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,138,502 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,199,571 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; blood; ; skin of abdomen; ; spleen; ; right lung; ; lymph node; ; cerebellar hemisphere; ; urinary bladder; ; appendix;
	Top expressed in
	secondary oocyte; ; morula; ; ovary; ; blastocyst; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity ; glutamic-type peptidase activity ; metallopeptidase activity ; hydrolase activity ; metalloendopeptidase activity ; zinc ion binding ; aspartic-type peptidase activity ; metal ion binding ;
Cellular component	plasma membrane ; transport vesicle ; cytoplasm ; membrane ; cytoplasmic vesicle ; cortical granule ;
Biological process	fertilization ; positive regulation of protein processing ; prevention of polyspermy ; proteolysis ; negative regulation of binding of sperm to zona pellucida ; single fertilization ; cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	431705
	215095
	ENSG00000188886
	ENSMUSG00000050468
	Q6HA08
	Q6HA09
	NM_001002036
	NM_001291003 ; NM_172539
	NP_001002036
	NP_001277932 ; NP_766127
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Astacin-like metalloendopeptidase is a protein that in humans is encoded by the ASTL gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188886 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050468 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "ASTL - Astacin-like metalloendopeptidase precursor - Homo sapiens (Human) - ASTL gene & protein". www.uniprot.org. Retrieved 16 June 2022.
↑ "Entrez Gene: Astacin-like metallo-endopeptidase (M12 family)".

External links

Human ASTL genome location and ASTL gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188886 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050468 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] "ASTL - Astacin-like metalloendopeptidase precursor - Homo sapiens (Human) - ASTL gene & protein". www.uniprot.org. Retrieved 16 June 2022.

[entrez-6] "Entrez Gene: Astacin-like metallo-endopeptidase (M12 family)".

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