ATF7IP

ATF7IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPQ
Identifiers
Aliases	ATF7IP , AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDs	OMIM: 613644 MGI: 1858965 HomoloGene: 10051 GeneCards: ATF7IP
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.1 Start 14,365,632 bp [1] End 14,502,935 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G1 Start 136,506,167 bp [2] End 136,610,862 bp [2]
RNA expression pattern Bgee Top expressed in cerebellum lymph node thymus inferior ganglion of vagus nerve occipital lobe tibia cecum visceral pleura More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity GO:0001948 protein binding GO:0001106 transcription corepressor activity Cellular component nucleus transcription regulator complex nucleoplasm cytosol nuclear body Biological process positive regulation of transcription, DNA-templated DNA methylation regulation of RNA polymerase II transcription preinitiation complex assembly GO:0022415 viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of protein stability protein stabilization positive regulation of DNA methylation-dependent heterochromatin assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55729	54343
Ensembl	ENSG00000171681	ENSMUSG00000030213
UniProt	Q6VMQ6	Q7TT18
RefSeq (mRNA)	NM_001286514 NM_001286515 NM_018179 NM_181352	NM_019426
RefSeq (protein)	NP_001273443 NP_001273444 NP_060649 NP_851997 NP_060649.3	NP_062299 NP_001375123 NP_001375124 NP_001375125 NP_001375126
Location (UCSC)	Chr 12: 14.37 – 14.5 Mb	Chr 6: 136.51 – 136.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene. ^{[5] [6] [7]}

Interactions

ATF7IP has been shown to interact with MBD1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000171681 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030213 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID   10976766. S2CID   1339642.
6. De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi: 10.1038/sj.onc.1203492 . PMID   10777215.
7. "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
8. Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. United States. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN   0270-7306. PMC   152570 . PMID   12665582.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC   1223464 . PMID   12659632.
• Fujita N, Watanabe S, Ichimura T, et al. (2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. PMC   152570 . PMID   12665582.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi: 10.1093/hmg/ddg162 . PMID   12812986.
• Wang H, An W, Cao R, et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell. 12 (2): 475–87. doi: 10.1016/j.molcel.2003.08.007 . PMID   14536086.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ichimura T, Watanabe S, Sakamoto Y, et al. (2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". J. Biol. Chem. 280 (14): 13928–35. doi: 10.1074/jbc.M413654200 . PMID   15691849.
• Chang LK, Chung JY, Hong YR, et al. (2005). "Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1". Nucleic Acids Res. 33 (20): 6528–39. doi:10.1093/nar/gki956. PMC   1298921 . PMID   16314315.
• Uchimura Y, Ichimura T, Uwada J, et al. (2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". J. Biol. Chem. 281 (32): 23180–90. doi: 10.1074/jbc.M602280200 . PMID   16757475.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• Human ATF7IP genome location and ATF7IP gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)